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HN2001000013A - PIRIDO [2,3 - d] PIRIMIDIN - 2, 7 - DIAMINAS INHIBIDORES DE CINASAS - Google Patents

PIRIDO [2,3 - d] PIRIMIDIN - 2, 7 - DIAMINAS INHIBIDORES DE CINASAS

Info

Publication number
HN2001000013A
HN2001000013A HN2001000013A HN2001000013A HN2001000013A HN 2001000013 A HN2001000013 A HN 2001000013A HN 2001000013 A HN2001000013 A HN 2001000013A HN 2001000013 A HN2001000013 A HN 2001000013A HN 2001000013 A HN2001000013 A HN 2001000013A
Authority
HN
Honduras
Prior art keywords
pirido
pirimidin
diamines
kinase inhibiting
enzymes
Prior art date
Application number
HN2001000013A
Other languages
English (en)
Inventor
Booth Richard John
Dobrusin Ellen Myra
Josyula Vara Prasad Venkata Nagendra
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HN2001000013A publication Critical patent/HN2001000013A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A PIRIDO [2, 3-D] PIRIMIDIN 2,7- DIAMINAS QUE INHIBEN ENZIMAS DE SERINA/TREONINA CINASAS DEPENDIENTES DE CICLINA Y ENZIMAS DE TIROSSINA-CINASAS MEDIADAS POR FACTOR DE CRECIMIENTO Y COMO TALES SON UTILES PARA TRATAR ENFERMEDADES Y TRASTORNOS DE LA PROLIFERACION CELULAR.
HN2001000013A 2000-01-25 2001-01-24 PIRIDO [2,3 - d] PIRIMIDIN - 2, 7 - DIAMINAS INHIBIDORES DE CINASAS HN2001000013A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17826100P 2000-01-25 2000-01-25

Publications (1)

Publication Number Publication Date
HN2001000013A true HN2001000013A (es) 2001-06-18

Family

ID=22651853

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2001000013A HN2001000013A (es) 2000-01-25 2001-01-24 PIRIDO [2,3 - d] PIRIMIDIN - 2, 7 - DIAMINAS INHIBIDORES DE CINASAS

Country Status (34)

