HK93387A - Benzazepin-2-ones - Google Patents

Benzazepin-2-ones Download PDF

Info

Publication number: HK93387A
Authority: HK; Hong Kong
Prior art keywords: alkyl; hydrogen; formula; cycloalkyl; lower alkyl
Prior art date: 1981-08-11

Application number

HK933/87A

Other languages

English (en)

Inventor

William Herbert Watthey Jeffrey

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-11

Filing date

1987-12-10

Publication date

1987-12-18

1987-12-10 Application filed by Novartis Ag filed Critical Novartis Ag

1987-12-18 Publication of HK93387A publication Critical patent/HK93387A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

HK933/87A 1981-08-11 1987-12-10 Benzazepin-2-ones HK93387A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29190781A	1981-08-11	1981-08-11
US31986381A	1981-11-09	1981-11-09

Publications (1)

Publication Number	Publication Date
HK93387A true HK93387A (en)	1987-12-18

Family

ID=26967047

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK933/87A HK93387A (en)	1981-08-11	1987-12-10	Benzazepin-2-ones

Country Status (22)

Country	Link
EP (1)	EP0072352B1 (xx)
KR (3)	KR890003425B1 (xx)
AR (3)	AR240806A1 (xx)
AT (1)	ATE18397T1 (xx)
AU (1)	AU561395B2 (xx)
CA (1)	CA1196636A (xx)
CY (1)	CY1403A (xx)
DD (1)	DD202546A5 (xx)
DE (1)	DE3269625D1 (xx)
DK (1)	DK157881C (xx)
ES (6)	ES8502974A1 (xx)
FI (1)	FI76074C (xx)
GB (1)	GB2103614B (xx)
GR (1)	GR77256B (xx)
HK (1)	HK93387A (xx)
HU (1)	HU189628B (xx)
IE (1)	IE53668B1 (xx)
IL (1)	IL66501A (xx)
NL (1)	NL930112I2 (xx)
NO (1)	NO161558C (xx)
NZ (1)	NZ201555A (xx)
PT (1)	PT75395B (xx)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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DE3242599A1 (de) *	1982-11-18	1984-05-24	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4473575A (en) *	1982-07-19	1984-09-25	Ciba-Geigy Corporation	3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
EP0107095B1 (en) *	1982-09-30	1987-09-09	Merck & Co. Inc.	1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4575503A (en) *	1983-02-10	1986-03-11	Ciba-Geigy Corporation	3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4564612A (en) *	1983-04-22	1986-01-14	Takeda Chemical Industries, Ltd.	Condensed, seven-membered ring compounds and their use
JPS608284A (ja) *	1983-06-29	1985-01-17	Mitsui Toatsu Chem Inc	ベンゾチアゼピン誘導体およびその製造法
US4539150A (en) *	1983-06-29	1985-09-03	Mitsui Toatsu Chemicals, Inc.	Benzothiazepine derivatives and their methods of preparation
AU570710B2 (en) *	1983-08-12	1988-03-24	Takeda Chemical Industries Ltd.	4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
US4638000A (en) *	1983-08-12	1987-01-20	Takeda Chemical Industries, Ltd.	Condensed seven-membered ring compounds, their production and use
IL72523A (en) *	1983-08-12	1988-06-30	Takeda Chemical Industries Ltd	3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
EP0166354B1 (en) *	1984-06-26	1992-08-05	Merck & Co. Inc.	Benzofused lactam compounds and pharmaceutical compositions containing them
CA1266647A (en) *	1984-06-26	1990-03-13	William H. Parsons	Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
EP0166357A3 (en) *	1984-06-26	1988-10-26	Merck & Co. Inc.	Benzofused lactams and pharmaceutical compositions containing them
US4785089A (en) *	1985-06-13	1988-11-15	Ciba-Geigy Corporation	Novel sulfonic acid esters and their preparation
DE3704661A1 (de) *	1987-02-14	1988-08-25	Hoechst Ag	Annelierte azepinon- und azocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung
EP0322779A3 (en) *	1987-12-29	1991-05-08	Yoshitomi Pharmaceutical Industries, Ltd.	Benzolactam compounds and pharmaceutical uses thereof
TW197945B (xx) *	1990-11-27	1993-01-11	Hoechst Ag
GB9100028D0 (en) *	1991-01-02	1991-02-20	Ici Plc	Compounds
GB9212308D0 (en) *	1992-06-10	1992-07-22	Ici Plc	Therapeutic compositions
US5504080A (en) *	1992-10-28	1996-04-02	Bristol-Myers Squibb Co.	Benzo-fused lactams
HUT72330A (en) *	1992-12-11	1996-04-29	Ciba Geigy Ag	Substituted benzoxazepinone derivatives, process for producing them and pharmaceutical compositions containing them
GB9310075D0 (en) *	1993-05-17	1993-06-30	Fujisawa Pharmaceutical Co	New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB9311948D0 (en) *	1993-06-10	1993-07-28	Zeneca Ltd	Substituted nitrogen heterocycles
US5801168A (en) *	1994-06-09	1998-09-01	Zeneca Limited	Substituted nitrogen heterocycles
US5597922A (en) *	1994-07-29	1997-01-28	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	Glycine receptor antagonist pharmacophore
CA2391498A1 (en) *	1999-11-18	2001-05-25	Antexpharma, Inc.	Substituted 1-benzazepines and derivatives thereof
WO2002051813A2 (en)	2000-12-27	2002-07-04	Merck Patent Gmbh	PROCESS FOR THE PREPARATION OF α-AMINOSUBSTITUTED CARBOXYLIC ACID AMIDES
EP1383741A4 (en)	2001-03-27	2006-01-04	Ranbaxy Lab Ltd	PROCESS FOR THE PREPARATION OF BENAZEPRIL
US6984645B2 (en)	2001-11-16	2006-01-10	Bristol-Myers Squibb Company	Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
JP2006500337A (ja) *	2002-07-26	2006-01-05	チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド	塩酸ベナゼプリルの結晶多形形態および非晶質形態
KR100710548B1 (ko) *	2002-12-26	2007-04-24	에스케이 주식회사	(ｓ)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1Ｈ-1-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법
US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US8080579B2 (en)	2005-10-03	2011-12-20	The Regents Of The University Of Michigan	Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2008057857A1 (en)	2006-11-01	2008-05-15	Bristol-Myers Squibb Company	MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
WO2008057862A2 (en)	2006-11-01	2008-05-15	Bristol-Myers Squibb Company	MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
CA2688161C (en)	2007-06-04	2020-10-20	Kunwar Shailubhai	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7828840B2 (en)	2007-11-15	2010-11-09	Med Institute, Inc.	Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
EP2328910B1 (en)	2008-06-04	2014-08-06	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CN102149710A (zh)	2008-06-24	2011-08-10	百时美施贵宝公司	糖皮质激素受体、AP-1和/或NF-κB 活性的环戊噻吩调节剂及其用途
EP3241839B1 (en)	2008-07-16	2019-09-04	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
HK1220611A1 (zh)	2013-03-15	2017-05-12	Bausch Health Ireland Limited	用於治疗胃肠道病症的组成物
WO2014151206A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
CN113388007A (zh)	2013-06-05	2021-09-14	博士医疗爱尔兰有限公司	鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
WO2015027021A1 (en)	2013-08-22	2015-02-26	Bristol-Myers Squibb Company	Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN113292495B (zh) *	2021-06-18	2022-09-13	迪嘉药业集团有限公司	一种 (s)-氨基化合物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3395150A (en) *	1965-02-26	1968-07-30	Squibb & Sons Inc	Benzothiazepine carboxamides and derivatives thereof
GB1305278A (xx) *	1970-03-12	1973-01-31

