GB526951A - Improvements in or relating to the preparation of cholesterol from materials containing same - Google Patents
Improvements in or relating to the preparation of cholesterol from materials containing sameInfo
- Publication number
- GB526951A GB526951A GB8989/39A GB898939A GB526951A GB 526951 A GB526951 A GB 526951A GB 8989/39 A GB8989/39 A GB 8989/39A GB 898939 A GB898939 A GB 898939A GB 526951 A GB526951 A GB 526951A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cholesterol
- extracted
- spinal cord
- preferred
- saponifying agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 8
- 235000012000 cholesterol Nutrition 0.000 title abstract 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 210000000278 spinal cord Anatomy 0.000 abstract 3
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical group [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 2
- 239000000920 calcium hydroxide Substances 0.000 abstract 2
- 235000011116 calcium hydroxide Nutrition 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical class C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 abstract 1
- 229910000287 alkaline earth metal oxide Inorganic materials 0.000 abstract 1
- 235000015278 beef Nutrition 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000008280 chlorinated hydrocarbons Chemical group 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 150000004679 hydroxides Chemical class 0.000 abstract 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000395 magnesium oxide Substances 0.000 abstract 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000003208 petroleum Substances 0.000 abstract 1
- 238000007127 saponification reaction Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- UUCCCPNEFXQJEL-UHFFFAOYSA-L strontium dihydroxide Chemical compound [OH-].[OH-].[Sr+2] UUCCCPNEFXQJEL-UHFFFAOYSA-L 0.000 abstract 1
- 229910001866 strontium hydroxide Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
526,951. Cholesterol. ARMOUR & CO. March 21, 1939, No. 8989. Convention date, May 3, 1938. [Class 2 (iii)] Cholesterol is extracted from fatty animal tissue by reacting either in solution or in the dry state the animal tissue with an alkaline saponifying agent chosen from the group consisting of the alkaline earth metal oxides and hydroxides at a temperature above 100‹C. and extracting the reaction mixture with an organic solvent for the cholesterol. The preferred saponifying agent is calcium hydroxide, and the preferred solvent is a chlorinated hydrocarbon such as ethylene dichloride. Other solvents mentioned include ether, alcohol, acetone, petroleum ether, chlorinated benzol and ethyl acetate. It is preferred to use the saponifying agent in a substantially dry condition. In examples (1) minced beef spinal cord is mixed with slaked lime and heated in an autoclave for three hours at 100‹-125‹C. The reaction mixture is then extracted with ethylene dichloride. The extract is cooled, filtered, and evaporated. (2) A mixture of spinal cord and strontium hydroxide is heated for three hours in an autoclave at 15 lb. steam pressure. Water is removed by filtration and the solid residue is extracted with ethyl acetate. (3) Spinal cord is mixed with magnesium oxide and after saponification and removal of water, the reaction product is extracted with orthodichlorbenzene.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US526951XA | 1938-05-03 | 1938-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB526951A true GB526951A (en) | 1940-09-30 |
Family
ID=21979299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8989/39A Expired GB526951A (en) | 1938-05-03 | 1939-03-21 | Improvements in or relating to the preparation of cholesterol from materials containing same |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB526951A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2640823A (en) * | 1946-06-04 | 1953-06-02 | Pittsburgh Plate Glass Co | Treatment of tall oil |
| WO2016096988A1 (en) * | 2014-12-19 | 2016-06-23 | Dsm Ip Assets B.V. | Method of extracting cholesterol from milk fat |
| WO2016096989A1 (en) * | 2014-12-19 | 2016-06-23 | Dsm Ip Assets B.V. | Method of extracting cholesterol from fish oil residue |
| US10196583B1 (en) | 2018-02-14 | 2019-02-05 | Alejandro Markovits Rojas | Fish oil cholesterol |
-
1939
- 1939-03-21 GB GB8989/39A patent/GB526951A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2640823A (en) * | 1946-06-04 | 1953-06-02 | Pittsburgh Plate Glass Co | Treatment of tall oil |
| WO2016096988A1 (en) * | 2014-12-19 | 2016-06-23 | Dsm Ip Assets B.V. | Method of extracting cholesterol from milk fat |
| WO2016096989A1 (en) * | 2014-12-19 | 2016-06-23 | Dsm Ip Assets B.V. | Method of extracting cholesterol from fish oil residue |
| US10196583B1 (en) | 2018-02-14 | 2019-02-05 | Alejandro Markovits Rojas | Fish oil cholesterol |
| EP3666867A1 (en) | 2018-02-14 | 2020-06-17 | Alejandro Markovits Rojas | Fish oil cholesterol |
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