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GB202006462D0 - Modifying genomes with integrase - Google Patents

Modifying genomes with integrase

Info

Publication number
GB202006462D0
GB202006462D0 GBGB2006462.2A GB202006462A GB202006462D0 GB 202006462 D0 GB202006462 D0 GB 202006462D0 GB 202006462 A GB202006462 A GB 202006462A GB 202006462 D0 GB202006462 D0 GB 202006462D0
Authority
GB
United Kingdom
Prior art keywords
integrase
modifying genomes
genomes
modifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB2006462.2A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mote Res Ltd
Original Assignee
Mote Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mote Res Ltd filed Critical Mote Res Ltd
Priority to GBGB2006462.2A priority Critical patent/GB202006462D0/en
Publication of GB202006462D0 publication Critical patent/GB202006462D0/en
Priority to PCT/GB2021/051068 priority patent/WO2021220020A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
GBGB2006462.2A 2020-05-01 2020-05-04 Modifying genomes with integrase Ceased GB202006462D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB2006462.2A GB202006462D0 (en) 2020-05-04 2020-05-04 Modifying genomes with integrase
PCT/GB2021/051068 WO2021220020A1 (en) 2020-05-01 2021-05-04 Modifying genomes with integrase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2006462.2A GB202006462D0 (en) 2020-05-04 2020-05-04 Modifying genomes with integrase

Publications (1)

Publication Number Publication Date
GB202006462D0 true GB202006462D0 (en) 2020-06-17

Family

ID=71080541

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB2006462.2A Ceased GB202006462D0 (en) 2020-05-01 2020-05-04 Modifying genomes with integrase

Country Status (2)

Country Link
GB (1) GB202006462D0 (en)
WO (1) WO2021220020A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
CN114127285B (en) 2019-03-19 2024-09-10 布罗德研究所股份有限公司 Methods and compositions for editing nucleotide sequences
EP3956349A1 (en) 2019-04-17 2022-02-23 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA
EP4469569A1 (en) * 2022-01-28 2024-12-04 Sangamo Therapeutics, Inc. Serine recombinase systems for site-specific gene editing
EP4587560A1 (en) * 2022-09-16 2025-07-23 Beam Therapeutics Inc. Large serine recombinases, systems and uses thereof
CN116004586B (en) * 2022-12-01 2025-08-26 上海药明生物医药有限公司 Method for improving the recombination efficiency of Bxb1 enzyme by optimization
EP4662306A2 (en) * 2023-02-09 2025-12-17 The Broad Institute Inc. Evolved recombinases for editing a genome in combination with prime editing
WO2025006468A2 (en) 2023-06-26 2025-01-02 University Of Hawaii Evolved integrases and methods of using the same for genome editing
WO2025193915A1 (en) * 2024-03-14 2025-09-18 Massachusetts Institute Of Technology High efficiency integrases for gene editing

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
DE60143564D1 (en) * 2000-02-18 2011-01-13 Univ R MODIFIED RECOMBINAS TO MODIFY THE GENOM
AU2005240091B2 (en) * 2004-04-30 2011-12-15 Poetic Genetics, Llc Hybrid recombinases for genome manipulation
WO2010028245A2 (en) * 2008-09-08 2010-03-11 Poetic Genetics, Llc. Altered phic31 integrases having improved efficiency and specificity and methods of using same
WO2012075462A2 (en) * 2010-12-03 2012-06-07 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treatment of muscular dystrophy
CA3031670A1 (en) * 2016-07-26 2018-02-01 Senti Biosciences, Inc. Spatiotemporal regulators

Also Published As

Publication number Publication date
WO2021220020A1 (en) 2021-11-04

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)