CN1395578A - 吡啶并[2,3－d]嘧啶－2,7－二胺激酶抑制剂 - Google Patents

吡啶并[2,3－d]嘧啶－2,7－二胺激酶抑制剂 Download PDF

Info

Publication number: CN1395578A
Authority: CN; China
Prior art keywords: pyrido; pyrimidin; urea; piperazin; anilino
Prior art date: 2000-01-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN01804048A

Other languages

English (en)

Chinese (zh)

Inventor

R·J·布斯

E·M·杜布鲁辛

V·P·V·N·珠斯于拉

D·J·麦克纳玛拉

P·L·图古德

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-23

Publication date

2003-02-05

2001-01-23 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

2003-02-05 Publication of CN1395578A publication Critical patent/CN1395578A/zh

Status Pending legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

CN01804048A 2000-01-25 2001-01-23 吡啶并[2,3－d]嘧啶－2,7－二胺激酶抑制剂 Pending CN1395578A (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25
US60/178,261		2000-01-25

Publications (1)

Publication Number	Publication Date
CN1395578A true CN1395578A (zh)	2003-02-05

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN01804048A Pending CN1395578A (zh)	2000-01-25	2001-01-23	吡啶并[2,3－d]嘧啶－2,7－二胺激酶抑制剂

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (es)
JP (1)	JP4047010B2 (es)
KR (1)	KR20020065939A (es)
CN (1)	CN1395578A (es)
AP (1)	AP2002002586A0 (es)
AR (1)	AR030044A1 (es)
AU (1)	AU2542501A (es)
BG (1)	BG106850A (es)
BR (1)	BR0107751A (es)
CA (1)	CA2397961C (es)
CO (1)	CO5261549A1 (es)
CR (1)	CR6706A (es)
CZ (1)	CZ20022475A3 (es)
DZ (1)	DZ3266A1 (es)
EA (1)	EA200200643A1 (es)
EE (1)	EE200200405A (es)
GT (1)	GT200100016A (es)
HN (1)	HN2001000013A (es)
HU (1)	HUP0204141A3 (es)
IL (1)	IL150545A0 (es)
IS (1)	IS6443A (es)
MA (1)	MA26868A1 (es)
MX (1)	MXPA02007221A (es)
NO (1)	NO20023527L (es)
OA (1)	OA12161A (es)
PA (1)	PA8510701A1 (es)
PE (1)	PE20011066A1 (es)
PL (1)	PL356802A1 (es)
SK (1)	SK10632002A3 (es)
SV (1)	SV2002000294A (es)
TN (1)	TNSN01014A1 (es)
WO (1)	WO2001055147A1 (es)
YU (1)	YU50402A (es)
ZA (1)	ZA200205879B (es)

Families Citing this family (30)

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Publication number	Priority date	Publication date	Assignee	Title
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
WO2002059083A2 (en)	2000-10-23	2002-08-01	Smithkline Beecham Corporation	Novel compounds
PE20030008A1 (es) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4
JP4603268B2 (ja)	2002-04-19	2010-12-22	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー	新規化合物
RS20050363A (sr) *	2002-11-28	2007-11-15	Schering Aktiengesellschaft,	Chk-,Pdk- I Akt-INHIBITORNI PIRIMIDINI, NJIHOVA PROIZVODNJA I UPOTREBA KAO FARMACEUTSKIH SREDSTAVA
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en)	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr)	2004-07-15	2007-11-23	Sanofi Synthelabo	Derives de pyrido-pyrimidine, leur application en therapeutique
CA2579406A1 (en) *	2004-09-21	2006-03-30	F.Hoffmann-La Roche Ag	6-(2-alkyl-phenyl) - pyrido[2,3-d] pyrimidines useful as protein kinase inhibitors
UY29439A1 (es)	2005-03-25	2006-10-02	Glaxo Group Ltd	Nuevos compuestos
US20090137550A1 (en)	2005-03-25	2009-05-28	Glaxo Group Limited	Novel Compounds
SG160438A1 (en)	2005-03-25	2010-04-29	Glaxo Group Ltd	Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5- d]pyrimidin-2(1h)-one derivatives
PE20100737A1 (es)	2005-03-25	2010-11-27	Glaxo Group Ltd	Nuevos compuestos
FR2887882B1 (fr)	2005-07-01	2007-09-07	Sanofi Aventis Sa	Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
CA2614443C (en) *	2005-07-21	2011-03-22	F. Hoffmann-La Roche Ag	Pyrido [2,3-d] pyrimidine-2,4-diamine compounds as ptp1b inhibitors
BRPI0614804A2 (pt)	2005-08-09	2011-04-12	Irm Llc	compostos e composições como inibidores de proteìna cinase
FR2896246B1 (fr)	2006-01-13	2008-08-15	Sanofi Aventis Sa	Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (en)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (ar)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	مثبطات كينازmapk/erk
FR2910813B1 (fr)	2006-12-28	2009-02-06	Sanofi Aventis Sa	Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (en)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Improved raf inhibitors
JP5697601B2 (ja) *	2008-12-01	2015-04-08	メルクパテントゲゼルシャフトミットベシュレンクテルハフツングＭｅｒｃｋＰａｔｅｎｔＧｅｓｅｌｌｓｃｈａｆｔｍｉｔｂｅｓｃｈｒａｅｎｋｔｅｒＨａｆｔｕｎｇ	癌に対するオータキシン阻害剤としての２，５−ジアミノ−置換ピリド［４，３−ｄ］ピリミジン
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
EP2968331B1 (en) *	2013-03-14	2020-07-01	Icahn School of Medicine at Mount Sinai	Pyrimidine compounds as kinase inhibitors
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (ko) *	2014-09-02	2016-11-02	한국원자력의학원	항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE190978T1 (de) *	1994-11-14	2000-04-15	Warner Lambert Co	6-aryl-pyrido(2,3-d)pyrimidine und -naphthyridine zur hemmung der durch protein-tyrosin-kinase hervorgerufenen zellvermehrung
IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
KR20010043829A (ko) *	1998-05-26	2001-05-25	로즈 암스트롱, 크리스틴 에이. 트러트웨인	세포 증식 억제제로서의 비시클릭 피리미딘 및 비시클릭3,4-디히드로피리미딘

