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HK1049003B - 用於治療心律失常的新型氧雜雙皮丁化合物 - Google Patents

用於治療心律失常的新型氧雜雙皮丁化合物 Download PDF

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Publication number
HK1049003B
HK1049003B HK03101241.2A HK03101241A HK1049003B HK 1049003 B HK1049003 B HK 1049003B HK 03101241 A HK03101241 A HK 03101241A HK 1049003 B HK1049003 B HK 1049003B
Authority
HK
Hong Kong
Prior art keywords
oxa
diazabicyclo
compound
benzonitrile
formula
Prior art date
Application number
HK03101241.2A
Other languages
German (de)
English (en)
French (fr)
Other versions
HK1049003A1 (zh
Inventor
Bjore Annika
Bjorsne Magnus
Cladingboel David
Hoffman Kurt-Jurgen
Pavey John
Pontan Fritiof
Strandlund Gert
Svensson Peder
Thomson Colin
Wilstermann Michael
Original Assignee
阿斯特拉曾尼卡有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 阿斯特拉曾尼卡有限公司 filed Critical 阿斯特拉曾尼卡有限公司
Publication of HK1049003A1 publication Critical patent/HK1049003A1/zh
Publication of HK1049003B publication Critical patent/HK1049003B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK03101241.2A 1999-10-18 2000-10-13 用於治療心律失常的新型氧雜雙皮丁化合物 HK1049003B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds
SE9903759-0 1999-10-18
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Publications (2)

Publication Number Publication Date
HK1049003A1 HK1049003A1 (zh) 2003-04-25
HK1049003B true HK1049003B (zh) 2005-09-09

Family

ID=20417401

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03101241.2A HK1049003B (zh) 1999-10-18 2000-10-13 用於治療心律失常的新型氧雜雙皮丁化合物

Country Status (41)

Country Link
US (6) US6559143B1 (zh)
EP (2) EP1559717A3 (zh)
JP (3) JP3973906B2 (zh)
KR (1) KR100796142B1 (zh)
CN (2) CN100379743C (zh)
AP (1) AP1536A (zh)
AR (2) AR026064A1 (zh)
AT (1) ATE292134T1 (zh)
AU (1) AU769513B2 (zh)
BG (1) BG65785B1 (zh)
BR (1) BR0014804A (zh)
CA (1) CA2386910A1 (zh)
CO (1) CO5271655A1 (zh)
CU (1) CU23210A3 (zh)
CZ (1) CZ20021328A3 (zh)
DE (1) DE60019158T2 (zh)
DK (1) DK1235831T3 (zh)
EA (1) EA005319B1 (zh)
EE (1) EE04854B1 (zh)
ES (1) ES2239047T3 (zh)
HK (1) HK1049003B (zh)
HR (1) HRP20020336B1 (zh)
HU (1) HUP0204085A3 (zh)
IL (5) IL149108A0 (zh)
IS (2) IS2224B (zh)
MX (1) MXPA02003848A (zh)
MY (1) MY130661A (zh)
NO (1) NO327977B1 (zh)
NZ (2) NZ531260A (zh)
OA (1) OA12067A (zh)
PL (1) PL354970A1 (zh)
PT (1) PT1235831E (zh)
RS (1) RS50760B (zh)
SE (1) SE9903759D0 (zh)
SI (1) SI1235831T1 (zh)
SK (1) SK286723B6 (zh)
TR (1) TR200201059T2 (zh)
TW (1) TWI283680B (zh)
UA (1) UA75052C2 (zh)
WO (1) WO2001028992A2 (zh)
ZA (1) ZA200202575B (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
JP2005514376A (ja) * 2001-11-22 2005-05-19 アストラゼネカ アクチボラグ ２−アミノメチル−２，３−ジヒドロオキサジンからの２−又は−９−オキサ−３，７−ジアザビシクロ（３．３．１）ノナンの調製のための方法、その中間体、及びこのような中間体を調製するための方法
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401540D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
JP2008543750A (ja) * 2005-06-13 2008-12-04 アストラゼネカ アクチボラグ 心不整脈の処置用の新規オキサビスピジン化合物
AR054284A1 (es) * 2005-06-20 2007-06-13 Astrazeneca Ab Procedimiento para la preparacion de sales de acido sulfonico de oxabispidinas
WO2006137770A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of n,n´- disubstituted oxabispidines
AR054391A1 (es) * 2005-06-20 2007-06-20 Astrazeneca Ab Procedimiento para la preparacion de 3,7- dihidroxi-1,5-diazaciclooctanos
AR053901A1 (es) * 2005-06-20 2007-05-23 Astrazeneca Ab Formas fisicas de oxabispidinas n,n'- disustituidas
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
BR112015021985B1 (pt) 2013-03-15 2022-12-13 Global Blood Therapeutics, Inc Compostos ou sais farmaceuticamente aceitáveis dos mesmos, respectivos usos e composição
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
WO2016054123A1 (en) 2014-09-30 2016-04-07 Lightner Derek Methods of producing heteropolycycles via bis-epoxidation
JP2023101256A (ja) * 2022-01-07 2023-07-20 三菱ケミカル株式会社 エポキシ樹脂組成物及び硬化物
JP7800143B2 (ja) * 2022-01-07 2026-01-16 三菱ケミカル株式会社 エポキシ樹脂組成物及び硬化物

