GR3034650T3 - Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use - Google Patents

Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use

Info

Publication number: GR3034650T3
Authority: GR; Greece
Prior art keywords: pharmaceutical compositions; methods; formula; dibenzoxazepine compounds; substituted dibenzoxazepine
Prior art date: 1991-05-03

Application number

GR20000402337T

Other languages

English (en)

Inventor

E Ann Hallinan

Timothy Joseph Hagen

Robert Knol Husa

Sofya Tsymbalov

Albert C Lee

Hoeck Jean Pierre Van

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-03

Filing date

2000-10-20

Publication date

2001-01-31

2000-10-20 Application filed by Searle & Co filed Critical Searle & Co

2001-01-31 Publication of GR3034650T3 publication Critical patent/GR3034650T3/el

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Nutrition Science (AREA)
Cardiology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Transceivers (AREA)
Mobile Radio Communication Systems (AREA)

GR20000402337T 1991-05-03 2000-10-20 Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use GR3034650T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US69565491A	1991-05-03	1991-05-03
EP92914560A EP0583421B1 (en)	1991-05-03	1992-04-16	Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use

Publications (1)

Publication Number	Publication Date
GR3034650T3 true GR3034650T3 (en)	2001-01-31

Family

ID=24793923

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GR990402070T GR3030992T3 (en)	1991-05-03	1999-08-18	Selective system scan for multizone radiotelephone subscriber units.
GR20000402337T GR3034650T3 (en)	1991-05-03	2000-10-20	Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
GR990402070T GR3030992T3 (en)	1991-05-03	1999-08-18	Selective system scan for multizone radiotelephone subscriber units.

Country Status (12)

Country	Link
EP (5)	EP0583421B1 (el)
JP (1)	JP3222891B2 (el)
AT (2)	ATE194987T1 (el)
AU (1)	AU2246292A (el)
CA (1)	CA2108903C (el)
DE (2)	DE69229442T2 (el)
DK (2)	DK0583421T3 (el)
ES (2)	ES2133324T3 (el)
GR (2)	GR3030992T3 (el)
IE (2)	IE921410A1 (el)
PT (2)	PT694546E (el)
WO (1)	WO1992019617A2 (el)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5180720A (en) *	1991-05-03	1993-01-19	G. D. Searle & Co.	2- and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxazepine-10(11H)-carboxylic acid, substituted hydrazides and methods for treating pain
US5378840A (en) *	1992-04-16	1995-01-03	G. D. Searle & Co.	Substituted dibenzoxazepine compounds
US5182272A (en) *	1991-05-03	1993-01-26	G. D. Searle & Co.	8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain
US5212169A (en) *	1991-10-31	1993-05-18	G. D. Searle & Co.	Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
US5304644A (en) *	1992-04-15	1994-04-19	G. D. Searle & Co.	1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
CA2113787A1 (en) *	1993-01-29	1994-07-30	Nobuyuki Hamanaka	Carbocyclic sulfonamides
US5395932A (en) *	1993-04-30	1995-03-07	G. D. Searle & Co.	2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5354746A (en) *	1993-06-01	1994-10-11	G. D. Searle & Co.	Squaric acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5461047A (en) *	1993-06-16	1995-10-24	G. D. Searle & Co.	2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5354747A (en) *	1993-06-16	1994-10-11	G. D. Searle & Co.	2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5420270A (en) *	1993-10-07	1995-05-30	G. D. Searle & Co.	Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5424424A (en) *	1993-10-07	1995-06-13	G. D. Searle & Co.	Tartaric acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5488046A (en) *	1993-11-03	1996-01-30	G. D. Searle & Co.	Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5449675A (en) *	1994-06-09	1995-09-12	G. D. Searle & Co.	Substituted dibenzoxazepine and dibenzthiazepine urea compounds, pharmaceutical compositions and methods of use
US5441950A (en) *	1994-06-09	1995-08-15	G. D. Searle & Co.	Substituted dibenzoxazepine and dibenzthiazepine carbamate compounds, pharmaceutical compositions and methods of use
GB9720270D0 (en)	1997-09-25	1997-11-26	Pharmagene Lab Limited	Medicaments for the treatment of migraine
US7393652B2 (en)	2000-05-10	2008-07-01	The Trustees Of Columbia University In The City Of New York	Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
WO2002072145A1 (en) *	2001-03-14	2002-09-19	Ono Pharmaceutical Co., Ltd.	Remedies for depression containing ep1 antagonist as the active ingredient
EP1447096A1 (en) *	2001-11-19	2004-08-18	Ono Pharmaceutical Co., Ltd.	Remedies for urinary frequency
US7544678B2 (en)	2002-11-05	2009-06-09	The Trustees Of Columbia University In The City Of New York	Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US8598219B2 (en)	2003-01-30	2013-12-03	Helsinn Healthcare Sa	Liquid pharmaceutical formulations of palonosetron
JO2735B1 (en)	2003-01-30	2013-09-15	هيلسين هيلث كير أس ايه.	Liquid pharmaceutical formations of balloonosterone
JP2007525165A (ja)	2003-03-07	2007-09-06	トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク	タイプ１ライアノジン受容体に基づく方法
US8710045B2 (en)	2004-01-22	2014-04-29	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the ryanodine receptors
MX2009008606A (es)	2007-02-16	2009-09-16	Ono Pharmaceutical Co	Agente terapeutico para trastorno de excrecion urinaria.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3624104A (en) *	1969-10-27	1971-11-30	Searle & Co	Aralkanoyl derivatives of dibenzoxazepine-n-carboxylic acid hydrazides
US3917649A (en) *	1971-03-23	1975-11-04	Searle & Co	Dibenzoxazepine N-carboxylic acid hydrazides and derivatives
GB1522003A (en) *	1975-10-17	1978-08-23	Searle & Co	1-acyl-2-(8-chloro-10,11-dihydrodibenz-(b,f)(1,4)-oxazepine-10-carbonyl)hydrazines
US4045442A (en) *	1976-01-05	1977-08-30	G. D. Searle & Co.	1-(Substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines and derivatives thereof
US4704386A (en) *	1985-08-29	1987-11-03	G. D. Searle & Co.	8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(phenylsulfinyl-, and phenylsulfonyl)alkanoyl]hydrazides

