GB901312A - Pyridylcarbamyl lower alkane derivatives and processes for preparing them - Google Patents
Pyridylcarbamyl lower alkane derivatives and processes for preparing themInfo
- Publication number
- GB901312A GB901312A GB2554259A GB2554259A GB901312A GB 901312 A GB901312 A GB 901312A GB 2554259 A GB2554259 A GB 2554259A GB 2554259 A GB2554259 A GB 2554259A GB 901312 A GB901312 A GB 901312A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atom
- carbamoyl
- substituted
- carbamoyloxy
- nitrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001335 aliphatic alkanes Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- SEZWJRWTCIPRSV-UHFFFAOYSA-N [N]C(N)=O Chemical group [N]C(N)=O SEZWJRWTCIPRSV-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- -1 lower-alkanoyloxy Chemical group 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000003927 aminopyridines Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises mono-N-substituted-carbamoyl-lower-alkanes having a hydroxy, lower-alkanoyloxy, carbamoyloxy or N-mono- or di-lower-alkyl-carbamoyloxy group attached to a carbon atom of the alkane chain, which carbon atom is separated from the carbamoyl nitrogen atom by at least the carbonyl group and carries also at least one monocarbocyclic group, optionally substituted by halogens or lower alkyl or alkoxy groups, the N-substituent being a pyridyl residue joined to the carbamoyl nitrogen atom through a carbon atom of the pyridine ring, which may carry one or more simple substituents not adversely affecting the pharmacological properties of the compound (e.g. halogen, methyl, methoxy, nitro or trifluoromethyl), and the term "lower" denoting the presence of not more than 4 carbon atoms, and their acid addition and quaternary ammonium salts, and the preparation thereof by reacting an appropriate aminopyridine with an appropriately substituted lower alkanoic acid or a lower alkyl ester or acid chloride thereof. The products possess analgesic and central nervous system depressant properties. Specification 901,311 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77173758A | 1958-11-04 | 1958-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB901312A true GB901312A (en) | 1962-07-18 |
Family
ID=25092813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2554259A Expired GB901312A (en) | 1958-11-04 | 1959-07-24 | Pyridylcarbamyl lower alkane derivatives and processes for preparing them |
Country Status (2)
| Country | Link |
|---|---|
| CH (1) | CH391701A (en) |
| GB (1) | GB901312A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2597865A1 (en) * | 1986-04-29 | 1987-10-30 | Roussel Uclaf | New derivatives of a benzylalkylcarboxylic acid substituted with a 4-pyridylaminocarbonyl radical, process for their preparation, the new intermediates obtained, their application as medicaments and the pharmaceutical compositions which contain them |
| US5583147A (en) * | 1994-03-23 | 1996-12-10 | The Dupont Merck Pharmaceutical Company | Amides for the treatment of atherosclerosis |
-
1959
- 1959-07-24 GB GB2554259A patent/GB901312A/en not_active Expired
- 1959-08-13 CH CH7694359A patent/CH391701A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2597865A1 (en) * | 1986-04-29 | 1987-10-30 | Roussel Uclaf | New derivatives of a benzylalkylcarboxylic acid substituted with a 4-pyridylaminocarbonyl radical, process for their preparation, the new intermediates obtained, their application as medicaments and the pharmaceutical compositions which contain them |
| US5583147A (en) * | 1994-03-23 | 1996-12-10 | The Dupont Merck Pharmaceutical Company | Amides for the treatment of atherosclerosis |
Also Published As
| Publication number | Publication date |
|---|---|
| CH391701A (en) | 1965-05-15 |
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