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HK1043321B - 应用大环内酯化合物治疗乾眼症 - Google Patents

应用大环内酯化合物治疗乾眼症 Download PDF

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Publication number
HK1043321B
HK1043321B HK02105192.3A HK02105192A HK1043321B HK 1043321 B HK1043321 B HK 1043321B HK 02105192 A HK02105192 A HK 02105192A HK 1043321 B HK1043321 B HK 1043321B
Authority
HK
Hong Kong
Prior art keywords
hydrogen atom
hydroxy
alkyl
atom
group
Prior art date
Application number
HK02105192.3A
Other languages
German (de)
English (en)
French (fr)
Other versions
HK1043321A1 (zh
Inventor
Ueno Ryuji
Original Assignee
苏坎波公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22452015&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1043321(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 苏坎波公司 filed Critical 苏坎波公司
Publication of HK1043321A1 publication Critical patent/HK1043321A1/zh
Publication of HK1043321B publication Critical patent/HK1043321B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
HK02105192.3A 1999-04-30 2000-04-26 应用大环内酯化合物治疗乾眼症 HK1043321B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13200999P 1999-04-30 1999-04-30
US60/132,009 1999-04-30
PCT/JP2000/002756 WO2000066122A1 (en) 1999-04-30 2000-04-26 Use of macrolide compounds for the treatment of dry eye

Publications (2)

Publication Number Publication Date
HK1043321A1 HK1043321A1 (zh) 2002-09-13
HK1043321B true HK1043321B (zh) 2005-07-15

Family

ID=22452015

Family Applications (2)

Application Number Title Priority Date Filing Date
HK02105192.3A HK1043321B (zh) 1999-04-30 2000-04-26 应用大环内酯化合物治疗乾眼症
HK02107726.4A HK1046099A1 (zh) 1999-04-30 2000-04-26 用於治疗乾眼的大环内酯化合物的应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK02107726.4A HK1046099A1 (zh) 1999-04-30 2000-04-26 用於治疗乾眼的大环内酯化合物的应用

Country Status (23)

