AR240807A1 - Procedimiento para obtener derivados de benzazepin-2-ona y sus sales - Google Patents

Procedimiento para obtener derivados de benzazepin-2-ona y sus sales

Info

Publication number: AR240807A1
Authority: AR; Argentina
Prior art keywords: benzazepin; ona; salts; procedure; obtaining derivatives
Prior art date: 1981-08-11

Application number

AR295866A

Other languages

English (en)

Other versions

AR240807A2 (es

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-11

Filing date

1984-02-28

Publication date

1991-02-28

1984-02-28 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1991-02-28 Application granted granted Critical

1991-02-28 Publication of AR240807A2 publication Critical patent/AR240807A2/es

1991-02-28 Publication of AR240807A1 publication Critical patent/AR240807A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

AR295866A 1981-08-11 1984-02-28 Procedimiento para obtener derivados de benzazepin-2-ona y sus sales AR240807A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29190781A	1981-08-11	1981-08-11
US31986381A	1981-11-09	1981-11-09

Publications (2)

Publication Number	Publication Date
AR240807A2 AR240807A2 (es)	1991-02-28
AR240807A1 true AR240807A1 (es)	1991-02-28

Family

ID=26967047

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AR290295A AR240806A1 (es)	1981-08-11	1982-08-11	Procedimiento para la elaboracion de acidos 3-amino-(1)benzazepin- 2-ona-1-alcanoicos y sus sales.
AR84295865A AR241222A1 (es)	1981-08-11	1984-02-28	Procedimiento para elaborar nuevos acidos 3-amino- (1) benzazepin-2-alcanoicos y sus sales.
AR295866A AR240807A1 (es)	1981-08-11	1984-02-28	Procedimiento para obtener derivados de benzazepin-2-ona y sus sales

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AR290295A AR240806A1 (es)	1981-08-11	1982-08-11	Procedimiento para la elaboracion de acidos 3-amino-(1)benzazepin- 2-ona-1-alcanoicos y sus sales.
AR84295865A AR241222A1 (es)	1981-08-11	1984-02-28	Procedimiento para elaborar nuevos acidos 3-amino- (1) benzazepin-2-alcanoicos y sus sales.

Country Status (22)

