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HK1201441A1 - Process for the preparation of substituted pyrimidine derivatives - Google Patents

Process for the preparation of substituted pyrimidine derivatives Download PDF

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Publication number
HK1201441A1
HK1201441A1 HK15101911.7A HK15101911A HK1201441A1 HK 1201441 A1 HK1201441 A1 HK 1201441A1 HK 15101911 A HK15101911 A HK 15101911A HK 1201441 A1 HK1201441 A1 HK 1201441A1
Authority
HK
Hong Kong
Prior art keywords
compound
formula
group
methyl
yield
Prior art date
Application number
HK15101911.7A
Other languages
English (en)
Chinese (zh)
Inventor
Sergio Cesco-Cancian
Hongfeng Chen
Jeffrey S. Grimm
Neelakandha S. Mani
Christopher M. Mapes
David C. Palmer
Daniel J. Pippel
Kirk L. Sorgi
Tong Xiao
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41464882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1201441(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HK1201441A1 publication Critical patent/HK1201441A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15101911.7A 2008-06-30 2015-02-26 Process for the preparation of substituted pyrimidine derivatives HK1201441A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7675208P 2008-06-30 2008-06-30
US76752P 2008-06-30

Publications (1)

Publication Number Publication Date
HK1201441A1 true HK1201441A1 (en) 2015-09-04

Family

ID=41464882

Family Applications (3)

Application Number Title Priority Date Filing Date
HK15101911.7A HK1201441A1 (en) 2008-06-30 2015-02-26 Process for the preparation of substituted pyrimidine derivatives
HK16102449.5A HK1214590A1 (en) 2008-06-30 2016-03-03 Piperidine and piperazine derivatives
HK16103405.5A HK1215434A1 (en) 2008-06-30 2016-03-23 Substituted pyrimidine derivative

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK16102449.5A HK1214590A1 (en) 2008-06-30 2016-03-03 Piperidine and piperazine derivatives
HK16103405.5A HK1215434A1 (en) 2008-06-30 2016-03-23 Substituted pyrimidine derivative

Country Status (36)

Country Link
US (6) US8309720B2 (sr)
EP (5) EP2310012B1 (sr)
JP (1) JP5416768B2 (sr)
KR (1) KR101675354B1 (sr)
CN (1) CN102137672B (sr)
AR (1) AR072396A1 (sr)
AU (1) AU2009267156B2 (sr)
BR (1) BRPI0913644A2 (sr)
CA (1) CA2729733C (sr)
CO (1) CO6341560A2 (sr)
CY (1) CY1116134T1 (sr)
DK (1) DK2310012T3 (sr)
EA (1) EA019361B1 (sr)
EC (1) ECSP11010745A (sr)
ES (1) ES2538135T3 (sr)
HK (3) HK1201441A1 (sr)
HR (1) HRP20150576T1 (sr)
HU (1) HUE024949T2 (sr)
IL (4) IL210214A (sr)
JO (1) JO3043B1 (sr)
ME (1) ME02154B (sr)
MX (1) MX2011000080A (sr)
MY (1) MY150601A (sr)
NI (1) NI201000232A (sr)
NZ (1) NZ590170A (sr)
PE (1) PE20110163A1 (sr)
PL (1) PL2310012T3 (sr)
PT (1) PT2310012E (sr)
RS (1) RS53985B1 (sr)
SI (1) SI2310012T1 (sr)
SV (1) SV2011003788A (sr)
TW (3) TW201433568A (sr)
UA (1) UA106724C2 (sr)
UY (1) UY31949A (sr)
WO (1) WO2010002774A1 (sr)
ZA (1) ZA201100759B (sr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5066175B2 (ja) 2006-03-31 2012-11-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒスタミンｈ４受容体のモジュレーターとしてのベンゾイミダゾール−２−イルピリミジンおよびピラジン
NZ590170A (en) 2008-06-30 2012-04-27 Janssen Pharmaceutica Nv Process for the preparation of substituted pyrimidine derivatives
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
JP5574294B2 (ja) * 2010-11-04 2014-08-20 独立行政法人科学技術振興機構 光磁気記録媒体及び光磁気記録方法
MY180726A (en) 2013-03-06 2020-12-08 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor
SG11201608114QA (en) * 2014-03-28 2016-11-29 Kaneka Corp Method for producing tri-carbobenzoxy-arginine
WO2018093569A1 (en) 2016-11-03 2018-05-24 Bristol-Myers Squibb Company Substituted bicycle heterocyclic derivatives useful as romk channel inhibitors