2001
- 2001-01-23 CN CN01804048A patent/CN1395578A/zh active Pending
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/cs unknown
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/es unknown
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/pt not_active IP Right Cessation
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/sk not_active Application Discontinuation
- 2001-01-23 YU YU50402A patent/YU50402A/sh unknown
- 2001-01-23 AR ARP010100285A patent/AR030044A1/es not_active Application Discontinuation
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/es not_active Application Discontinuation
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/ja not_active Expired - Fee Related
- 2001-01-23 EA EA200200643A patent/EA200200643A1/ru unknown
- 2001-01-23 IL IL15054501A patent/IL150545A0/xx unknown
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/es not_active Application Discontinuation
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/fr active
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/hu unknown
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/en not_active Ceased
- 2001-01-23 GT GT200100016A patent/GT200100016A/es unknown
- 2001-01-23 EP EP01900591A patent/EP1254137A1/en not_active Withdrawn
- 2001-01-23 PL PL01356802A patent/PL356802A1/xx not_active Application Discontinuation
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/ko not_active Ceased
- 2001-01-23 EE EEP200200405A patent/EE200200405A/xx unknown
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 CA CA002397961A patent/CA2397961C/en not_active Expired - Fee Related
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/es not_active Application Discontinuation
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/fr unknown
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/es unknown
- 2001-01-24 CO CO01005268A patent/CO5261549A1/es not_active Application Discontinuation
2002
- 2002-06-20 BG BG106850A patent/BG106850A/bg unknown
- 2002-06-25 IS IS6443A patent/IS6443A/is unknown
- 2002-07-17 CR CR6706A patent/CR6706A/es not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/fr unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2397961C (en)	2008-08-26
AU2542501A (en)	2001-08-07
PE20011066A1 (es)	2001-10-22
NO20023527L (no)	2002-09-10
CA2397961A1 (en)	2001-08-02
YU50402A (sh)	2005-11-28
OA12161A (en)	2006-05-08
EP1254137A1 (en)	2002-11-06
CZ20022475A3 (cs)	2003-03-12
HUP0204141A3 (en)	2005-03-29
MA26868A1 (fr)	2004-12-20
TNSN01014A1 (fr)	2005-11-10
CR6706A (es)	2005-04-04
BG106850A (bg)	2003-02-28
JP2003523357A (ja)	2003-08-05
ZA200205879B (en)	2003-09-29
SV2002000294A (es)	2002-07-16
JP4047010B2 (ja)	2008-02-13
IL150545A0 (en)	2003-02-12
DZ3266A1 (fr)	2001-08-02
BR0107751A (pt)	2002-11-12
AR030044A1 (es)	2003-08-13
IS6443A (is)	2002-06-25
EA200200643A1 (ru)	2002-12-26
HUP0204141A2 (hu)	2003-04-28
MXPA02007221A (es)	2002-11-29
CO5261549A1 (es)	2003-03-31
GT200100016A (es)	2001-10-19
AP2002002586A0 (en)	2002-09-30
EE200200405A (et)	2003-12-15
WO2001055147A1 (en)	2001-08-02
KR20020065939A (ko)	2002-08-14
HN2001000013A (es)	2001-06-18
SK10632002A3 (sk)	2003-06-03
PA8510701A1 (es)	2002-12-11
PL356802A1 (en)	2004-07-12
NO20023527D0 (no)	2002-07-24

Publication	Publication Date	Title
CN1395578A (zh)	2003-02-05	吡啶并[2,3－d]嘧啶－2,7－二胺激酶抑制剂
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CN1703414A (zh)	2005-11-30	用作细胞周期蛋白依赖性激酶抑制剂的新颖咪唑并吡啶

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2006-01-04	AD01	Patent right deemed abandoned
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