Country	Link
EP (1)	EP0072352B1 (es)
KR (3)	KR890003425B1 (es)
AR (3)	AR240806A1 (es)
AT (1)	ATE18397T1 (es)
AU (1)	AU561395B2 (es)
CA (1)	CA1196636A (es)
CY (1)	CY1403A (es)
DD (1)	DD202546A5 (es)
DE (1)	DE3269625D1 (es)
DK (1)	DK157881C (es)
ES (6)	ES8502974A1 (es)
FI (1)	FI76074C (es)
GB (1)	GB2103614B (es)
GR (1)	GR77256B (es)
HK (1)	HK93387A (es)
HU (1)	HU189628B (es)
IE (1)	IE53668B1 (es)
IL (1)	IL66501A (es)
NL (1)	NL930112I2 (es)
NO (1)	NO161558C (es)
NZ (1)	NZ201555A (es)
PT (1)	PT75395B (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3242599A1 (de) *	1982-11-18	1984-05-24	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4473575A (en) *	1982-07-19	1984-09-25	Ciba-Geigy Corporation	3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
EP0107095B1 (en) *	1982-09-30	1987-09-09	Merck & Co. Inc.	1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
US4575503A (en) *	1983-02-10	1986-03-11	Ciba-Geigy Corporation	3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4564612A (en) *	1983-04-22	1986-01-14	Takeda Chemical Industries, Ltd.	Condensed, seven-membered ring compounds and their use
JPS608284A (ja) *	1983-06-29	1985-01-17	Mitsui Toatsu Chem Inc	ベンゾチアゼピン誘導体およびその製造法
US4539150A (en) *	1983-06-29	1985-09-03	Mitsui Toatsu Chemicals, Inc.	Benzothiazepine derivatives and their methods of preparation
AU570710B2 (en) *	1983-08-12	1988-03-24	Takeda Chemical Industries Ltd.	4-oxo-2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine derivatives
US4638000A (en) *	1983-08-12	1987-01-20	Takeda Chemical Industries, Ltd.	Condensed seven-membered ring compounds, their production and use
IL72523A (en) *	1983-08-12	1988-06-30	Takeda Chemical Industries Ltd	3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
EP0166354B1 (en) *	1984-06-26	1992-08-05	Merck & Co. Inc.	Benzofused lactam compounds and pharmaceutical compositions containing them
CA1266647A (en) *	1984-06-26	1990-03-13	William H. Parsons	Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists
EP0166357A3 (en) *	1984-06-26	1988-10-26	Merck & Co. Inc.	Benzofused lactams and pharmaceutical compositions containing them
US4785089A (en) *	1985-06-13	1988-11-15	Ciba-Geigy Corporation	Novel sulfonic acid esters and their preparation
DE3704661A1 (de) *	1987-02-14	1988-08-25	Hoechst Ag	Annelierte azepinon- und azocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung
EP0322779A3 (en) *	1987-12-29	1991-05-08	Yoshitomi Pharmaceutical Industries, Ltd.	Benzolactam compounds and pharmaceutical uses thereof
TW197945B (es) *	1990-11-27	1993-01-11	Hoechst Ag
GB9100028D0 (en) *	1991-01-02	1991-02-20	Ici Plc	Compounds
GB9212308D0 (en) *	1992-06-10	1992-07-22	Ici Plc	Therapeutic compositions
US5504080A (en) *	1992-10-28	1996-04-02	Bristol-Myers Squibb Co.	Benzo-fused lactams
HUT72330A (en) *	1992-12-11	1996-04-29	Ciba Geigy Ag	Substituted benzoxazepinone derivatives, process for producing them and pharmaceutical compositions containing them
GB9310075D0 (en) *	1993-05-17	1993-06-30	Fujisawa Pharmaceutical Co	New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
GB9311948D0 (en) *	1993-06-10	1993-07-28	Zeneca Ltd	Substituted nitrogen heterocycles
US5801168A (en) *	1994-06-09	1998-09-01	Zeneca Limited	Substituted nitrogen heterocycles
US5597922A (en) *	1994-07-29	1997-01-28	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	Glycine receptor antagonist pharmacophore
CA2391498A1 (en) *	1999-11-18	2001-05-25	Antexpharma, Inc.	Substituted 1-benzazepines and derivatives thereof
WO2002051813A2 (en)	2000-12-27	2002-07-04	Merck Patent Gmbh	PROCESS FOR THE PREPARATION OF α-AMINOSUBSTITUTED CARBOXYLIC ACID AMIDES
EP1383741A4 (en)	2001-03-27	2006-01-04	Ranbaxy Lab Ltd	PROCESS FOR THE PREPARATION OF BENAZEPRIL
US6984645B2 (en)	2001-11-16	2006-01-10	Bristol-Myers Squibb Company	Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
JP2006500337A (ja) *	2002-07-26	2006-01-05	チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド	塩酸ベナゼプリルの結晶多形形態および非晶質形態
KR100710548B1 (ko) *	2002-12-26	2007-04-24	에스케이 주식회사	(ｓ)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1Ｈ-1-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법
US7459474B2 (en)	2003-06-11	2008-12-02	Bristol-Myers Squibb Company	Modulators of the glucocorticoid receptor and method
US8080579B2 (en)	2005-10-03	2011-12-20	The Regents Of The University Of Michigan	Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2008057857A1 (en)	2006-11-01	2008-05-15	Bristol-Myers Squibb Company	MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
WO2008057862A2 (en)	2006-11-01	2008-05-15	Bristol-Myers Squibb Company	MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
CA2688161C (en)	2007-06-04	2020-10-20	Kunwar Shailubhai	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7828840B2 (en)	2007-11-15	2010-11-09	Med Institute, Inc.	Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
EP2328910B1 (en)	2008-06-04	2014-08-06	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CN102149710A (zh)	2008-06-24	2011-08-10	百时美施贵宝公司	糖皮质激素受体、AP-1和/或NF-κB 活性的环戊噻吩调节剂及其用途
EP3241839B1 (en)	2008-07-16	2019-09-04	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
HK1220611A1 (zh)	2013-03-15	2017-05-12	Bausch Health Ireland Limited	用於治疗胃肠道病症的组成物
WO2014151206A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
CN113388007A (zh)	2013-06-05	2021-09-14	博士医疗爱尔兰有限公司	鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
WO2015027021A1 (en)	2013-08-22	2015-02-26	Bristol-Myers Squibb Company	Imide and acylurea derivatives as modulators of the glucocorticoid receptor
CN113292495B (zh) *	2021-06-18	2022-09-13	迪嘉药业集团有限公司	一种 (s)-氨基化合物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3395150A (en) *	1965-02-26	1968-07-30	Squibb & Sons Inc	Benzothiazepine carboxamides and derivatives thereof
GB1305278A (es) *	1970-03-12	1973-01-31

