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HN2012001923A - Hidrato del hidrocloruro de agomelatina y preparacopn de este - Google Patents

Hidrato del hidrocloruro de agomelatina y preparacopn de este

Info

Publication number
HN2012001923A
HN2012001923A HN2012001923A HN2012001923A HN2012001923A HN 2012001923 A HN2012001923 A HN 2012001923A HN 2012001923 A HN2012001923 A HN 2012001923A HN 2012001923 A HN2012001923 A HN 2012001923A HN 2012001923 A HN2012001923 A HN 2012001923A
Authority
HN
Honduras
Prior art keywords
hydrochloride
hydrobromide
preparacopn
agomelatin
formula
Prior art date
Application number
HN2012001923A
Other languages
English (en)
Inventor
Hanbin Shan
Zhedong Yuan
Xueyan Zhu
Peng Zhang
Hongjuan Pan
Xiong Yu
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44599557&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HN2012001923(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of HN2012001923A publication Critical patent/HN2012001923A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/12Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PROPORCIONA UN HIDRATO DEL HIDROBROMURO DE AGOMELATINA DE FORMULA (1), EN LA QUE X ES BR, PREPARACION, USO Y COMPOSICION FARMACEUTICA DEL MISMO. DICHO HIDRATO OBTENIDO MEDIANTE EL PRESENTE METODO TIENE UNA SOLUBILIDAD SIGNIFICATIVAMENTE AUMENTADA QUE LA AGOMELATINA, Y POR ELLO ES MAS ADECUADA PARA FABRICAR FORMULACIONES FARMACEUTICAS. USANDO EL PRESENTE METODO, SE PUEDE OBTENER UNA PUREZA ELEVADA MEDIANTE DE UN PROCESO SIMPLE, SIN NINGUNA ETAPA COMPLICADA.
HN2012001923A 2010-03-17 2012-09-14 Hidrato del hidrocloruro de agomelatina y preparacopn de este HN2012001923A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2010101262639A CN102190595A (zh) 2010-03-17 2010-03-17 阿戈美拉汀溴化氢水合物及其制备方法

Publications (1)

Publication Number Publication Date
HN2012001923A true HN2012001923A (es) 2015-09-14

Family

ID=44599557

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2012001923A HN2012001923A (es) 2010-03-17 2012-09-14 Hidrato del hidrocloruro de agomelatina y preparacopn de este

Country Status (39)

Country Link
US (1) US8729132B2 (es)
EP (1) EP2547650B1 (es)
JP (1) JP5634533B2 (es)
KR (1) KR101406736B1 (es)
CN (2) CN102190595A (es)
AP (1) AP3199A (es)
AU (1) AU2011229619B2 (es)
BR (1) BR112012023173B1 (es)
CA (1) CA2792430C (es)
CL (1) CL2012002541A1 (es)
CR (1) CR20120461A (es)
CU (1) CU20120136A7 (es)
CY (1) CY1117134T1 (es)
DK (1) DK2547650T3 (es)
EA (1) EA022066B1 (es)
EC (1) ECSP12012156A (es)
ES (1) ES2572427T3 (es)
GE (1) GEP20156232B (es)
GT (1) GT201200260A (es)
HN (1) HN2012001923A (es)
HR (1) HRP20151343T1 (es)
HU (1) HUE026673T2 (es)
IL (1) IL221783A (es)
MA (1) MA34054B1 (es)
ME (1) ME02309B (es)
MX (1) MX2012010594A (es)
MY (1) MY160337A (es)
NI (1) NI201200141A (es)
NZ (1) NZ602451A (es)
PE (1) PE20130014A1 (es)
PH (1) PH12012501756A1 (es)
PL (1) PL2547650T3 (es)
PT (1) PT2547650E (es)
RS (1) RS54449B1 (es)
SG (1) SG183869A1 (es)
SI (1) SI2547650T1 (es)
TN (1) TN2012000436A1 (es)
UA (1) UA105424C2 (es)
WO (1) WO2011113363A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07115741B2 (ja) 1986-03-19 1995-12-13 株式会社石田衡器製作所 多方向仕分け装置
JPH07115739B2 (ja) 1986-03-19 1995-12-13 株式会社石田衡器製作所 多方向仕分け装置
JPH07115742B2 (ja) 1986-03-19 1995-12-13 株式会社石田衡器製作所 多方向仕分け装置
JPH07115740B2 (ja) 1986-03-19 1995-12-13 株式会社石田衡器製作所 多方向仕分け装置
FR2978916B1 (fr) 2011-08-10 2013-07-26 Servier Lab Composition pharmaceutique solide pour administration buccale d'agomelatine
CN102718675B (zh) * 2012-06-07 2015-03-25 上海右手医药科技开发有限公司 阿戈美拉汀甲磺酸复合物及其制备方法
EP2851363B1 (en) * 2012-05-14 2018-01-03 Shanghai Righthand Pharmtech. Co., Ltd. Agomelatine acid radical composite, and preparation method and application thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CZ20031397A3 (cs) * 2000-10-30 2003-11-12 Teva Pharmaceutical Industries Ltd. Nové krystalické a solvatované formy ondansetron hydrochloridu a způsoby jejich přípravy
FR2890562B1 (fr) * 2005-09-09 2012-10-12 Servier Lab Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles du sommeil chez le patient deprime
FR2899472B1 (fr) * 2006-04-07 2008-09-12 Servier Lab Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee
CN101481321B (zh) * 2009-02-27 2012-04-18 上海医药工业研究院 阿戈美拉汀卤化氢复合物及其制备方法
CN101585779B (zh) * 2009-03-10 2014-04-02 上海医药工业研究院 阿戈美拉汀的晶型vi及其制备方法和应用

