[go: up one dir, main page]

GB851287A - 5-chlorotoluene-2:4-disulphonamide and alkali metal salts thereof - Google Patents

5-chlorotoluene-2:4-disulphonamide and alkali metal salts thereof

Info

Publication number
GB851287A
GB851287A GB22148/58A GB2214858A GB851287A GB 851287 A GB851287 A GB 851287A GB 22148/58 A GB22148/58 A GB 22148/58A GB 2214858 A GB2214858 A GB 2214858A GB 851287 A GB851287 A GB 851287A
Authority
GB
United Kingdom
Prior art keywords
alkali metal
disulphonamide
chloro
toluene
metal salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22148/58A
Inventor
Oliver Stephenson
Vladimir Petrow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BDH Chemicals Ltd
Original Assignee
BDH Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BDH Chemicals Ltd filed Critical BDH Chemicals Ltd
Priority to GB22148/58A priority Critical patent/GB851287A/en
Priority to FR837316A priority patent/FR531M/fr
Publication of GB851287A publication Critical patent/GB851287A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises 5-chloro-toluene-2,4-disulphonamide and alkali metal salts thereof, the preparation thereof by reacting 5-chloro-toluene-2,4-disulphonchloride with ammonia or its chemical equivalents and if desired reacting the resulting sulphonamide with an alkali metal hydroxide, and pharmaceutical preparations containing the products (see Group VI). The products have diuretic and/or natriuretic properties. 5-Chloro-toluene-2,4-disulphonchloride is prepared by reacting m-chlorotoluene with chlorosulphonic acid.ALSO:Pharmaceutical compositions comprise 5-chloro-toluene-2,4-disulphonamide or alkali metal salts thereof with pharmaceutical diluents. Preparations may be in the form of tablets and solutions.
GB22148/58A 1958-07-10 1958-07-10 5-chlorotoluene-2:4-disulphonamide and alkali metal salts thereof Expired GB851287A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB22148/58A GB851287A (en) 1958-07-10 1958-07-10 5-chlorotoluene-2:4-disulphonamide and alkali metal salts thereof
FR837316A FR531M (en) 1958-07-10 1960-08-31

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB22148/58A GB851287A (en) 1958-07-10 1958-07-10 5-chlorotoluene-2:4-disulphonamide and alkali metal salts thereof

Publications (1)

Publication Number Publication Date
GB851287A true GB851287A (en) 1960-10-12

Family

ID=10174686

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22148/58A Expired GB851287A (en) 1958-07-10 1958-07-10 5-chlorotoluene-2:4-disulphonamide and alkali metal salts thereof

Country Status (2)

Country Link
FR (1) FR531M (en)
GB (1) GB851287A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1174286B (en) * 1960-11-18 1964-07-23 Kyowa Hakko Kogyo Kk Process for the biotechnological production of 1-isoleucine
EP0033042A1 (en) * 1980-01-28 1981-08-05 Merck & Co. Inc. Ophthalmic inserts for lowering intraocular pressure comprising carbonic anhydrase inhibitors
EP0036351A3 (en) * 1980-03-04 1981-11-04 Merck & Co. Inc. Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
US6878703B2 (en) 2000-11-21 2005-04-12 Sankyo Company, Limited Pharmaceutical composition
WO2007062314A2 (en) 2005-11-23 2007-05-31 Bristol-Myers Squibb Company Heterocyclic cetp inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
EP2392567A1 (en) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Benzothiazine derivatives and their use as lxr modulators
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2015012205A1 (en) 2013-07-23 2015-01-29 第一三共株式会社 Medicine for preventing or treating hypertension
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1174286B (en) * 1960-11-18 1964-07-23 Kyowa Hakko Kogyo Kk Process for the biotechnological production of 1-isoleucine
EP0033042A1 (en) * 1980-01-28 1981-08-05 Merck & Co. Inc. Ophthalmic inserts for lowering intraocular pressure comprising carbonic anhydrase inhibitors
EP0036351A3 (en) * 1980-03-04 1981-11-04 Merck & Co. Inc. Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure
US6878703B2 (en) 2000-11-21 2005-04-12 Sankyo Company, Limited Pharmaceutical composition
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
EP2392567A1 (en) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Benzothiazine derivatives and their use as lxr modulators
WO2007062314A2 (en) 2005-11-23 2007-05-31 Bristol-Myers Squibb Company Heterocyclic cetp inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2015012205A1 (en) 2013-07-23 2015-01-29 第一三共株式会社 Medicine for preventing or treating hypertension
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof
EP4470609A2 (en) 2019-01-18 2024-12-04 Astrazeneca AB Pcsk9 inhibitors and methods of use thereof

Also Published As

Publication number Publication date
FR531M (en) 1961-05-23

Similar Documents

Publication Publication Date Title
GB851287A (en) 5-chlorotoluene-2:4-disulphonamide and alkali metal salts thereof
GB1252719A (en)
GB1212943A (en) 0,1,1,3,3-pentafluoro-2-propyl p-toluenesulphonate
GB1361779A (en) Vincamine salt and its use as a pharmaceutical composition
GB1448295A (en) Thiosemicarbazones
GB1173704A (en) Process for the Preparation of Naphthalene-1,4-Dicarboxylic Acid
GB933141A (en) Dextromethorphan n-cyclohexylsulphamate
GB870576A (en) Amino-trifluoro-toluene-disulfonyl compounds and the production thereof
GB896137A (en) 4-chloro-3-sulphamyl benzoic acid and alkali metal salts thereof and process for their preparation
GB1263677A (en) Process for the preparation of quinoxaline-di-n-oxide-aldehyde
GB867073A (en) Process for the manufacture of 6-chloro-7-sulphamyl-3:4-dihydro-1:2:3-benzothiadiazine-1:1-dioxide and its salts
GB771869A (en) Improvements in or relating to a new salt of vitamin b
JPS5414931A (en) Preparation of n-benzylglycine
GB874246A (en) Chloral derivative
GB1419433A (en) Alkali metal sulphinates
GB937598A (en) Process for the production of reserpic acid diesters
CA467502A (en) Sulpho amides of cis-endomethylene-3,6-.delta.4-tetrahydrophthalic acid
GB1204456A (en) Preparation of hydroxy-capronitrile
GB720297A (en) Improvements in or relating to the fabrication of drawn tin plated articles
CA531788A (en) Articles containing a metal salt of 2,2'-dihydroxy 5,5'-dichlorodiphenyl methane
GB1154066A (en) Process for preparing 1-Amino-3-Carboxy-Propane-2-Sulfonic Acid
CA594033A (en) Alkali metal triphosphates, alkali metal pyrophosphates and mixtures thereof and a process of preparing same
GB1318340A (en) Bicyclic compounds and a process for the manufacture thereof
GB873415A (en) Improvements in and relating to the preparation of sobrerol
CA531922A (en) 21-alkoxyoxalyl-11-hydroxyprogesterone alkali enolates