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GT200600179A - Proceso para preparar oxindoles y tio-oxindoles 3,3-disustituidos - Google Patents

Proceso para preparar oxindoles y tio-oxindoles 3,3-disustituidos

Info

Publication number
GT200600179A
GT200600179A GT200600179A GT200600179A GT200600179A GT 200600179 A GT200600179 A GT 200600179A GT 200600179 A GT200600179 A GT 200600179A GT 200600179 A GT200600179 A GT 200600179A GT 200600179 A GT200600179 A GT 200600179A
Authority
GT
Guatemala
Prior art keywords
oxindols
prepare
compounds
disustituted
thio
Prior art date
Application number
GT200600179A
Other languages
English (en)
Inventor
Bogdan Kazimierz Wilk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200600179A publication Critical patent/GT200600179A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE PROPORCIONAN MÉTODOS PARA PREPARAR COMPUESTOS DE OXINDOL Y TIO-OXINDOL, COMPUESTOS QUE SON ÚTILES COMO PRECURSORES DE COMPUESTOS FARMACÉUTICOS ÚTILES. SE PROPORCIONAN ESPECÍFICAMENTE MÉTODOS PARA PREPARAR COMPUESTOS DE 5-PIRROL-3,3-OXINDOL Y 5-(7-FLUORO-3,3-DIMETIL-2-OXO-2,3-DIHIDRO-1H-INDOL-5-IL)-1-METIL-1-H-PIRROL-2-CARBONITRILO. TAMBIÉN SE PROPORCIONAN MÉTODOS PARA PREPARAR COMPUESTOS DE IMINOBENZO[B]TIOFENO Y BENZO[B]TIOFENONA.
GT200600179A 2005-04-29 2006-04-27 Proceso para preparar oxindoles y tio-oxindoles 3,3-disustituidos GT200600179A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67638105P 2005-04-29 2005-04-29

Publications (1)

Publication Number Publication Date
GT200600179A true GT200600179A (es) 2006-11-22

Family

ID=36937284

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200600179A GT200600179A (es) 2005-04-29 2006-04-27 Proceso para preparar oxindoles y tio-oxindoles 3,3-disustituidos

Country Status (12)

