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HN2004000536A - Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles - Google Patents

Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles

Info

Publication number
HN2004000536A
HN2004000536A HN2004000536A HN2004000536A HN2004000536A HN 2004000536 A HN2004000536 A HN 2004000536A HN 2004000536 A HN2004000536 A HN 2004000536A HN 2004000536 A HN2004000536 A HN 2004000536A HN 2004000536 A HN2004000536 A HN 2004000536A
Authority
HN
Honduras
Prior art keywords
indoles
rental
reductive
synthesis procedure
synthesis
Prior art date
Application number
HN2004000536A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of HN2004000536A publication Critical patent/HN2004000536A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

ESTA INVENCION SSE RELACIONA CON METOLOGIA DE SINTESIS PARA LA ALQUILACION REDUCTIVA EN LA POSICION C-3 DE LOS INDOLES.
HN2004000536A 2003-12-16 2004-12-05 Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles HN2004000536A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52979703P 2003-12-16 2003-12-16

Publications (1)

Publication Number Publication Date
HN2004000536A true HN2004000536A (es) 2009-02-18

Family

ID=34700047

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2004000536A HN2004000536A (es) 2003-12-16 2004-12-05 Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles

Country Status (26)

Country Link
US (2) US7282594B2 (es)
EP (1) EP1697320B1 (es)
JP (1) JP5121232B2 (es)
KR (2) KR101194592B1 (es)
CN (1) CN1914170B (es)
AR (1) AR046895A1 (es)
AU (1) AU2004299462B2 (es)
BR (1) BRPI0417769B8 (es)
CA (1) CA2549120C (es)
CR (1) CR8446A (es)
EC (1) ECSP066648A (es)
EG (1) EG24473A (es)
GT (1) GT200400266A (es)
HN (1) HN2004000536A (es)
IL (1) IL176147A (es)
MX (1) MXPA06006669A (es)
NI (1) NI200600132A (es)
NO (1) NO20062757L (es)
PA (1) PA8620101A1 (es)
PE (1) PE20051012A1 (es)
RU (1) RU2352560C2 (es)
SG (1) SG147487A1 (es)
TW (1) TW200526576A (es)
UA (1) UA84445C2 (es)
WO (1) WO2005058820A1 (es)
ZA (1) ZA200604966B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
TW200510305A (en) 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
US7582771B2 (en) * 2003-09-03 2009-09-01 Wyeth Process for the synthesis of cPLA2 inhibitors
US7342119B2 (en) * 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
AR053410A1 (es) * 2004-08-19 2007-05-09 Wyeth Corp Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos. compuestos intermediarios
TW200718687A (en) 2005-05-27 2007-05-16 Wyeth Corp Inhibitors of cytosolic phospholipase A2
WO2008055136A2 (en) * 2006-10-31 2008-05-08 Wyeth Liquid formulations of phospholipase enzyme inhibitors
JP2010508304A (ja) * 2006-10-31 2010-03-18 ワイス エルエルシー ホスホリパーゼ酵素阻害剤の半固体製剤
CN111087340B (zh) * 2019-11-29 2021-12-07 上海应用技术大学 一种维拉佐酮中间体的制备方法
WO2024221110A1 (en) * 2023-04-27 2024-10-31 1280225 B.C. Ltd. Methods of preparing functionalized indoles

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9026427D0 (en) * 1990-12-05 1991-01-23 Ici Plc Chemical process
GB9317764D0 (en) 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
GB9609641D0 (en) * 1996-05-09 1996-07-10 Pfizer Ltd Compounds useful in therapy
US6984735B2 (en) 2001-12-03 2006-01-10 Wyeth Process for making an aldehyde
US7101875B2 (en) 2001-12-03 2006-09-05 Wyeth Methods for treating arthritic disorders
US6635771B2 (en) 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
CA2469138C (en) * 2001-12-03 2012-04-17 Wyeth Inhibitors of cytosolic phospholipase a2
US6797708B2 (en) 2001-12-03 2004-09-28 Wyeth Inhibitors of cytosolic phospholipase A2
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US20040182785A1 (en) * 2002-10-23 2004-09-23 Rigel Technology Corporation Animal plasma process by precipitation
TW200510305A (en) * 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
US7582771B2 (en) 2003-09-03 2009-09-01 Wyeth Process for the synthesis of cPLA2 inhibitors
US7342119B2 (en) * 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
AR053410A1 (es) 2004-08-19 2007-05-09 Wyeth Corp Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos. compuestos intermediarios
TW200718687A (en) 2005-05-27 2007-05-16 Wyeth Corp Inhibitors of cytosolic phospholipase A2

Also Published As

Publication number Publication date
CR8446A (es) 2006-12-07
RU2352560C2 (ru) 2009-04-20
KR20070018820A (ko) 2007-02-14
AU2004299462B2 (en) 2011-07-14
EG24473A (en) 2009-08-03
BRPI0417769B8 (pt) 2021-05-25
PE20051012A1 (es) 2006-01-13
JP5121232B2 (ja) 2013-01-16
RU2006125447A (ru) 2008-01-27
BRPI0417769B1 (pt) 2019-12-17
IL176147A0 (en) 2006-10-05
WO2005058820A1 (en) 2005-06-30
CN1914170B (zh) 2010-07-14
AR046895A1 (es) 2005-12-28
US7282594B2 (en) 2007-10-16
US7709661B2 (en) 2010-05-04
PA8620101A1 (es) 2006-03-24
US20080161581A1 (en) 2008-07-03
ZA200604966B (en) 2010-11-24
EP1697320A1 (en) 2006-09-06
KR20120082477A (ko) 2012-07-23
TW200526576A (en) 2005-08-16
NO20062757L (no) 2006-06-28
CN1914170A (zh) 2007-02-14
GT200400266A (es) 2005-08-30
CA2549120C (en) 2012-06-26
BRPI0417769A8 (pt) 2018-05-08
KR101194592B1 (ko) 2012-10-25
BRPI0417769A (pt) 2007-04-17
US20050148770A1 (en) 2005-07-07
SG147487A1 (en) 2008-11-28
AU2004299462A1 (en) 2005-06-30
IL176147A (en) 2011-12-29
NI200600132A (es) 2007-01-17
ECSP066648A (es) 2006-10-25
CA2549120A1 (en) 2005-06-30
UA84445C2 (ru) 2008-10-27
JP2007514004A (ja) 2007-05-31
MXPA06006669A (es) 2006-08-11
EP1697320B1 (en) 2013-04-10

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