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HN2005000474A - Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos utiles como inhibidores de cpla2 - Google Patents

Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos utiles como inhibidores de cpla2

Info

Publication number
HN2005000474A
HN2005000474A HN2005000474A HN2005000474A HN2005000474A HN 2005000474 A HN2005000474 A HN 2005000474A HN 2005000474 A HN2005000474 A HN 2005000474A HN 2005000474 A HN2005000474 A HN 2005000474A HN 2005000474 A HN2005000474 A HN 2005000474A
Authority
HN
Honduras
Prior art keywords
formula
compound
indoles
rented
synthesis
Prior art date
Application number
HN2005000474A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of HN2005000474A publication Critical patent/HN2005000474A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta invencion se refiere a un proceso para preparar Indoles sustituidos, utiles como Inhibidores de CPLA2 y compuestos intermedios con este proceso.- La presente invencion proporciona un metodo para preparar un compuesto de la formula 1 (vease formula) que comprende los pasos de hacer reaccionar compuestos de las formulas 2 y 3 (vease formulas) para producir un compuesto intermedio de la formula 4 (vease formula), donde R1,R2,R3,R4 Y R5 se definen como se describe en la invencion.- La reaccion se produce en presencia de una base, un catalizador de paladio y un catalizador de cobre, el compuesto de la formula 4 entonces se convierte en el compuesto de formula 1.- La invencion comprende ademas los compuestos de la formula 3 y 4 y los metodos para preparar los compuestos de formulas 3 y 4.
HN2005000474A 2004-08-19 2005-08-24 Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos utiles como inhibidores de cpla2 HN2005000474A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60312404P 2004-08-19 2004-08-19

Publications (1)

Publication Number Publication Date
HN2005000474A true HN2005000474A (es) 2009-04-07

Family

ID=35219553

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2005000474A HN2005000474A (es) 2004-08-19 2005-08-24 Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos utiles como inhibidores de cpla2

Country Status (24)

Country Link
US (3) US7582772B2 (es)
EP (1) EP1778629B1 (es)
JP (1) JP2008510707A (es)
KR (1) KR20070043036A (es)
CN (2) CN101006048B (es)
AR (1) AR053410A1 (es)
AT (1) ATE517084T1 (es)
AU (1) AU2005277392A1 (es)
BR (1) BRPI0514431A (es)
CA (1) CA2576008A1 (es)
CR (1) CR8936A (es)
EC (1) ECSP077244A (es)
GT (1) GT200500224A (es)
HN (1) HN2005000474A (es)
IL (1) IL181364A0 (es)
MX (1) MX2007002042A (es)
NO (1) NO20071253L (es)
PE (1) PE20060628A1 (es)
RU (1) RU2401829C2 (es)
SG (1) SG155214A1 (es)
SV (1) SV2006002200A (es)
TW (1) TW200609214A (es)
UA (1) UA85428C2 (es)
WO (1) WO2006023611A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7342119B2 (en) * 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
TW200718687A (en) * 2005-05-27 2007-05-16 Wyeth Corp Inhibitors of cytosolic phospholipase A2
WO2008055136A2 (en) * 2006-10-31 2008-05-08 Wyeth Liquid formulations of phospholipase enzyme inhibitors
JP2010508304A (ja) * 2006-10-31 2010-03-18 ワイス エルエルシー ホスホリパーゼ酵素阻害剤の半固体製剤

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02115157A (ja) * 1988-10-24 1990-04-27 Hokko Chem Ind Co Ltd スルホニルグリシン誘導体および除草剤
YU41702A (sh) * 1999-12-09 2005-07-19 Aventis Cropscience Gmbh. Nitro-sulfobenzamidi
US7101875B2 (en) 2001-12-03 2006-09-05 Wyeth Methods for treating arthritic disorders
US6635771B2 (en) 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
US6984735B2 (en) 2001-12-03 2006-01-10 Wyeth Process for making an aldehyde
CA2469138C (en) * 2001-12-03 2012-04-17 Wyeth Inhibitors of cytosolic phospholipase a2
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US6797708B2 (en) 2001-12-03 2004-09-28 Wyeth Inhibitors of cytosolic phospholipase A2
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
TW200510305A (en) * 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
US7476753B2 (en) 2003-07-29 2009-01-13 Ciba Specialty Chemicals Corporation 3-aryl-2-cyano-3-hydroxy-acrylic acid derivatives
US7582771B2 (en) 2003-09-03 2009-09-01 Wyeth Process for the synthesis of cPLA2 inhibitors
US7342119B2 (en) 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles

Also Published As

Publication number Publication date
UA85428C2 (ru) 2009-01-26
US7582772B2 (en) 2009-09-01
SV2006002200A (es) 2006-05-09
EP1778629B1 (en) 2011-07-20
NO20071253L (no) 2007-05-15
CR8936A (es) 2007-04-26
US7842837B2 (en) 2010-11-30
SG155214A1 (en) 2009-09-30
ATE517084T1 (de) 2011-08-15
JP2008510707A (ja) 2008-04-10
US20060041005A1 (en) 2006-02-23
CN101006048B (zh) 2011-07-06
MX2007002042A (es) 2007-03-29
AU2005277392A1 (en) 2006-03-02
RU2007105231A (ru) 2008-09-27
CA2576008A1 (en) 2006-03-02
CN101006048A (zh) 2007-07-25
US20110054189A1 (en) 2011-03-03
BRPI0514431A (pt) 2008-06-10
KR20070043036A (ko) 2007-04-24
US20090306428A1 (en) 2009-12-10
GT200500224A (es) 2006-03-21
ECSP077244A (es) 2007-03-29
RU2401829C2 (ru) 2010-10-20
WO2006023611A1 (en) 2006-03-02
IL181364A0 (en) 2007-07-04
TW200609214A (en) 2006-03-16
PE20060628A1 (es) 2006-08-14
AR053410A1 (es) 2007-05-09
EP1778629A1 (en) 2007-05-02
CN101830837A (zh) 2010-09-15
US8034960B2 (en) 2011-10-11

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