Country Link
US (1) US7595338B2 (es)
EP (1) EP1877377A2 (es)
JP (1) JP2008540337A (es)
CN (1) CN101166722A (es)
AU (1) AU2006242542A1 (es)
BR (1) BRPI0608221A2 (es)
CA (1) CA2603818A1 (es)
GT (1) GT200600179A (es)
MX (1) MX2007013450A (es)
PE (1) PE20061370A1 (es)
TW (1) TW200716517A (es)
WO (1) WO2006118955A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
PE20070220A1 (es) * 2005-07-29 2007-03-19 Wyeth Corp Proceso para la sintesis de moduladores del receptor de progesterona
CL2007002953A1 (es) * 2006-10-12 2008-02-01 Xenon Pharmaceuticals Inc Compuestos derivados de espiro-oxindol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del dolor, cancer, prurito, hiperplasia prostatica benigna, hipercolesterolemia.
AR063280A1 (es) * 2006-10-12 2009-01-21 Xenon Pharmaceuticals Inc Uso de compuestos de espiro-oxindol como agentes terapeuticos
JP2010522690A (ja) * 2006-10-12 2010-07-08 ゼノン・ファーマシューティカルズ・インコーポレイテッド 三環式スピロオキシインドール誘導体および治療薬としてのその使用
US20080312306A1 (en) * 2007-06-15 2008-12-18 Wyeth Polymorphs, solvates, and hydrate of 5-(4'-fluoro-2'-oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indol]-5'-yl)-1-methyl-1h-pyrrole-2-carbonitrile
US20080319204A1 (en) * 2007-06-25 2008-12-25 Wyeth Process for the synthesis of progesterone receptor modulators
BRPI0819571A2 (pt) * 2007-12-20 2019-09-24 Teva Womenss Health Inc "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica"
CA2741029A1 (en) * 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
CA2741024A1 (en) * 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
EA201101621A1 (ru) 2009-05-15 2012-05-30 Новартис Аг Производные бензоксазолона в качестве ингибиторов альдостеронсинтазы
BRPI1012203A2 (pt) 2009-05-15 2016-04-05 Novartis Ag derivados de 5-piridin-3-il-1,3-di-hidro-indol-2-ona e seu uso como moduladores da aldosterona sintase e/ou da cyp11b1
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
NZ599334A (en) 2009-10-14 2014-03-28 Xenon Pharmaceuticals Inc Synthetic methods for spiro-oxindole compounds
RU2596488C2 (ru) 2010-02-26 2016-09-10 Ксенон Фармасьютикалз Инк. Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов
JP2013540736A (ja) * 2010-09-16 2013-11-07 エフ．ホフマン−ラ ロシュ アーゲー 新規プロセス
US8933248B2 (en) 2012-06-21 2015-01-13 Council Of Scientific & Industrial Research 3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
CN103936649B (zh) * 2014-03-29 2016-05-04 贵州大学 3-(2-丙烯酸酯)-3-硫代氧化吲哚化合物及其制备方法
US10336698B2 (en) 2015-01-22 2019-07-02 Sanofi-Aventis Deutschland Gmbh Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile
US9682033B2 (en) 2015-02-05 2017-06-20 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
RU2601749C1 (ru) * 2015-09-08 2016-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный технический университет" (ВолгГТУ) Способ получения 4'-фторспиро[циклопропан-1,3'-индол]-2'(1'н)-она
WO2019099760A1 (en) * 2017-11-16 2019-05-23 University Of Houston System Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732278A (en) 1970-12-02 1973-05-08 Us Navy Ethyl(4-trifluoromethyl-2,3,5,6-tetra-fluorophenyl)cyanoacetate
EP0010879B2 (en) 1978-10-27 1991-12-11 Imperial Chemical Industries Plc Halogenated esters of cyclopropane acids, their preparation, compositions and use as pesticides
DE3015587A1 (de) 1980-04-23 1981-10-29 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von acylcyaniden
FR2482955A1 (fr) 1980-05-23 1981-11-27 Roussel Uclaf Nouveaux derives de l'acide cyclopropane carboxylique, leur procede de preparation et leur application a la lutte contre les parasites
US4866185A (en) 1986-04-18 1989-09-12 Ici Americas Inc. Difunctional polyfluoroaromatic derivatives and a process of preparing the same
US4783547A (en) 1986-04-18 1988-11-08 Ici Americas Inc. Polyfluoroaromatic nitriles
US4965394A (en) 1986-04-18 1990-10-23 Ici Americas Inc. Difunctional polyfluoroaromatic derivatives and a process of preparing the same
US5231109A (en) 1986-09-10 1993-07-27 Bayer Aktiengesellschaft 2-cyano-2-alkoximino-acetamides