1982
- 1982-08-05 AT AT82810329T patent/ATE18397T1/de active
- 1982-08-05 EP EP82810329A patent/EP0072352B1/de not_active Expired
- 1982-08-05 GB GB08222564A patent/GB2103614B/en not_active Expired
- 1982-08-05 DE DE8282810329T patent/DE3269625D1/de not_active Expired
- 1982-08-05 CY CY140382A patent/CY1403A/en unknown
- 1982-08-09 PT PT75395A patent/PT75395B/pt unknown
- 1982-08-09 GR GR68996A patent/GR77256B/el unknown
- 1982-08-09 FI FI822770A patent/FI76074C/fi not_active IP Right Cessation
- 1982-08-09 ES ES514856A patent/ES8502974A1/es not_active Expired
- 1982-08-09 CA CA000409019A patent/CA1196636A/en not_active Expired
- 1982-08-09 IL IL66501A patent/IL66501A/xx not_active IP Right Cessation
- 1982-08-10 KR KR8203588A patent/KR890003425B1/ko not_active Expired
- 1982-08-10 AU AU87014/82A patent/AU561395B2/en not_active Expired
- 1982-08-10 NZ NZ201555A patent/NZ201555A/en unknown
- 1982-08-10 DD DD82242400A patent/DD202546A5/de not_active IP Right Cessation
- 1982-08-10 NO NO822722A patent/NO161558C/no not_active IP Right Cessation
- 1982-08-10 DK DK358682A patent/DK157881C/da active
- 1982-08-10 IE IE1929/82A patent/IE53668B1/en not_active IP Right Cessation
- 1982-08-10 HU HU822585A patent/HU189628B/hu unknown
- 1982-08-11 AR AR290295A patent/AR240806A1/es active
1983
- 1983-10-28 ES ES526888A patent/ES526888A0/es active Granted
- 1983-10-28 ES ES526886A patent/ES526886A0/es active Granted
- 1983-10-28 ES ES526889A patent/ES8604523A1/es not_active Expired
- 1983-10-28 ES ES526887A patent/ES8606285A1/es not_active Expired
1984
- 1984-02-28 AR AR84295865A patent/AR241222A1/es active
- 1984-02-28 AR AR295866A patent/AR240807A1/es active
- 1984-03-15 ES ES530658A patent/ES8602682A1/es not_active Expired
1987
- 1987-12-10 HK HK933/87A patent/HK93387A/xx not_active IP Right Cessation
1989
- 1989-05-13 KR KR8906486A patent/KR900001190B1/ko not_active Expired
- 1989-05-13 KR KR1019890006487A patent/KR900001191B1/ko not_active Expired
1993
- 1993-06-29 NL NL930112C patent/NL930112I2/nl unknown

Also Published As

Publication number	Publication date
DK157881B (da)	1990-02-26
IL66501A0 (en)	1982-12-31
PT75395B (en)	1985-11-15
ES530658A0 (es)	1985-12-01
GB2103614B (en)	1984-11-21
ES514856A0 (es)	1985-02-01
AR240807A2 (es)	1991-02-28
GB2103614A (en)	1983-02-23
NO161558C (no)	1989-08-30
AR241222A1 (es)	1992-02-28
ES8502974A1 (es)	1985-02-01
ES8504728A1 (es)	1985-04-16
DK358682A (da)	1983-02-12
NL930112I2 (nl)	1996-11-01
FI822770A0 (fi)	1982-08-09
NO161558B (no)	1989-05-22
IL66501A (en)	1987-10-20
ATE18397T1 (de)	1986-03-15
IE53668B1 (en)	1989-01-04
ES8601142A1 (es)	1985-11-01
HU189628B (en)	1986-07-28
HK93387A (en)	1987-12-18
DE3269625D1 (en)	1986-04-10
EP0072352B1 (de)	1986-03-05
AR240806A1 (es)	1991-02-28
DD202546A5 (de)	1983-09-21
KR890003425B1 (ko)	1989-09-20
KR840001139A (ko)	1984-03-28
ES526886A0 (es)	1985-11-01
ES8602682A1 (es)	1985-12-01
NO822722L (no)	1983-02-14
CA1196636A (en)	1985-11-12
FI76074B (fi)	1988-05-31
NZ201555A (en)	1986-06-11
ES526888A0 (es)	1985-04-16
ES8604523A1 (es)	1986-02-01
EP0072352A1 (de)	1983-02-16
ES526887A0 (es)	1986-04-16
AU8701482A (en)	1983-05-12
NL930112I1 (nl)	1993-10-18
KR900001191B1 (ko)	1990-02-28
GR77256B (es)	1984-09-11
IE821929L (en)	1983-02-11
AU561395B2 (en)	1987-05-07
FI76074C (fi)	1988-09-09
ES526889A0 (es)	1986-02-01
ES8606285A1 (es)	1986-04-16
PT75395A (en)	1982-09-01
CY1403A (en)	1987-12-18
KR900001190B1 (ko)	1990-02-28
AR240806A2 (es)	1991-02-28
FI822770L (fi)	1983-02-12
DK157881C (da)	1990-07-23

