GB568183A - Thyroprotein composition and method of making the same - Google Patents
Thyroprotein composition and method of making the sameInfo
- Publication number
- GB568183A GB568183A GB6877/43A GB687743A GB568183A GB 568183 A GB568183 A GB 568183A GB 6877/43 A GB6877/43 A GB 6877/43A GB 687743 A GB687743 A GB 687743A GB 568183 A GB568183 A GB 568183A
- Authority
- GB
- United Kingdom
- Prior art keywords
- iodine
- meal
- solution
- protein
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 235000012054 meals Nutrition 0.000 abstract 6
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 4
- 229910052740 iodine Inorganic materials 0.000 abstract 4
- 239000011630 iodine Substances 0.000 abstract 4
- 239000007864 aqueous solution Substances 0.000 abstract 3
- 235000018102 proteins Nutrition 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 108091005979 iodinated proteins Proteins 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 235000020183 skimmed milk Nutrition 0.000 abstract 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 2
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 2
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 235000017060 Arachis glabrata Nutrition 0.000 abstract 1
- 244000105624 Arachis hypogaea Species 0.000 abstract 1
- 235000010777 Arachis hypogaea Nutrition 0.000 abstract 1
- 235000018262 Arachis monticola Nutrition 0.000 abstract 1
- 229910001369 Brass Inorganic materials 0.000 abstract 1
- 235000013162 Cocos nucifera Nutrition 0.000 abstract 1
- 244000060011 Cocos nucifera Species 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 102000006395 Globulins Human genes 0.000 abstract 1
- 108010044091 Globulins Proteins 0.000 abstract 1
- 108010068370 Glutens Proteins 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- DKNPRRRKHAEUMW-UHFFFAOYSA-N Iodine aqueous Chemical compound [K+].I[I-]I DKNPRRRKHAEUMW-UHFFFAOYSA-N 0.000 abstract 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 abstract 1
- 235000005811 Viola adunca Nutrition 0.000 abstract 1
- 240000009038 Viola odorata Species 0.000 abstract 1
- 235000013487 Viola odorata Nutrition 0.000 abstract 1
- 235000002254 Viola papilionacea Nutrition 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 abstract 1
- 239000010951 brass Substances 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000005018 casein Substances 0.000 abstract 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
- 235000021240 caseins Nutrition 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 235000021312 gluten Nutrition 0.000 abstract 1
- 230000026045 iodination Effects 0.000 abstract 1
- 238000006192 iodination reaction Methods 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 235000013372 meat Nutrition 0.000 abstract 1
- 235000020232 peanut Nutrition 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000011135 tin Substances 0.000 abstract 1
- 229910052718 tin Inorganic materials 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
Abstract
A synthetic thyroprotein is prepared by treating a protein containing tyrosine with iodine until the million test becomes negative or the biuret test yields a blue or blue-violet colour and then maintaining the iodinated protein at a temperature which is higher than that at which the iodination was effected and is also between 50-100 DEG C. for 12-24 hours. The treatment of the protein with iodine should be carried out at 30-45 DEG C., preferably 37-40 DEG C., and in the presence of a metal such as copper, tin, zinc or brass, as catalyst. Proteins which may be used include skim milk, casein, albumen, blood serum, albumin, globulin, egg albumen, meat meal, cottonseed meal, gluten meal, soyabean meal, peanut meal, cocoanut meal. Instead of iodine, a mixture of iodine and potassium iodide in aqueous solution. In examples: (1) pulverized iodine is added to an aqueous solution containing tyrosine at pH 6-8 at 30-45 DEG C., with sodium bicarbonate in the solution as a buffer. The solution is then incubated at 50-100 DEG C. for 12-18 hours in the presence of a metal rod as catalyst; (2) powdered iodine is added to an aqueous solution of skim milk in the presence of sodium bicarbonate at 38-40 DEG C. The solution was then incubated at 38 DEG C. for 18-20 hours. Dilute hydrochloric acid was added to adjust pH to 3.8-4.0 and the precipitated iodinated protein washed with water at pH 4.0. Specification 492,265 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US568183XA | 1942-04-30 | 1942-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB568183A true GB568183A (en) | 1945-03-22 |
Family
ID=22006740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6877/43A Expired GB568183A (en) | 1942-04-30 | 1943-04-30 | Thyroprotein composition and method of making the same |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB568183A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998043013A1 (en) * | 1997-03-21 | 1998-10-01 | Dynamit Nobel Gmbh Explosivstoff- Und Systemtechnik | Compressed-gas vessel |
| EP1393636A4 (en) * | 2001-05-14 | 2004-10-27 | Vasily Petrovich Andreichuk | Biologically active food additive and biologically active forage additive for preventing iodine deficiency and optimising iodine metabolism, food and forage products containing said additives |
| US8415299B2 (en) | 2004-07-07 | 2013-04-09 | Danny Michael Hooge | Methods for improved avian performance |
-
1943
- 1943-04-30 GB GB6877/43A patent/GB568183A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998043013A1 (en) * | 1997-03-21 | 1998-10-01 | Dynamit Nobel Gmbh Explosivstoff- Und Systemtechnik | Compressed-gas vessel |
| EP1393636A4 (en) * | 2001-05-14 | 2004-10-27 | Vasily Petrovich Andreichuk | Biologically active food additive and biologically active forage additive for preventing iodine deficiency and optimising iodine metabolism, food and forage products containing said additives |
| US8415299B2 (en) | 2004-07-07 | 2013-04-09 | Danny Michael Hooge | Methods for improved avian performance |
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