DE3630732A1 (de) 1986-09-10 1988-03-17 Bayer Ag 2-cyano-2-alkoximino-acetamide
US5288732A (en) 1986-09-10 1994-02-22 Bayer Aktiengesellschaft 2-cyano-2-alkoximino-acetamides
FR2610624B1 (fr) 1987-02-06 1989-06-09 Roussel Uclaf Nouveaux esters d'acides cyclopropanecarboxyliques apparentes a l'acide pyrethrique, leur procede de preparation et leur application a la lutte contre les parasites
DE3735821A1 (de) 1987-10-22 1989-05-03 Peroxid Chemie Gmbh Verfahren zur polymerisation von ethylen unter erhoehtem druck
DE3909213A1 (de) 1989-03-21 1990-10-11 Bayer Ag Halogenbenzolderivate
GB9125791D0 (en) 1991-12-04 1992-02-05 Schering Agrochemicals Ltd Herbicides
WO1994008982A1 (fr) 1992-10-13 1994-04-28 Nippon Soda Co., Ltd. Derives oxazole et thiazole
US5545769A (en) 1994-09-29 1996-08-13 E. I. Du Pont De Nemours And Company Process for the manufacture of selected halogenated hydrocarbons containing fluorine and hydrogen and compositions provided therein
CN1070845C (zh) 1994-12-19 2001-09-12 日本曹达株式会社 苄胺肟衍生物及其制备方法和农业及园艺用杀菌剂
FR2734564B1 (fr) 1995-05-24 1997-07-04 Rhone Poulenc Chimie Procede d'hydroxyalkylation d'un ether aromatique
BR9609924A (pt) 1995-08-01 1999-06-08 Du Pont Processo em fase líquida para produzir adutos de alcano halogenados processo para produção de um hidrofluoroalcano processo para produção de cf<3>ch<2>chf<2> composicão azeótropo compostos e processo para purificação de pelo menos um composto
DE19529089A1 (de) 1995-08-08 1997-02-13 Bayer Ag Mercapto-triazolyl-nitrile
FR2739098B1 (fr) 1995-09-25 1997-11-28 Rhone Poulenc Chimie Procede d'acylation d'un compose aromatique
FR2745287B1 (fr) 1996-02-28 1998-04-10 Rhone Poulenc Chimie Nouvelle composition catalytique et sa mise en oeuvre dans un procede d'acylation d'un compose aromatique
FR2745285B1 (fr) 1996-02-28 1998-04-10 Rhone Poulenc Chimie Nouveau catalyseur de c-alkylation d'un compose aromatique et son utilisation
US6005118A (en) 1996-05-03 1999-12-21 Caron; Stephane Methods of preparing 4-cyano-4 (substituted indazole) cyclohexane-carboxylic acids useful as PDE4 inhibitors
US6040487A (en) 1996-07-31 2000-03-21 E. I. Du Pont De Nemours And Company Process for the manufacture of halocarbons
IT1284926B1 (it) 1996-10-08 1998-05-28 Isagro Spa Composizioni fungicide e loro utilizzo per il controllo di funghi fitopatogeni
DE19835943A1 (de) 1998-08-08 2000-02-10 Bayer Ag Substituierte Triazinone
US6303782B1 (en) * 1999-04-20 2001-10-16 Pfizer Inc Process for preparing benzylnitriles
DE10038639A1 (de) 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
AU8447301A (en) 2000-09-19 2002-04-02 Sumitomo Chemical Co Pyrimidine compounds and their use
US7276526B2 (en) 2001-07-13 2007-10-02 Bristol-Myers Squibb Pharma Company Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands
US6482983B1 (en) * 2001-07-31 2002-11-19 Millennium Specialty Chemicals Process for obtaining N-monosubstituted amides
AR039208A1 (es) 2002-04-03 2005-02-09 Syngenta Participations Ag Compuestos de fenil- y piridilalquinos, composicion herbicida que los contiene, procedimiento de preparacion de aquellos y procedimiento para combatir el crecimiento de plantas indeseadas
US6977131B2 (en) 2002-05-30 2005-12-20 Kodak Polychrome Graphics Llc Selected polymeric sulfonate acid generators and their use in processes for imaging radiation-sensitive elements
US7517899B2 (en) * 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
TW200602293A (en) 2004-04-05 2006-01-16 Merck & Co Inc Process for the preparation of enantiomerically enriched beta amino acid derivatives

Also Published As

Publication number Publication date
WO2006118955A2 (en) 2006-11-09
BRPI0608221A2 (pt) 2009-11-24
PE20061370A1 (es) 2007-01-08
MX2007013450A (es) 2008-01-21
AU2006242542A1 (en) 2006-11-09
JP2008540337A (ja) 2008-11-20
CA2603818A1 (en) 2006-11-09
WO2006118955A3 (en) 2007-01-11
EP1877377A2 (en) 2008-01-16
US7595338B2 (en) 2009-09-29
US20060247441A1 (en) 2006-11-02
CN101166722A (zh) 2008-04-23
TW200716517A (en) 2007-05-01

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