1982
- 1982-08-05 AT AT82810329T patent/ATE18397T1/de active
- 1982-08-05 EP EP82810329A patent/EP0072352B1/de not_active Expired
- 1982-08-05 GB GB08222564A patent/GB2103614B/en not_active Expired
- 1982-08-05 DE DE8282810329T patent/DE3269625D1/de not_active Expired
- 1982-08-05 CY CY140382A patent/CY1403A/en unknown
- 1982-08-09 PT PT75395A patent/PT75395B/pt unknown
- 1982-08-09 GR GR68996A patent/GR77256B/el unknown
- 1982-08-09 FI FI822770A patent/FI76074C/fi not_active IP Right Cessation
- 1982-08-09 ES ES514856A patent/ES8502974A1/es not_active Expired
- 1982-08-09 CA CA000409019A patent/CA1196636A/en not_active Expired
- 1982-08-09 IL IL66501A patent/IL66501A/xx not_active IP Right Cessation
- 1982-08-10 KR KR8203588A patent/KR890003425B1/ko not_active Expired
- 1982-08-10 AU AU87014/82A patent/AU561395B2/en not_active Expired
- 1982-08-10 NZ NZ201555A patent/NZ201555A/en unknown
- 1982-08-10 DD DD82242400A patent/DD202546A5/de not_active IP Right Cessation
- 1982-08-10 NO NO822722A patent/NO161558C/no not_active IP Right Cessation
- 1982-08-10 DK DK358682A patent/DK157881C/da active
- 1982-08-10 IE IE1929/82A patent/IE53668B1/en not_active IP Right Cessation
- 1982-08-10 HU HU822585A patent/HU189628B/hu unknown
- 1982-08-11 AR AR290295A patent/AR240806A1/es active
1983
- 1983-10-28 ES ES526888A patent/ES526888A0/es active Granted
- 1983-10-28 ES ES526886A patent/ES526886A0/es active Granted
- 1983-10-28 ES ES526889A patent/ES8604523A1/es not_active Expired
- 1983-10-28 ES ES526887A patent/ES8606285A1/es not_active Expired
1984
- 1984-02-28 AR AR84295865A patent/AR241222A1/es active
- 1984-02-28 AR AR295866A patent/AR240807A1/es active
- 1984-03-15 ES ES530658A patent/ES8602682A1/es not_active Expired
1987
- 1987-12-10 HK HK933/87A patent/HK93387A/xx not_active IP Right Cessation
1989
- 1989-05-13 KR KR8906486A patent/KR900001190B1/ko not_active Expired
- 1989-05-13 KR KR1019890006487A patent/KR900001191B1/ko not_active Expired
1993
- 1993-06-29 NL NL930112C patent/NL930112I2/nl unknown