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CN1285581C (zh) 2000-07-21 2006-11-22 辛根塔参与股份公司 制备4,6－二甲氧基－2－(甲基磺酰基)－1,3－嘧啶的方法
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
AU2002258400A1 (en) 2001-02-16 2002-08-28 Tularik Inc. Methods of using pyrimidine-based antiviral agents
WO2002078701A1 (en) * 2001-03-30 2002-10-10 Smithkline Beecham Corporation Use of pyrazolopyridines as therapeutic compounds
DE60210819T2 (de) * 2001-12-17 2007-04-19 Smithkline Beecham Corp. Pyrazolopyridazinderivate
TWI270542B (en) 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
ATE440827T1 (de) * 2002-12-04 2009-09-15 Ore Pharmaceuticals Inc Melanocortin-rezeptormodulatoren
AU2004235907B2 (en) 2003-05-05 2007-08-30 F. Hoffmann La-Roche Ag Fused pyrimidine derivatives with CRF activity
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NZ564222A (en) 2005-06-14 2011-10-28 Taigen Biotechnology Co Ltd Pyrimidine compounds
AU2006266529B2 (en) * 2005-07-06 2010-12-16 Cytiva Bioprocess R&D Ab Method of preparing a separation matrix
TW200800201A (en) * 2005-11-18 2008-01-01 Lilly Co Eli Pyrimidinyl benzothiophene compounds
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JP5066175B2 (ja) * 2006-03-31 2012-11-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒスタミンｈ４受容体のモジュレーターとしてのベンゾイミダゾール−２−イルピリミジンおよびピラジン
ES2349237T3 (es) * 2006-03-31 2010-12-29 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidinas como moduladores del receptor de histamina h4.
NZ590170A (en) 2008-06-30 2012-04-27 Janssen Pharmaceutica Nv Process for the preparation of substituted pyrimidine derivatives
SG192446A1 (en) * 2008-06-30 2013-08-30 Janssen Pharmaceutica Nv Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives

Also Published As

Publication number Publication date
ECSP11010745A (es) 2011-02-28
EP2310012A1 (en) 2011-04-20
MY150601A (en) 2014-01-30
TWI498326B (zh) 2015-09-01
EP2310012B1 (en) 2015-03-04
NZ590170A (en) 2012-04-27
EA201170113A1 (ru) 2011-08-30
IL235571A (en) 2016-09-29
UA106724C2 (uk) 2014-10-10
CN102137672B (zh) 2014-03-26
ES2538135T3 (es) 2015-06-17
RS53985B1 (sr) 2015-10-30
EP2924035A1 (en) 2015-09-30
US9079883B2 (en) 2015-07-14
JO3043B1 (ar) 2016-09-05
HK1156857A1 (en) 2012-06-22
KR20110023901A (ko) 2011-03-08
HUE024949T2 (en) 2016-02-29
CN102137672A (zh) 2011-07-27
IL210214A0 (en) 2011-03-31
US20140073795A1 (en) 2014-03-13
UY31949A (es) 2010-01-29
BRPI0913644A2 (pt) 2015-11-24
US20140066624A1 (en) 2014-03-06
MX2011000080A (es) 2011-03-02
AU2009267156B2 (en) 2015-05-28
HK1215434A1 (en) 2016-08-26
TW201012810A (en) 2010-04-01
AU2009267156A1 (en) 2010-01-07
TW201433568A (zh) 2014-09-01
PE20110163A1 (es) 2011-03-28
ZA201100759B (en) 2012-07-25
IL235572A (en) 2016-09-29
EP2769721A2 (en) 2014-08-27
US9006432B2 (en) 2015-04-14
TW201420583A (zh) 2014-06-01
TWI481603B (zh) 2015-04-21
US9359327B2 (en) 2016-06-07
US20130225816A1 (en) 2013-08-29
IL210214A (en) 2016-07-31
KR101675354B1 (ko) 2016-11-11
EP2769721A3 (en) 2015-04-01
EP2924025A1 (en) 2015-09-30
DK2310012T3 (da) 2015-03-30
US20100004450A1 (en) 2010-01-07
IL235570A (en) 2016-08-31
AR072396A1 (es) 2010-08-25
EP2310012A4 (en) 2012-06-20
EP2924023A1 (en) 2015-09-30
US20140121374A1 (en) 2014-05-01
ME02154B (me) 2015-10-20
PL2310012T3 (pl) 2015-08-31
US8309720B2 (en) 2012-11-13
US9079882B2 (en) 2015-07-14
CO6341560A2 (es) 2011-11-21
CA2729733C (en) 2016-10-25
HK1214590A1 (en) 2016-07-29
SI2310012T1 (sl) 2015-06-30
CA2729733A1 (en) 2010-01-07
US9079884B2 (en) 2015-07-14
NI201000232A (es) 2011-09-07
SV2011003788A (es) 2011-02-08
CY1116134T1 (el) 2017-02-08
US20130053561A1 (en) 2013-02-28
EA019361B1 (ru) 2014-03-31
PT2310012E (pt) 2015-04-02
JP5416768B2 (ja) 2014-02-12
JP2011526910A (ja) 2011-10-20
WO2010002774A1 (en) 2010-01-07
HRP20150576T1 (hr) 2015-09-11

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