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GT200000161A - Compuestos para el tratamiento de la isquemia. - Google Patents

Compuestos para el tratamiento de la isquemia.

Info

Publication number
GT200000161A
GT200000161A GT200000161A GT200000161A GT200000161A GT 200000161 A GT200000161 A GT 200000161A GT 200000161 A GT200000161 A GT 200000161A GT 200000161 A GT200000161 A GT 200000161A GT 200000161 A GT200000161 A GT 200000161A
Authority
GT
Guatemala
Prior art keywords
compounds
agonists
profarmacos
discussion
ischemia
Prior art date
Application number
GT200000161A
Other languages
English (en)
Inventor
Hiroko Masamune
Michael Paul Deninno
Robert William Scott
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200000161A publication Critical patent/GT200000161A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28Oxygen atom
    • C07D473/30Oxygen atom attached in position 6, e.g. hypoxanthine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA ADJUNTA, PROFARMACOS DE LOS MISMOS Y SALES FARMACEUTICAMENTE ACEPTABLES DE DICHOS COMPUESTOS Y DE DICHOS PROFARMACOS, EN LA QUE X = OXI, METILENO O TIO; Y = CH O N; Z = ES H, ALQUILO, TRIFLUOROMETILO O HALO; LAS DEMAS LETRAS REPRESENTAN UNA GRAN VARIEDAD DE SUSTITUYENTES QUE INDIVIDUAL O CONJUNTAMENTE FORMAN PARTE DE LAS CARACTERISTICAS DE ESTE INGREDIENTE ACTIVO Y DEBERAN COTEJARSE EN EL DOCUMENTO ORIGINAL, LOS COMPUESTOS SON AGONISTAS DE A3 UTILES PARA LA REDUCCION DE LESIONES DE TEJIDOS PRODUCIDAS POR ISQUEMIA O HIPOXIA DE LOS TEJIDOS. EL INVENTO REIVINDICA ADEMAS DEL PROCEDIMIENTO DE SINTESIS DE LOS DIFERENTES COMPUESTOS, LOS PROCEDIMIENTOS PARA USAR TALES AGONISTAS, Y COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES AGONISTAS DE A3.
GT200000161A 1999-09-30 2000-09-28 Compuestos para el tratamiento de la isquemia. GT200000161A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15682899P 1999-09-30 1999-09-30

Publications (1)

Publication Number Publication Date
GT200000161A true GT200000161A (es) 2002-03-22

Family

ID=22561263

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200000161A GT200000161A (es) 1999-09-30 2000-09-28 Compuestos para el tratamiento de la isquemia.

Country Status (41)

Country Link
EP (1) EP1216257B1 (es)
JP (1) JP2003510331A (es)
KR (1) KR100481605B1 (es)
CN (1) CN1374967A (es)
AP (1) AP2002002458A0 (es)
AR (1) AR029887A1 (es)
AT (1) ATE312117T1 (es)
AU (1) AU778185B2 (es)
BG (1) BG106636A (es)
BR (1) BR0014384A (es)
CA (1) CA2386079A1 (es)
CO (1) CO5180581A1 (es)
CR (1) CR6592A (es)
CZ (1) CZ20021020A3 (es)
DE (1) DE60024649D1 (es)
EA (1) EA005422B1 (es)
EC (1) ECSP003682A (es)
EE (1) EE200200172A (es)
GE (1) GEP20043241B (es)
GT (1) GT200000161A (es)
HK (1) HK1049011A1 (es)
HR (1) HRP20020253A2 (es)
HU (1) HUP0202807A3 (es)
IL (1) IL148222A0 (es)
IS (1) IS6286A (es)
MA (1) MA26822A1 (es)
MX (1) MXPA02003308A (es)
MY (1) MY133996A (es)
NO (1) NO20021474L (es)
NZ (1) NZ517177A (es)
OA (1) OA12021A (es)
PA (1) PA8503301A1 (es)
PE (1) PE20010696A1 (es)
PL (1) PL357371A1 (es)
SK (1) SK4182002A3 (es)
TN (1) TNSN00191A1 (es)
TR (1) TR200200843T2 (es)
UA (1) UA73525C2 (es)
WO (1) WO2001023399A1 (es)
YU (1) YU23102A (es)
ZA (1) ZA200202461B (es)

