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GB2270079A - CNS Cell differentiation factor,its preparation and use - Google Patents

CNS Cell differentiation factor,its preparation and use

Info

Publication number
GB2270079A
GB2270079A GB9319611A GB9319611A GB2270079A GB 2270079 A GB2270079 A GB 2270079A GB 9319611 A GB9319611 A GB 9319611A GB 9319611 A GB9319611 A GB 9319611A GB 2270079 A GB2270079 A GB 2270079A
Authority
GB
United Kingdom
Prior art keywords
factor
preparation
new
cell differentiation
differentiation factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9319611A
Other versions
GB9319611D0 (en
Inventor
Mark David Noble
Heidi Hoffmann
Paul Stroobant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Cancer Research
Original Assignee
Ludwig Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919106103A external-priority patent/GB9106103D0/en
Application filed by Ludwig Cancer Research filed Critical Ludwig Cancer Research
Priority to GB9319611A priority Critical patent/GB2270079A/en
Publication of GB9319611D0 publication Critical patent/GB9319611D0/en
Publication of GB2270079A publication Critical patent/GB2270079A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides a new differentiation-promoting factor of molecular weight 20-25 kilodaltons when isolated by SDS-PAGE. The factor causes O-2A progenitor cells to differentiate expressing GFAP. The new factor is a secreted protein. The invention provides therapeutic formulations comprising the new factor, and the use of the factor and those formulations in treating conditions which involve a factor-sensitive or factor-responsive cell type.
GB9319611A 1991-03-22 1993-09-22 CNS Cell differentiation factor,its preparation and use Withdrawn GB2270079A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9319611A GB2270079A (en) 1991-03-22 1993-09-22 CNS Cell differentiation factor,its preparation and use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919106103A GB9106103D0 (en) 1991-03-22 1991-03-22 Cns cell differentiation factor,its preparation and use
PCT/GB1992/000500 WO1992016560A1 (en) 1991-03-22 1992-03-20 Cns cell differentiation factor, its preparation and use
GB9319611A GB2270079A (en) 1991-03-22 1993-09-22 CNS Cell differentiation factor,its preparation and use

Publications (2)

Publication Number Publication Date
GB9319611D0 GB9319611D0 (en) 1994-01-05
GB2270079A true GB2270079A (en) 1994-03-02

Family

ID=26298622

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9319611A Withdrawn GB2270079A (en) 1991-03-22 1993-09-22 CNS Cell differentiation factor,its preparation and use

Country Status (1)

Country Link
GB (1) GB2270079A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002003A1 (en) * 1989-08-04 1991-02-21 Board Of Regents, The University Of Texas System Methods and compositions; purified preparation of neural progenitor regulatory factor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002003A1 (en) * 1989-08-04 1991-02-21 Board Of Regents, The University Of Texas System Methods and compositions; purified preparation of neural progenitor regulatory factor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Nature,vol.335,1 September 1988, pages 70-73 *
Proc Natl. Acad. Sci. USA, vol.84, February 1987, pages 842-846 *
Proc. Natl.Acad. Sci.USA,Vol.87,August 1990,pages 6368-6372 *

Also Published As

Publication number Publication date
GB9319611D0 (en) 1994-01-05

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)