Publication	Publication Date	Title
AR240807A1 (es)	1991-02-28	Procedimiento para obtener derivados de benzazepin-2-ona y sus sales
AR228575A1 (es)	1983-03-30	Procedimiento para obtener derivados de 7-hidroximetil o 7-carboxicamptotecina y sus sales
AR229103A1 (es)	1983-06-15	Procedimiento para la preparacion de derivados de 3-aril-5-isotiazol y sus sales
AR228444A1 (es)	1983-03-15	Procedimiento para preparar derivados de 5-bencil-tiazolidin-2,4-diona y sus sales
ES487464A0 (es)	1980-11-01	Procedimiento de preparacion de nuevos derivados aldehidos peptidil-argininos y de sus sales
AR220686A1 (es)	1980-11-28	Procedimiento para obtener derivados de 2 amino-2-desoxi-3-o-(propilcarbamoilmetil)-carbamoilmetil-glucopiranosa y sus sales
AR227731A1 (es)	1982-11-30	Procedimiento para obtener nuevos derivados de((piperidil-2)-2-etil)-4-quinoleina y sus sales
AR221080A1 (es)	1980-12-30	Procedimiento para obtener nuevos derivados de propanona y sus sales
AR230280A1 (es)	1984-03-01	Procedimiento para obtener derivados de carboestirilo y sus sales
AR227556A1 (es)	1982-11-15	Procedimiento para preparar derivados de 2-fenil-amino-2-imidazolina y sus sales
ES502643A0 (es)	1982-04-01	Procedimiento para la preparacion de compuestos de aril-fe- nil-acetileno y sus sales amonicas
AR228144A1 (es)	1983-01-31	Procedimiento para obtener derivados de 5-fenil-triazolidina-2,4-diona y sus sales
AR240044A1 (es)	1990-01-31	Procedimiento para elaborar nuevos derivados de la quinolinona y sus sales.
AR212468A1 (es)	1978-07-14	Procedimiento para la preparacion de nuevos derivados de w-alquilamidas de acidos w amino-carboxilicos y sus sales
ES530269A0 (es)	1985-12-01	Derivados de indano y sus sales
AR227272A1 (es)	1982-10-15	Procedimiento para la obtencion de compuestos de n-oxaciclil-alquil-piperidil-diaza y sus sales
AR218454A1 (es)	1980-06-13	Procedimiento para preparar derivados de 7-beta-amino o 7-beta-(2-oximino-2-furil o 2-fenilacetamido)-3-(sulfoalquil o 3-sulfoaminalquilo o 3-sulfamilalquil-tetrazol-5-il)tiometil 3-cefem-4-carboxilicos y sus sales
AR241905A1 (es)	1993-01-29	Procedimiento para obtener nuevos derivados de carboestirilo y sus sales.
AR231442A1 (es)	1984-11-30	Procedimiento para obtener novedosos derivados de piperazino-2 pirimidina y sus sales
AR228036A1 (es)	1983-01-14	Procedimiento para obtener derivados de 1-tio-alcanoilprolina y sus sales
AR224610A1 (es)	1981-12-30	Procedimiento para obtener derivados,de acidos benzacil-benzimidazol-2-carboxilicos o de 2-hidroximetilo y sus sales
ES545935A0 (es)	1986-06-01	Procedimiento para preparar nuevos derivados de dihidropiri-dina y sus sales y esteres
AR231538A1 (es)	1984-12-28	Un procedimiento para obtener derivados de 2-guanidintiazol y sus sales
AR228437A1 (es)	1983-03-15	Procedimiento para preparar compuestos de 6-fenil-2-oxo-nicotinoilamoxicilina y sus sales
ES512024A0 (es)	1983-06-01	Derivados de anilina y sus sales.