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GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
KR20070085093A (ko) 2004-03-24 2007-08-27 파스젠, 엘엘씨. Amp-활성화 단백질 키나아제의 약리학적 저해에 의한신규한 신경 보호 방법
NZ551077A (en) 2004-05-07 2009-05-31 Janssen Pharmaceutica Nv Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
JP4642847B2 (ja) * 2004-07-28 2011-03-02 キャン−ファイト・バイオファーマ・リミテッド シェーグレン症候群を含むドライアイ疾患治療用アデノシンa3レセプターアゴニスト
CA2576255A1 (en) * 2004-08-09 2006-02-16 Universite Catholique De Louvain Use of agonists and antagonists of beta-adrenoceptors for treating arterial diseases
JP5208505B2 (ja) * 2004-08-30 2013-06-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 11−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのn−2アダマンタニル−2−フェノキシ−アセトアミド誘導体
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GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
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AU2007315234A1 (en) 2006-10-30 2008-05-08 Novartis Ag Heterocyclic compounds as antiinflammatory agents
CN101910153B (zh) 2008-01-11 2014-01-22 诺华股份有限公司 作为激酶抑制剂的嘧啶类
PT2391366E (pt) 2009-01-29 2013-02-05 Novartis Ag Benzimidazoles substituídos para o tratamento de astrocitomas
EP2456419B1 (en) 2009-07-21 2016-11-23 Oradin Pharmaceutical Ltd. A3 adenosine receptor ligands for modulation of pigmentation
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
BR112012003262A8 (pt) 2009-08-12 2016-05-17 Novartis Ag compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação
PE20121148A1 (es) 2009-08-17 2012-09-07 Intellikine Llc Compuestos heterociclicos y usos de los mismos
BR112012008061A2 (pt) 2009-08-20 2016-03-01 Novartis Ag compostos de oxima heterocíclica
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
EP2673277A1 (en) 2011-02-10 2013-12-18 Novartis AG [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase
JP5808826B2 (ja) 2011-02-23 2015-11-10 インテリカイン, エルエルシー 複素環化合物およびその使用
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EP2755976B1 (en) 2011-09-15 2018-07-18 Novartis AG 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors
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Also Published As

Publication number Publication date
HRP20020253A2 (en) 2004-04-30
HUP0202807A2 (hu) 2002-12-28
EA200200316A1 (ru) 2002-08-29
AU778185B2 (en) 2004-11-18
MA26822A1 (fr) 2004-12-20
PE20010696A1 (es) 2001-07-05
CZ20021020A3 (cs) 2003-04-16
WO2001023399A1 (en) 2001-04-05
BR0014384A (pt) 2002-07-02
TR200200843T2 (tr) 2002-07-22
EP1216257A1 (en) 2002-06-26
ATE312117T1 (de) 2005-12-15
EP1216257B1 (en) 2005-12-07
YU23102A (sh) 2006-01-16
JP2003510331A (ja) 2003-03-18
HK1049011A1 (zh) 2003-04-25
UA73525C2 (en) 2005-08-15
ZA200202461B (en) 2003-05-28
HUP0202807A3 (en) 2005-02-28
NO20021474D0 (no) 2002-03-25
CA2386079A1 (en) 2001-04-05
PL357371A1 (en) 2004-07-26
AU7035200A (en) 2001-04-30
MY133996A (en) 2007-11-30
DE60024649D1 (de) 2006-01-12
CR6592A (es) 2004-02-23
EE200200172A (et) 2003-06-16
ECSP003682A (es) 2002-04-23
MXPA02003308A (es) 2002-10-04
IL148222A0 (en) 2002-09-12
NZ517177A (en) 2003-10-31
PA8503301A1 (es) 2003-06-30
NO20021474L (no) 2002-05-22
CN1374967A (zh) 2002-10-16
KR100481605B1 (ko) 2005-04-08
AP2002002458A0 (en) 2002-06-30
CO5180581A1 (es) 2002-07-30
AR029887A1 (es) 2003-07-23
EA005422B1 (ru) 2005-02-24
OA12021A (en) 2006-04-19
GEP20043241B (en) 2004-05-25
SK4182002A3 (en) 2003-04-01
KR20020034206A (ko) 2002-05-08
TNSN00191A1 (fr) 2005-11-10
BG106636A (bg) 2003-01-31
IS6286A (is) 2002-02-26

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