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
US3196154A (en) 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) * 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
FI67320C (fi) * 1983-05-09 1985-03-11 Partek Ab Foerfarande och glidgjutanordning foer gjutning av betongstycken
JPS6284071A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規グリシジル化合物及びその製造方法
JPS6284070A (ja) 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規なグリシジル化合物及びその製造法
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en) 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FR2664270B1 (fr) * 1990-07-09 1994-04-08 Norsolor Sa Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
JP2602745B2 (ja) * 1991-06-26 1997-04-23 花王株式会社 フレキシブルディスク用センターハブのピッキング装置
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5831099A (en) 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
HUP0202214A3 (en) 1999-04-09 2002-12-28 Astrazeneca Ab Adamantane derivatives, preparation and use thereof
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE9904765D0 (sv) * 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Also Published As

Publication number Publication date
OA12067A (en) 2006-05-04
TR200201059T2 (tr) 2002-09-23
ES2239047T3 (es) 2005-09-16
US20060166979A1 (en) 2006-07-27
PL354970A1 (en) 2004-03-22
HRP20020336A2 (en) 2004-02-29
BG65785B1 (bg) 2009-11-30
IL149108A0 (en) 2002-11-10
NO20021811L (no) 2002-06-06
IL183852A0 (en) 2009-02-11
NZ518156A (en) 2004-05-28
UA75052C2 (en) 2006-03-15
HUP0204085A2 (hu) 2003-04-28
EP1559717A3 (en) 2009-04-29
NO327977B1 (no) 2009-11-02
EP1559717A2 (en) 2005-08-03
IL183854A0 (en) 2009-02-11
US7351821B2 (en) 2008-04-01
PT1235831E (pt) 2005-06-30
HK1049003A1 (zh) 2003-04-25
WO2001028992A2 (en) 2001-04-26
AP1536A (en) 2006-01-09
AU1069101A (en) 2001-04-30
AR026064A1 (es) 2002-12-26
EE200200203A (et) 2003-06-16
CU23210A3 (es) 2007-06-20
EA200200390A1 (ru) 2002-10-31
SK5062002A3 (en) 2002-11-06
BR0014804A (pt) 2002-06-11
ZA200202575B (en) 2003-09-23
HUP0204085A3 (en) 2006-01-30
IS8586A (is) 2006-12-27
ATE292134T1 (de) 2005-04-15
NO20021811D0 (no) 2002-04-17
IS2224B (is) 2007-04-15
BG106588A (en) 2003-01-31
JP3973906B2 (ja) 2007-09-12
US7772229B2 (en) 2010-08-10
DE60019158D1 (de) 2005-05-04
CN101265262A (zh) 2008-09-17
TWI283680B (en) 2007-07-11
YU29402A (sh) 2004-12-31
KR100796142B1 (ko) 2008-01-21
HRP20020336B1 (en) 2006-02-28
CA2386910A1 (en) 2001-04-26
CZ20021328A3 (cs) 2002-09-11
JP2006342182A (ja) 2006-12-21
US20030153564A1 (en) 2003-08-14
WO2001028992A3 (en) 2001-09-13
MY130661A (en) 2007-07-31
SE9903759D0 (sv) 1999-10-18
SK286723B6 (sk) 2009-04-06
US20070117799A1 (en) 2007-05-24
EE04854B1 (et) 2007-06-15
DE60019158T2 (de) 2006-02-02
IL183853A0 (en) 2009-02-11
EP1235831B1 (en) 2005-03-30
CN1399639A (zh) 2003-02-26
KR20020038956A (ko) 2002-05-24
SI1235831T1 (zh) 2005-08-31
MXPA02003848A (es) 2002-10-23
US20060166980A1 (en) 2006-07-27
US20090326221A1 (en) 2009-12-31
RS50760B (sr) 2010-08-31
AR039226A2 (es) 2005-02-09
AU769513B2 (en) 2004-01-29
EA005319B1 (ru) 2005-02-24
US7164017B2 (en) 2007-01-16
EP1235831A2 (en) 2002-09-04
NZ531260A (en) 2005-08-26
US6559143B1 (en) 2003-05-06
JP2003512352A (ja) 2003-04-02
IL149108A (en) 2009-12-24
CN100379743C (zh) 2008-04-09
CO5271655A1 (es) 2003-04-30
AP2002002471A0 (en) 2002-06-30
DK1235831T3 (da) 2005-06-27
IS6346A (is) 2002-04-17
JP2007204486A (ja) 2007-08-16

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20101013