Also Published As

Publication number Publication date
HUE026673T2 (en) 2016-07-28
AU2011229619B2 (en) 2014-05-22
ECSP12012156A (es) 2012-12-28
CL2012002541A1 (es) 2013-01-11
PH12012501756A1 (en) 2012-11-12
EP2547650A1 (en) 2013-01-23
PT2547650E (pt) 2015-11-30
CN102892749A (zh) 2013-01-23
DK2547650T3 (en) 2016-02-15
US8729132B2 (en) 2014-05-20
ES2572427T3 (es) 2016-05-31
RS54449B1 (sr) 2016-06-30
GT201200260A (es) 2013-11-18
AP2012006493A0 (en) 2012-10-31
IL221783A (en) 2017-11-30
MY160337A (en) 2017-02-28
GEP20156232B (en) 2015-01-26
CA2792430A1 (en) 2011-09-22
SG183869A1 (en) 2012-10-30
CN102892749B (zh) 2014-11-05
NI201200141A (es) 2012-11-09
EA022066B1 (ru) 2015-10-30
CU20120136A7 (es) 2012-12-17
WO2011113363A1 (en) 2011-09-22
TN2012000436A1 (en) 2014-01-30
KR101406736B1 (ko) 2014-06-12
EA201201293A1 (ru) 2013-04-30
KR20120128713A (ko) 2012-11-27
EP2547650A4 (en) 2013-09-18
PL2547650T3 (pl) 2016-06-30
JP5634533B2 (ja) 2014-12-03
CY1117134T1 (el) 2017-04-05
US20130012592A1 (en) 2013-01-10
MA34054B1 (fr) 2013-03-05
HK1177732A1 (en) 2013-08-30
CN102190595A (zh) 2011-09-21
MX2012010594A (es) 2012-10-03
CA2792430C (en) 2015-12-08
BR112012023173B1 (pt) 2021-08-24
JP2013522242A (ja) 2013-06-13
BR112012023173A2 (pt) 2016-05-17
UA105424C2 (uk) 2014-05-12
ME02309B (me) 2016-06-20
AP3199A (en) 2015-03-31
SI2547650T1 (sl) 2016-02-29
EP2547650B1 (en) 2015-11-04
CR20120461A (es) 2012-11-29
HRP20151343T1 (hr) 2016-01-01
NZ602451A (en) 2014-10-31
AU2011229619A1 (en) 2012-09-27
PE20130014A1 (es) 2013-01-26

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