Also Published As

Publication number	Publication date
DK157881B (da)	1990-02-26
IL66501A0 (en)	1982-12-31
PT75395B (en)	1985-11-15
ES530658A0 (es)	1985-12-01
GB2103614B (en)	1984-11-21
ES514856A0 (es)	1985-02-01
AR240807A2 (es)	1991-02-28
GB2103614A (en)	1983-02-23
NO161558C (no)	1989-08-30
AR241222A1 (es)	1992-02-28
ES8502974A1 (es)	1985-02-01
ES8504728A1 (es)	1985-04-16
DK358682A (da)	1983-02-12
NL930112I2 (nl)	1996-11-01
FI822770A0 (fi)	1982-08-09
NO161558B (no)	1989-05-22
IL66501A (en)	1987-10-20
ATE18397T1 (de)	1986-03-15
IE53668B1 (en)	1989-01-04
ES8601142A1 (es)	1985-11-01
HU189628B (en)	1986-07-28
DE3269625D1 (en)	1986-04-10
EP0072352B1 (de)	1986-03-05
AR240806A1 (es)	1991-02-28
DD202546A5 (de)	1983-09-21
KR890003425B1 (ko)	1989-09-20
KR840001139A (ko)	1984-03-28
ES526886A0 (es)	1985-11-01
ES8602682A1 (es)	1985-12-01
NO822722L (no)	1983-02-14
CA1196636A (en)	1985-11-12
FI76074B (fi)	1988-05-31
NZ201555A (en)	1986-06-11
ES526888A0 (es)	1985-04-16
ES8604523A1 (es)	1986-02-01
EP0072352A1 (de)	1983-02-16
ES526887A0 (es)	1986-04-16
AU8701482A (en)	1983-05-12
NL930112I1 (nl)	1993-10-18
KR900001191B1 (ko)	1990-02-28
GR77256B (xx)	1984-09-11
AR240807A1 (es)	1991-02-28
IE821929L (en)	1983-02-11
AU561395B2 (en)	1987-05-07
FI76074C (fi)	1988-09-09
ES526889A0 (es)	1986-02-01
ES8606285A1 (es)	1986-04-16
PT75395A (en)	1982-09-01
CY1403A (en)	1987-12-18
KR900001190B1 (ko)	1990-02-28
AR240806A2 (es)	1991-02-28
FI822770L (fi)	1983-02-12
DK157881C (da)	1990-07-23

Publication	Publication Date	Title
HK93387A (en)	1987-12-18	Benzazepin-2-ones
NO875188D0 (no)	1987-12-14	Karbapenemderivater, fremgangsmaate til fremstilling derav, samt preparater som inneholder dem.
AU554362B2 (en)	1986-08-21	Carboxyalkyl dipeptides
IE852108L (en)	1986-02-28	Azabicycloalkanes.
ES8504671A1 (es)	1985-05-01	Un procedimiento para obtener compuestos biciclicos derivados del indano o benzociclohexano
ES8702887A1 (es)	1987-01-16	Procedimiento para la preparacion de acetidinonas (4r)-3,4- trans-disustituidas
ES8400438A1 (es)	1983-11-01	Procedimiento para preparar derivados de (3h)-imidazo(5,1-d)-1,2,3,5-tetrazin-4-ona.
BG101402A (en)	1997-10-31	Apoliprotein-b synthesis inhibitors
MXPA02004448A (es)	2004-09-10	Derivados de imidazopiridina como inhibidores de la fosfodiesterasa vii.
MY102578A (en)	1992-07-31	Substituted 1h-imidazoles
DE3572816D1 (de)	1989-10-12	Pyridazinone inotropic agents
AU577831B2 (en)	1988-10-06	Acylamino oxo or hydroxy substituted alkylamino thiazines andthiazepines
ES8301238A1 (es)	1982-12-01	Un procedimiento para la produccion en una sola reaccion de una cefalosporina
AU574199B2 (en)	1988-06-30	Penem derivatives
AU3285000A (en)	2000-09-28	22r-hydroxycholesta-8,14-diene derivatives for the inhibition of meiosis
ATE24487T1 (de)	1987-01-15	Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
AU559935B2 (en)	1987-03-26	Imidazolyl-pyrazolyl methanone derivatives
EP0233287A4 (en)	1987-09-02	1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND CARDIOTONIC PROCESSES CONTAINING THEM.
ES8203379A1 (es)	1982-04-01	Un procedimiento para la preparacion de carbapenemas

Legal Events

Date	Code	Title	Description
2004-12-15	PE	Patent expired