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HK1049110B - 玻璃粘连蛋白受体拮抗剂 - Google Patents

玻璃粘连蛋白受体拮抗剂 Download PDF

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Publication number
HK1049110B
HK1049110B HK02109309.5A HK02109309A HK1049110B HK 1049110 B HK1049110 B HK 1049110B HK 02109309 A HK02109309 A HK 02109309A HK 1049110 B HK1049110 B HK 1049110B
Authority
HK
Hong Kong
Prior art keywords
mmole
phenyl
pyridin
ethoxy
mixture
Prior art date
Application number
HK02109309.5A
Other languages
German (de)
English (en)
French (fr)
Other versions
HK1049110A1 (zh
Inventor
J. Manley Peter
H. Miller William
N. Uzinskas Irene
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of HK1049110A1 publication Critical patent/HK1049110A1/zh
Publication of HK1049110B publication Critical patent/HK1049110B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • External Artificial Organs (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK02109309.5A 1999-09-07 2000-09-07 玻璃粘连蛋白受体拮抗剂 HK1049110B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15278099P 1999-09-07 1999-09-07
US152780P 1999-09-07
PCT/US2000/024514 WO2001017959A2 (en) 1999-09-07 2000-09-07 Vitronectin receptor antagonists

Publications (2)

Publication Number Publication Date
HK1049110A1 HK1049110A1 (zh) 2003-05-02
HK1049110B true HK1049110B (zh) 2005-07-22

Family

ID=22544416

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02109309.5A HK1049110B (zh) 1999-09-07 2000-09-07 玻璃粘连蛋白受体拮抗剂

Country Status (29)

Country Link
EP (1) EP1218005B1 (zh)
JP (1) JP4685307B2 (zh)
KR (1) KR100711170B1 (zh)
CN (1) CN1236767C (zh)
AR (1) AR025589A1 (zh)
AT (1) ATE284870T1 (zh)
AU (1) AU768918B2 (zh)
BR (1) BR0013749A (zh)
CA (1) CA2384671A1 (zh)
CO (1) CO5200845A1 (zh)
CZ (1) CZ2002822A3 (zh)
DE (1) DE60016769T2 (zh)
EG (1) EG24179A (zh)
ES (1) ES2234658T3 (zh)
GC (1) GC0000203A (zh)
HK (1) HK1049110B (zh)
HU (1) HUP0202710A3 (zh)
IL (2) IL148325A0 (zh)
MX (1) MXPA02002455A (zh)
NO (1) NO322109B1 (zh)
NZ (1) NZ517296A (zh)
PE (1) PE20010582A1 (zh)
PL (1) PL200404B1 (zh)
PT (1) PT1218005E (zh)
TR (1) TR200200614T2 (zh)
TW (1) TWI255813B (zh)
UY (1) UY26329A1 (zh)
WO (1) WO2001017959A2 (zh)
ZA (1) ZA200201780B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6531494B1 (en) 2001-08-29 2003-03-11 Pharmacia Corporation Gem-substituted αvβ3 antagonists
US6982263B2 (en) 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases
GB0315509D0 (en) 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
RU2367661C2 (ru) * 2004-03-05 2009-09-20 Тайсо Фармасьютикал Ко., Лтд. Производные тиазола
DK2593452T3 (en) 2010-07-14 2017-04-24 Novartis Ag Heterocyclic compounds as IP receptor agonists
TW201335160A (zh) 2012-01-13 2013-09-01 Novartis Ag Ｉｐ受體激動劑之雜環化合物
JP2016507582A (ja) 2013-02-13 2016-03-10 ノバルティス アーゲー Ｉｐ受容体アゴニスト複素環式化合物
CN108675954A (zh) * 2018-04-03 2018-10-19 爱斯特（成都）生物制药股份有限公司 2-氨基-3-羟甲基吡啶的一种制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325264A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−芳香環置換−３−フェニルプロピオン酸またはアクリル酸誘導体
JPH08325263A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−アミノ−３−フェニルプロピオン酸誘導体
BR9612378A (pt) * 1995-12-29 1999-07-13 Smithkline Beecham Corp Antagonistas receptores de vitronectina
WO1999011255A1 (en) * 1997-08-28 1999-03-11 Ono Pharmaceutical Co., Ltd. Peroxisome proliferator-activated receptor controllers
DZ2609A1 (fr) * 1997-09-19 2003-03-01 Smithkline Beecham Corp Composés nouveaux antagonistes des récepteurs de vitronectine et compositions pharmaceutiques les contenant.
CO5080762A1 (es) * 1998-03-10 2001-09-25 Smithkline Beechman Corp Antagonistas de receptor de vitronectina
CA2338878A1 (en) * 1998-08-13 2000-02-24 Merck & Co., Inc. Integrin receptor antagonists

Also Published As

Publication number Publication date
MXPA02002455A (es) 2002-07-02
EP1218005A4 (en) 2002-10-09
HUP0202710A3 (en) 2003-06-30
EG24179A (en) 2008-09-28
WO2001017959A2 (en) 2001-03-15
CZ2002822A3 (cs) 2002-07-17
AU768918B2 (en) 2004-01-08
WO2001017959A3 (en) 2001-05-10
NO20021113L (no) 2002-05-03
DE60016769T2 (de) 2005-11-24
CN1236767C (zh) 2006-01-18
NO322109B1 (no) 2006-08-14
CO5200845A1 (es) 2002-09-27
NO20021113D0 (no) 2002-03-06
IL148325A (en) 2007-06-03
ZA200201780B (en) 2003-05-28
HK1049110A1 (zh) 2003-05-02
PL200404B1 (pl) 2009-01-30
NZ517296A (en) 2003-11-28
EP1218005A2 (en) 2002-07-03
PE20010582A1 (es) 2001-06-23
JP2003508516A (ja) 2003-03-04
BR0013749A (pt) 2003-06-10
CA2384671A1 (en) 2001-03-15
GC0000203A (en) 2006-03-29
UY26329A1 (es) 2001-07-31
TR200200614T2 (tr) 2002-07-22
HUP0202710A2 (hu) 2002-12-28
JP4685307B2 (ja) 2011-05-18
ES2234658T3 (es) 2005-07-01
PT1218005E (pt) 2005-05-31
IL148325A0 (en) 2002-09-12
PL354176A1 (en) 2003-12-29
AR025589A1 (es) 2002-12-04
ATE284870T1 (de) 2005-01-15
CN1377269A (zh) 2002-10-30
TWI255813B (en) 2006-06-01
KR100711170B1 (ko) 2007-04-27
EP1218005B1 (en) 2004-12-15
DE60016769D1 (de) 2005-01-20
KR20020027624A (ko) 2002-04-13
AU7354300A (en) 2001-04-10

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090907