GB815833A - Phenanthridine compounds - Google Patents

Abstract

The invention comprises compounds of general formula <FORM:0815833/IV (b)/1> (wherein R2 is an m-nitrophenyl or m-aminophenyl radical, R2, R3, R4 are alkyl groups which may be the same or different, and X is an anion), and the preparation thereof by condensing a phenanthridine of general formula <FORM:0815833/IV (b)/2> (wherein Y is an anion which may be the same as X) with a halopyrimidine of general formula <FORM:0815833/IV (b)/3> (wherein A is a halogen atom and Z an anion which may be the same as X), and if Y and Z are not identical with X they may be converted into X after the condensation. If in the starting material R2 is a m-nitrophenyl radical, the initial condensation product may be reduced to convert the m-nitrophenyl radical into a m-aminophenyl radical. The products are trypanocidal agents with prophylactic properties. In examples: (1) 2 : 7-diamino-9-m-nitrophenyl-10 - methyl - phenanthridinium chloride is treated with 2-amino-4-chloro-1 : 6-dimethyl pyrimidinium iodide followed by silver chloride, then ammonium chloride, to give 2-amino-7-(21 - amino - 61 - methyl - 41 - pyrimidylamino)-9 - m - nitrophenylphenanthridinium 10 : 11 - dimethochloride; (2) the above compound after reduction and treatment with ammonium bromide gives 2-amino-7-(21-amino-61-methyl-41-pyrimidylamino) - 9 - m - aminophenylphenanthridinium 10 : 11 - dimethobromide. Similarly prepared are: 2 - amino - 7 -(21 - amino-61-methyl - 41 - pyrimidylamino) - 9 - m - nitrophenylphenanthridine - 10 - ethochloride - 11-methochloride, and 2 - amino - 7 - (21 - amino-61 - methyl - 41 - pyrimidylamino) - 9 - m-aminophenylphenanthridine - 10 - ethobromide-11-methobromide. In Example (5) the product of (2) is made by reacting 2 : 7-diamino-9-m-aminophenyl - 10 - methylphenanthridinium bromide with 2 - amino - 4 - chloro - 1 : 6 - dimethylpyrimidinium bromide.