Country Link
EP (1) EP1254137A1 (es)
JP (1) JP4047010B2 (es)
KR (1) KR20020065939A (es)
CN (1) CN1395578A (es)
AP (1) AP2002002586A0 (es)
AR (1) AR030044A1 (es)
AU (1) AU2542501A (es)
BG (1) BG106850A (es)
BR (1) BR0107751A (es)
CA (1) CA2397961C (es)
CO (1) CO5261549A1 (es)
CR (1) CR6706A (es)
CZ (1) CZ20022475A3 (es)
DZ (1) DZ3266A1 (es)
EA (1) EA200200643A1 (es)
EE (1) EE200200405A (es)
GT (1) GT200100016A (es)
HN (1) HN2001000013A (es)
HU (1) HUP0204141A3 (es)
IL (1) IL150545A0 (es)
IS (1) IS6443A (es)
MA (1) MA26868A1 (es)
MX (1) MXPA02007221A (es)
NO (1) NO20023527L (es)
OA (1) OA12161A (es)
PA (1) PA8510701A1 (es)
PE (1) PE20011066A1 (es)
PL (1) PL356802A1 (es)
SK (1) SK10632002A3 (es)
SV (1) SV2002000294A (es)
TN (1) TNSN01014A1 (es)
WO (1) WO2001055147A1 (es)
YU (1) YU50402A (es)
ZA (1) ZA200205879B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
WO2002059083A2 (en) 2000-10-23 2002-08-01 Smithkline Beecham Corporation Novel compounds
PE20030008A1 (es) * 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
JP4603268B2 (ja) 2002-04-19 2010-12-22 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 新規化合物
RS20050363A (sr) * 2002-11-28 2007-11-15 Schering Aktiengesellschaft, Chk-,Pdk- I Akt-INHIBITORNI PIRIMIDINI, NJIHOVA PROIZVODNJA I UPOTREBA KAO FARMACEUTSKIH SREDSTAVA
US7157455B2 (en) * 2003-02-10 2007-01-02 Hoffmann-La Roche Inc. 4-Aminopyrimidine-5-one derivatives
TW200502236A (en) 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr) 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
CA2579406A1 (en) * 2004-09-21 2006-03-30 F.Hoffmann-La Roche Ag 6-(2-alkyl-phenyl) - pyrido[2,3-d] pyrimidines useful as protein kinase inhibitors
UY29439A1 (es) 2005-03-25 2006-10-02 Glaxo Group Ltd Nuevos compuestos
US20090137550A1 (en) 2005-03-25 2009-05-28 Glaxo Group Limited Novel Compounds
SG160438A1 (en) 2005-03-25 2010-04-29 Glaxo Group Ltd Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5- d]pyrimidin-2(1h)-one derivatives
PE20100737A1 (es) 2005-03-25 2010-11-27 Glaxo Group Ltd Nuevos compuestos
FR2887882B1 (fr) 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
CA2614443C (en) * 2005-07-21 2011-03-22 F. Hoffmann-La Roche Ag Pyrido [2,3-d] pyrimidine-2,4-diamine compounds as ptp1b inhibitors
BRPI0614804A2 (pt) 2005-08-09 2011-04-12 Irm Llc compostos e composições como inibidores de proteìna cinase
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (en) 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (ar) 2006-12-20 2016-09-05 Takeda Pharmaceuticals Co مثبطات كينازmapk/erk
FR2910813B1 (fr) 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
JP5697601B2 (ja) * 2008-12-01 2015-04-08 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 癌に対するオータキシン阻害剤としての２，５−ジアミノ−置換ピリド［４，３−ｄ］ピリミジン
GB201104267D0 (en) 2011-03-14 2011-04-27 Cancer Rec Tech Ltd Pyrrolopyridineamino derivatives
GB201216017D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
GB201216018D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Pharmacologically active compounds
EP2968331B1 (en) * 2013-03-14 2020-07-01 Icahn School of Medicine at Mount Sinai Pyrimidine compounds as kinase inhibitors
GB201403536D0 (en) 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
KR101671404B1 (ko) * 2014-09-02 2016-11-02 한국원자력의학원 항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) * 2016-04-11 2019-07-02 上海勋和医药科技有限公司 杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en) 2017-06-20 2017-08-02 Inst Of Cancer Research: Royal Cancer Hospital Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE190978T1 (de) * 1994-11-14 2000-04-15 Warner Lambert Co 6-aryl-pyrido(2,3-d)pyrimidine und -naphthyridine zur hemmung der durch protein-tyrosin-kinase hervorgerufenen zellvermehrung
IL115256A0 (en) * 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
US5620981A (en) * 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
KR20010043829A (ko) * 1998-05-26 2001-05-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 세포 증식 억제제로서의 비시클릭 피리미딘 및 비시클릭3,4-디히드로피리미딘

Also Published As

Publication number Publication date
CA2397961C (en) 2008-08-26
AU2542501A (en) 2001-08-07
PE20011066A1 (es) 2001-10-22
NO20023527L (no) 2002-09-10
CA2397961A1 (en) 2001-08-02
YU50402A (sh) 2005-11-28
OA12161A (en) 2006-05-08
EP1254137A1 (en) 2002-11-06
CZ20022475A3 (cs) 2003-03-12
HUP0204141A3 (en) 2005-03-29
MA26868A1 (fr) 2004-12-20
TNSN01014A1 (fr) 2005-11-10
CR6706A (es) 2005-04-04
BG106850A (bg) 2003-02-28
JP2003523357A (ja) 2003-08-05
ZA200205879B (en) 2003-09-29
SV2002000294A (es) 2002-07-16
JP4047010B2 (ja) 2008-02-13
IL150545A0 (en) 2003-02-12
DZ3266A1 (fr) 2001-08-02
BR0107751A (pt) 2002-11-12
AR030044A1 (es) 2003-08-13
IS6443A (is) 2002-06-25
EA200200643A1 (ru) 2002-12-26
HUP0204141A2 (hu) 2003-04-28
MXPA02007221A (es) 2002-11-29
CO5261549A1 (es) 2003-03-31
GT200100016A (es) 2001-10-19
CN1395578A (zh) 2003-02-05
AP2002002586A0 (en) 2002-09-30
EE200200405A (et) 2003-12-15
WO2001055147A1 (en) 2001-08-02
KR20020065939A (ko) 2002-08-14
SK10632002A3 (sk) 2003-06-03
PA8510701A1 (es) 2002-12-11
PL356802A1 (en) 2004-07-12
NO20023527D0 (no) 2002-07-24

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