1992
- 1992-04-16 ES ES92914560T patent/ES2133324T3/es not_active Expired - Lifetime
- 1992-04-16 DE DE69229442T patent/DE69229442T2/de not_active Expired - Fee Related
- 1992-04-16 AT AT95116871T patent/ATE194987T1/de not_active IP Right Cessation
- 1992-04-16 ES ES95116871T patent/ES2149305T3/es not_active Expired - Lifetime
- 1992-04-16 DK DK92914560T patent/DK0583421T3/da active
- 1992-04-16 EP EP92914560A patent/EP0583421B1/en not_active Expired - Lifetime
- 1992-04-16 DK DK95116871T patent/DK0694545T3/da active
- 1992-04-16 EP EP95116871A patent/EP0694545B1/en not_active Expired - Lifetime
- 1992-04-16 JP JP51183892A patent/JP3222891B2/ja not_active Expired - Fee Related
- 1992-04-16 CA CA002108903A patent/CA2108903C/en not_active Expired - Fee Related
- 1992-04-16 DE DE69231298T patent/DE69231298T2/de not_active Expired - Fee Related
- 1992-04-16 WO PCT/US1992/003028 patent/WO1992019617A2/en not_active Ceased
- 1992-04-16 AT AT92914560T patent/ATE181329T1/de not_active IP Right Cessation
- 1992-04-16 AU AU22462/92A patent/AU2246292A/en not_active Abandoned
- 1992-04-29 PT PT95116872T patent/PT694546E/pt unknown
- 1992-04-29 PT PT99101029T patent/PT911331E/pt unknown
- 1992-04-29 EP EP99101029A patent/EP0911331B1/en not_active Expired - Lifetime
- 1992-04-29 EP EP95116872A patent/EP0694546B1/en not_active Expired - Lifetime
- 1992-04-29 EP EP92107328A patent/EP0512400B1/en not_active Expired - Lifetime
- 1992-07-01 IE IE141092A patent/IE921410A1/en not_active IP Right Cessation
- 1992-07-01 IE IE20000774A patent/IE20000774A1/en not_active IP Right Cessation
1999
- 1999-08-18 GR GR990402070T patent/GR3030992T3/el unknown
2000
- 2000-10-20 GR GR20000402337T patent/GR3034650T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2149305T3 (es)	2000-11-01
PT694546E (pt)	2001-09-28
DK0694545T3 (da)	2000-09-18
EP0694545A3 (en)	1996-03-27
IE921410A1 (en)	1992-11-04
EP0911331A2 (en)	1999-04-28
DE69229442T2 (de)	1999-10-28
EP0583421A1 (en)	1994-02-23
EP0512400A1 (en)	1992-11-11
WO1992019617A2 (en)	1992-11-12
PT911331E (pt)	2004-03-31
EP0911331A3 (en)	2000-01-19
ES2133324T3 (es)	1999-09-16
WO1992019617A3 (en)	1992-12-10
EP0911331B1 (en)	2003-10-22
EP0694546A3 (en)	1996-03-27
EP0694545B1 (en)	2000-07-26
GR3030992T3 (en)	1999-12-31
EP0583421B1 (en)	1999-06-16
EP0512400B1 (en)	1998-12-02
IE20000774A1 (en)	2001-02-21
ATE194987T1 (de)	2000-08-15
EP0694546B1 (en)	2001-06-06
JPH06507408A (ja)	1994-08-25
ATE181329T1 (de)	1999-07-15
CA2108903C (en)	2004-02-10
DK0583421T3 (da)	1999-11-22
AU2246292A (en)	1992-12-21
DE69231298D1 (de)	2000-08-31
EP0694546A2 (en)	1996-01-31
EP0694545A2 (en)	1996-01-31
DE69231298T2 (de)	2001-01-18
JP3222891B2 (ja)	2001-10-29
CA2108903A1 (en)	1992-11-04
DE69229442D1 (de)	1999-07-22

Publication	Publication Date	Title
GR3034650T3 (en)	2001-01-31	Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
CA2029420A1 (en)	1991-05-22	Pharmaceutical compositions and methods for inhibition of maillard's reaction
SI1664041T1 (sl)	2008-12-31	Fenil-karboksamidne spojine, uporabne za tretiranje bolečine
ES2106531T3 (es)	1997-11-01	Compuestos de dibenzoxazepina substituidos en 2, 3, 4, 5, 6, 7, 8, 9 y/o 10, composiciones farmaceuticas y metodos de uso.
DK0533344T3 (el)	1997-03-03
TW222265B (el)	1994-04-11
GR3031114T3 (en)	1999-12-31	Use of a pregnane derivatives for the treatment of tumours.
TW222622B (el)	1994-04-21

Legal Events

Date	Code	Title	Description
2006-11-02	ML	Lapse due to non-payment of fees