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GR1005694B - Tissue-specific antiestrogens specific for estrogen receptor - Google Patents

Tissue-specific antiestrogens specific for estrogen receptor

Info

Publication number
GR1005694B
GR1005694B GR20050100282A GR20050100282A GR1005694B GR 1005694 B GR1005694 B GR 1005694B GR 20050100282 A GR20050100282 A GR 20050100282A GR 20050100282 A GR20050100282 A GR 20050100282A GR 1005694 B GR1005694 B GR 1005694B
Authority
GR
Greece
Prior art keywords
specific
antiestrogens
tissue
estrogen receptor
ability
Prior art date
Application number
GR20050100282A
Other languages
Greek (el)
Other versions
GR20050100282A (en
Inventor
Νικολαος Ασημομυτης
Δεσποινα Συριανη
Original Assignee
Αλεξης Μιχαηλ
Σεκερης Κωνσταντινος
Παπαχατζης Δημητριος
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Αλεξης Μιχαηλ, Σεκερης Κωνσταντινος, Παπαχατζης Δημητριος filed Critical Αλεξης Μιχαηλ
Priority to GR20050100282A priority Critical patent/GR1005694B/en
Publication of GR20050100282A publication Critical patent/GR20050100282A/en
Publication of GR1005694B publication Critical patent/GR1005694B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

The present invention relates to novel analogues of tissue-specific antiestrogens, which show specificity for estrogen receptor as well as methods for producing the same. The new antiestrogens have the ability to act preventively and therapeutically against breast cancer, as evaluated by their ability to bind to two estrogen receptors, (ER) and (ER) and to exhibit antiestrogenic and antineoplastic action on human breast cancer cells and endometrium cells, and finally by their safety resulting from their effect on uterus weight in premature rats. The present invention relates to compounds of Formula (I), wherein R is defined in the description of the invention.
GR20050100282A 2005-06-08 2005-06-08 Tissue-specific antiestrogens specific for estrogen receptor GR1005694B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20050100282A GR1005694B (en) 2005-06-08 2005-06-08 Tissue-specific antiestrogens specific for estrogen receptor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20050100282A GR1005694B (en) 2005-06-08 2005-06-08 Tissue-specific antiestrogens specific for estrogen receptor

Publications (2)

Publication Number Publication Date
GR20050100282A GR20050100282A (en) 2007-01-19
GR1005694B true GR1005694B (en) 2007-10-22

Family

ID=37560958

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20050100282A GR1005694B (en) 2005-06-08 2005-06-08 Tissue-specific antiestrogens specific for estrogen receptor

Country Status (1)

Country Link
GR (1) GR1005694B (en)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117512A1 (en) * 1991-05-25 1992-11-26 Schering Ag 2-PHENYLBENZO (B) FURANES AND THIOPHENES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5484798A (en) * 1994-09-20 1996-01-16 Eli Lilly And Company Benzothiopene compounds, compositions, and method of inhibiting restenosis
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
US6417199B1 (en) * 1995-03-10 2002-07-09 Eli Lilly And Company 3-benzyl-benzothiophenes
US5731342A (en) * 1996-02-22 1998-03-24 Eli Lilly And Company Benzothiophenes, formulations containing same, and methods
JP2000505455A (en) * 1996-02-22 2000-05-09 イーライ・リリー・アンド・カンパニー Benzothiophenes, formulations containing them and methods
US6458811B1 (en) * 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
CA2214872C (en) * 1996-10-24 2002-01-22 Eli Lilly And Company Benzothiophene compounds, compositions and methods
YU42397A (en) * 1996-10-30 2000-10-30 Eli Lilly And Company Using raloxiphene for medicine preparation

Also Published As

Publication number Publication date
GR20050100282A (en) 2007-01-19

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Legal Events

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PG Patent granted
ML Lapse due to non-payment of fees

Effective date: 20150105