GB810917A - Salts of oestrone sulphate and the manufacture thereof - Google Patents
Salts of oestrone sulphate and the manufacture thereofInfo
- Publication number
- GB810917A GB810917A GB27683/57A GB2768357A GB810917A GB 810917 A GB810917 A GB 810917A GB 27683/57 A GB27683/57 A GB 27683/57A GB 2768357 A GB2768357 A GB 2768357A GB 810917 A GB810917 A GB 810917A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxyethyl
- methyl
- oestrone sulphate
- salts
- alkyl radicals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JKKFKPJIXZFSSB-CBZIJGRNSA-M estrone 3-sulfate(1-) Chemical class [O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-M 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- -1 quaternary ammonium oestrone sulphate salts Chemical class 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- VAJZCFLYJRMBFN-UHFFFAOYSA-N 4,4-dimethylmorpholin-4-ium Chemical compound C[N+]1(C)CCOCC1 VAJZCFLYJRMBFN-UHFFFAOYSA-N 0.000 abstract 1
- PQBAWAQIRZIWIV-UHFFFAOYSA-N N-methylpyridinium Chemical compound C[N+]1=CC=CC=C1 PQBAWAQIRZIWIV-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises quaternary ammonium oestrone sulphate salts in which alkyl radicals are attached to the quaternary nitrogen atom, or one or two alkyl radicals and a radical which together with the quaternary nitrogen atom forms a heterocyclic ring are attached to the quaternary nitrogen atom, and the preparation thereof by reacting oestrone sulphate with the required quaternary ammonium base. The heterocyclic ring, as specified, may include at least one further hetero atom such as nitrogen, or oxygen, and the alkyl radicals may contain a hydroxyl substituent. In the examples, the following compounds are prepared: the N-(b -hydroxyethyl)-N-methyl morpholinium, N,N - dimethyl - morpholinium, tetramethyl - ammonium, N - methyl - pyridinium, N - b - hydroxyethyl - N - methyl - piperidinium, and N - b - hydroxyethyl - N - methyl-pyrrolidinium salts of oestrone sulphate. The b -hydroxyethyl-trimethyl-ammonium salt of oestrone sulphate is also referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE810917X | 1956-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB810917A true GB810917A (en) | 1959-03-25 |
Family
ID=6726190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27683/57A Expired GB810917A (en) | 1956-11-14 | 1957-09-02 | Salts of oestrone sulphate and the manufacture thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB810917A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4021458A (en) * | 1974-04-18 | 1977-05-03 | Schering Aktiengesellschaft | Process for the preparation of 3-hemisulfate-17α-hydroxy steroids |
-
1957
- 1957-09-02 GB GB27683/57A patent/GB810917A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4021458A (en) * | 1974-04-18 | 1977-05-03 | Schering Aktiengesellschaft | Process for the preparation of 3-hemisulfate-17α-hydroxy steroids |
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