Country Link
EP (1) EP1173177B2 (zh)
JP (2) JP5036934B2 (zh)
KR (1) KR20020015316A (zh)
CN (1) CN1190194C (zh)
AR (1) AR023807A1 (zh)
AT (1) ATE281167T1 (zh)
AU (1) AU777915B2 (zh)
BR (1) BR0011225A (zh)
CA (1) CA2372448A1 (zh)
CZ (1) CZ20013769A3 (zh)
DE (1) DE60015516T2 (zh)
ES (1) ES2232439T3 (zh)
HK (2) HK1043321B (zh)
HU (1) HUP0200864A3 (zh)
IL (1) IL146162A0 (zh)
MX (1) MXPA01010988A (zh)
NO (1) NO20015288D0 (zh)
NZ (1) NZ515339A (zh)
PT (1) PT1173177E (zh)
TR (1) TR200103119T2 (zh)
TW (1) TWI230066B (zh)
WO (1) WO2000066122A1 (zh)
ZA (1) ZA200108905B (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20013769A3 (cs) * 1999-04-30 2002-03-13 Sucampo Ag Činidlo pro léčbu suchého oka
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
EP1406700A1 (en) 2001-07-06 2004-04-14 Sucampo AG Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent
TWI324925B (en) * 2001-08-23 2010-05-21 Novartis Ag Ophthalmic composition
AR038628A1 (es) * 2002-03-04 2005-01-19 Novartis Ag Composicion oftalmica
JP2005536531A (ja) * 2002-08-09 2005-12-02 スキャンポ ファーマシューティカルズ、インコーポレイテッド アレルギー性疾患を処置する為のｆｋ５０６誘導体を含む医薬組成物及びその使用
US7354574B2 (en) 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
WO2004062669A1 (en) * 2003-01-16 2004-07-29 Sucampo Ag Use of a macrolide compound for treating dry eye
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
US7083802B2 (en) * 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
CA2539324A1 (en) 2003-09-18 2005-03-31 Macusight, Inc. Transscleral delivery
US7083803B2 (en) 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US7087237B2 (en) 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
WO2005032534A1 (ja) 2003-10-06 2005-04-14 Ophtecs Corporation 涙液異常の治療のための眼科用組成物
GB2438544A (en) 2005-02-09 2007-11-28 Cooper Internat Corp Liquid formulations for treatment of diseases or conditions
EP1904056B1 (en) 2005-07-18 2009-04-29 Minu, L.L.C. Use of a macrolide to restore corneal sensation
JP5528708B2 (ja) 2006-02-09 2014-06-25 参天製薬株式会社 安定な製剤ならびにそれらを調製および使用する方法
AU2007230964B2 (en) 2006-03-23 2012-07-19 Santen Pharmaceutical Co., Ltd. Formulations and methods for vascular permeability-related diseases or conditions
EP2335735A1 (en) * 2009-12-14 2011-06-22 Novaliq GmbH Pharmaceutical composition for treatment of dry eye syndrome
KR20200069261A (ko) * 2017-05-30 2020-06-16 엑시모어 엘티디. 항생제 마크로라이드를 전달하는 안구건조증을 치료하기 위한 조성물 및 방법
EP3691654A4 (en) 2017-09-25 2021-11-24 Surface Pharmaceuticals, Inc. OPHTHALMIC PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF EYE SURFACE DISEASES
SG11202106967QA (en) 2018-12-27 2021-07-29 Surface Ophthalmics Inc Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease
US12440510B2 (en) 2021-05-10 2025-10-14 Surface Ophthalmics, Inc. Use of chondroitin sulfate for relieving ocular pain
CN117979951A (zh) 2021-05-10 2024-05-03 瑟菲斯眼科股份有限公司 一种用于缓解眼部疼痛的硫酸软骨素的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69016515T2 (de) * 1989-07-05 1995-06-08 Fujisawa Pharmaceutical Co Wässriges flüssiges Mittel zur äusserlichen Anwendung.
US5514686A (en) * 1991-04-26 1996-05-07 Fujisawa Pharmaceutical Co., Ltd. Use of macrolide compounds for eye diseases
IL102414A (en) * 1991-07-25 1996-08-04 Univ Louisville Res Found Medicinal preparations for the treatment of ocular inflammation, containing rapamycin
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
GB9601120D0 (en) * 1996-01-19 1996-03-20 Sandoz Ltd Organic compounds
US6673807B1 (en) * 1998-04-06 2004-01-06 Fujisawa Pharmaceutical Co., Ltd. Immunosuppressive imidazole derivatives and their combination preparations with tacrolimus or cyclosporins
WO1999055332A1 (en) * 1998-04-27 1999-11-04 Fujisawa Pharmaceutical Co., Ltd. Medicinal compositions
US6376517B1 (en) * 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
CZ20013769A3 (cs) * 1999-04-30 2002-03-13 Sucampo Ag Činidlo pro léčbu suchého oka

Also Published As

Publication number Publication date
CN1190194C (zh) 2005-02-23
NZ515339A (en) 2004-02-27
ZA200108905B (en) 2002-12-24
EP1173177B1 (en) 2004-11-03
NO20015288L (no) 2001-10-29
CZ20013769A3 (cs) 2002-03-13
ES2232439T3 (es) 2005-06-01
PT1173177E (pt) 2005-03-31
CN1353608A (zh) 2002-06-12
ATE281167T1 (de) 2004-11-15
KR20020015316A (ko) 2002-02-27
JP2012116857A (ja) 2012-06-21
HUP0200864A3 (en) 2004-07-28
HK1046099A1 (zh) 2002-12-27
HK1043321A1 (zh) 2002-09-13
AU4142900A (en) 2000-11-17
NO20015288D0 (no) 2001-10-29
EP1173177A1 (en) 2002-01-23
IL146162A0 (en) 2002-07-25
CA2372448A1 (en) 2000-11-09
MXPA01010988A (es) 2004-04-21
JP5036934B2 (ja) 2012-09-26
BR0011225A (pt) 2002-03-19
HUP0200864A2 (hu) 2002-07-29
AU777915B2 (en) 2004-11-04
WO2000066122A1 (en) 2000-11-09
TR200103119T2 (tr) 2002-04-22
TWI230066B (en) 2005-04-01
JP2002543132A (ja) 2002-12-17
DE60015516T2 (de) 2005-12-01
DE60015516D1 (de) 2004-12-09
EP1173177B2 (en) 2014-03-05
AR023807A1 (es) 2002-09-04

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090426