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HK1041451B - 一种单相稳定的非水粘性溶剂和使用该溶剂的制剂 - Google Patents

一种单相稳定的非水粘性溶剂和使用该溶剂的制剂 Download PDF

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Publication number
HK1041451B
HK1041451B HK02103234.8A HK02103234A HK1041451B HK 1041451 B HK1041451 B HK 1041451B HK 02103234 A HK02103234 A HK 02103234A HK 1041451 B HK1041451 B HK 1041451B
Authority
HK
Hong Kong
Prior art keywords
formulation according
beneficial agent
formulation
vehicle
polymer
Prior art date
Application number
HK02103234.8A
Other languages
German (de)
English (en)
French (fr)
Other versions
HK1041451A1 (zh
Inventor
Stephen A. Berry
Pamela J. Fereira
Houdin Dehnad
Anna Muchnik
Original Assignee
Intarcia Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22382917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1041451(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intarcia Therapeutics, Inc. filed Critical Intarcia Therapeutics, Inc.
Publication of HK1041451A1 publication Critical patent/HK1041451A1/zh
Publication of HK1041451B publication Critical patent/HK1041451B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
HK02103234.8A 1999-02-08 2000-02-02 一种单相稳定的非水粘性溶剂和使用该溶剂的制剂 HK1041451B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11917099P 1999-02-08 1999-02-08
US60/119170 1999-02-08
PCT/US2000/002772 WO2000045790A2 (en) 1999-02-08 2000-02-02 Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles

Publications (2)

Publication Number Publication Date
HK1041451A1 HK1041451A1 (zh) 2002-07-12
HK1041451B true HK1041451B (zh) 2006-12-01

Family

ID=22382917

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02103234.8A HK1041451B (zh) 1999-02-08 2000-02-02 一种单相稳定的非水粘性溶剂和使用该溶剂的制剂

Country Status (22)

Country Link
EP (2) EP1666026B2 (zh)
JP (1) JP4861551B2 (zh)
KR (2) KR20080045300A (zh)
CN (1) CN1232244C (zh)
AR (1) AR029613A1 (zh)
AT (2) ATE537811T1 (zh)
AU (1) AU775904B2 (zh)
CA (1) CA2361424C (zh)
CO (1) CO5140096A1 (zh)
CY (1) CY1119950T1 (zh)
DE (1) DE60027272T2 (zh)
DK (1) DK1666026T4 (zh)
ES (2) ES2379471T5 (zh)
HK (1) HK1041451B (zh)
HU (1) HUP0200202A3 (zh)
IL (1) IL144755A0 (zh)
NO (1) NO20013861L (zh)
NZ (1) NZ513441A (zh)
PT (2) PT1666026E (zh)
TW (2) TW200730199A (zh)
WO (1) WO2000045790A2 (zh)
ZA (1) ZA200106443B (zh)

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Publication number Publication date
AU775904B2 (en) 2004-08-19
ZA200106443B (en) 2002-08-06
ATE537811T1 (de) 2012-01-15
DK1666026T3 (da) 2012-04-10
EP1666026A2 (en) 2006-06-07
TW200730199A (en) 2007-08-16
NZ513441A (en) 2004-01-30
JP4861551B2 (ja) 2012-01-25
EP1666026B2 (en) 2015-02-25
CY1119950T1 (el) 2018-12-12
CA2361424A1 (en) 2000-08-10
HUP0200202A2 (hu) 2002-05-29
CA2361424C (en) 2009-04-28
ES2261190T3 (es) 2006-11-16
NO20013861L (no) 2001-09-20
ES2379471T5 (es) 2015-05-26
WO2000045790A2 (en) 2000-08-10
CN1232244C (zh) 2005-12-21
HUP0200202A3 (en) 2009-08-28
NO20013861D0 (no) 2001-08-08
EP1152749A2 (en) 2001-11-14
KR20080045300A (ko) 2008-05-22
EP1666026A3 (en) 2007-08-08
CN1339962A (zh) 2002-03-13
DE60027272T2 (de) 2007-01-25
DE60027272D1 (de) 2006-05-24
IL144755A0 (en) 2002-06-30
AU3481600A (en) 2000-08-25
EP1152749B1 (en) 2006-04-12
ATE322889T1 (de) 2006-04-15
HK1094528A1 (zh) 2007-04-04
CO5140096A1 (es) 2002-03-22
JP2002536315A (ja) 2002-10-29
AR029613A1 (es) 2003-07-10
PT1666026E (pt) 2012-03-15
EP1666026B1 (en) 2011-12-21
HK1041451A1 (zh) 2002-07-12
WO2000045790A3 (en) 2000-12-07
ES2379471T3 (es) 2012-04-26
TWI292716B (en) 2008-01-21
KR100858856B1 (ko) 2008-09-17
DK1666026T4 (da) 2015-05-04
PT1152749E (pt) 2006-08-31
KR20010101842A (ko) 2001-11-14

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