GB2018751A - Tetrahydroalstonine derivatives - Google Patents
Tetrahydroalstonine derivativesInfo
- Publication number
- GB2018751A GB2018751A GB7912932A GB7912932A GB2018751A GB 2018751 A GB2018751 A GB 2018751A GB 7912932 A GB7912932 A GB 7912932A GB 7912932 A GB7912932 A GB 7912932A GB 2018751 A GB2018751 A GB 2018751A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radical
- alkoxy
- dialkylamino
- alkyl
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- GRTOGORTSDXSFK-DLLGKBFGSA-N tetrahydroalstonine Chemical class C1=CC=C2C(CCN3C[C@H]4[C@H](C)OC=C([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 GRTOGORTSDXSFK-DLLGKBFGSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010002660 Anoxia Diseases 0.000 abstract 1
- 208000018152 Cerebral disease Diseases 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- -1 piperidino, morpholino, piperazino Chemical group 0.000 abstract 1
- 230000000506 psychotropic effect Effects 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compounds corresponding to the formula <IMAGE> in which R1 is hydrogen or a hydroxyalkyl, alkyl or alkoxycarbonyl radical and R2 is either a hydroxyl radical, or a linear or branched alkoxy radical which can carry halogens as substituents, or a (cycloalkyl)-alkoxy radical, or a cycloalkoxy radical, or an alkoxy radical carrying a piperidino, morpholino, piperazino or pyrrolidino group, or a (dialkylamino)- alkoxy radical, or an amino radical, or an alkylamino radical, or a dialkylamino radical, or a cycloalkylamino radical or a radical OMe (Me = alkali metal or alkaline earth metal), except for the compound wherein R1 is H and R2 is CH3O, the alkyl and alkoxy radicals having from 1 to 6 carbon atoms and the cyloalkyl and cycloalkoxy radicals having from 3 to 6 carbon atoms, and also their addition salts with pharmaceutically acceptable acids, have anti-anoxia and psychotropic activity and are useful in treating cerebral disorders.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7811026A FR2422664A1 (en) | 1978-04-14 | 1978-04-14 | Tetra:hydro:alstonine ester and amide derivs. - with anti:anoxic, psychotropic and antidepressant activity (BE 15.10.79) |
| FR7906055A FR2450835A2 (en) | 1978-04-14 | 1979-03-09 | TETRAHYDROALSTONIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB2018751A true GB2018751A (en) | 1979-10-24 |
Family
ID=26220552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7912932A Withdrawn GB2018751A (en) | 1978-04-14 | 1979-04-12 | Tetrahydroalstonine derivatives |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS54145700A (en) |
| DE (1) | DE2914805A1 (en) |
| DK (1) | DK149279A (en) |
| ES (1) | ES479540A1 (en) |
| FI (1) | FI791194A7 (en) |
| FR (1) | FR2450835A2 (en) |
| GB (1) | GB2018751A (en) |
| GR (1) | GR66991B (en) |
| IL (1) | IL57061A0 (en) |
| IT (1) | IT1111923B (en) |
| LU (1) | LU81145A1 (en) |
| NL (1) | NL7902958A (en) |
| NO (1) | NO791222L (en) |
| PT (1) | PT69487A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0017525A1 (en) * | 1979-03-14 | 1980-10-15 | Pierre Fabre S.A. | Derivatives of tetrahydroalstonine, their preparation and their application as medicaments |
| EP0032889B1 (en) * | 1980-01-09 | 1984-02-15 | OMNICHEM Société anonyme | 1,10-dimethyl-oxayohimbane derivatives and medicaments containing them |
| FR2539416A1 (en) * | 1983-01-14 | 1984-07-20 | Adir | New oxindole derivatives, process for their preparation and the pharmaceutical compositions containing them |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE501156C2 (en) * | 1993-04-21 | 1994-11-28 | Ellemtel Utvecklings Ab | Reference signal composed of clock signal and synchronization signal, synchronization device and method, etc. reference signal |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1225652B (en) * | 1961-08-01 | 1966-09-29 | Boehringer & Soehne Gmbh | Process for the preparation of 3, 4, 5, 6-tetrahydroserpentine derivatives substituted in the 1-position and their salts |
-
1979
- 1979-03-09 FR FR7906055A patent/FR2450835A2/en active Granted
- 1979-04-10 DK DK149279A patent/DK149279A/en not_active IP Right Cessation
- 1979-04-10 NO NO79791222A patent/NO791222L/en unknown
- 1979-04-11 DE DE19792914805 patent/DE2914805A1/en not_active Withdrawn
- 1979-04-11 FI FI791194A patent/FI791194A7/en not_active Application Discontinuation
- 1979-04-11 IL IL57061A patent/IL57061A0/en unknown
- 1979-04-11 IT IT21793/79A patent/IT1111923B/en active
- 1979-04-11 ES ES479540A patent/ES479540A1/en not_active Expired
- 1979-04-12 NL NL7902958A patent/NL7902958A/en not_active Application Discontinuation
- 1979-04-12 GB GB7912932A patent/GB2018751A/en not_active Withdrawn
- 1979-04-12 LU LU81145A patent/LU81145A1/en unknown
- 1979-04-12 GR GR58869A patent/GR66991B/el unknown
- 1979-04-12 PT PT69487A patent/PT69487A/en unknown
- 1979-04-13 JP JP4595879A patent/JPS54145700A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0017525A1 (en) * | 1979-03-14 | 1980-10-15 | Pierre Fabre S.A. | Derivatives of tetrahydroalstonine, their preparation and their application as medicaments |
| EP0032889B1 (en) * | 1980-01-09 | 1984-02-15 | OMNICHEM Société anonyme | 1,10-dimethyl-oxayohimbane derivatives and medicaments containing them |
| FR2539416A1 (en) * | 1983-01-14 | 1984-07-20 | Adir | New oxindole derivatives, process for their preparation and the pharmaceutical compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| FI791194A7 (en) | 1979-10-15 |
| FR2450835A2 (en) | 1980-10-03 |
| IT7921793A0 (en) | 1979-04-11 |
| NO791222L (en) | 1979-10-16 |
| NL7902958A (en) | 1979-10-16 |
| GR66991B (en) | 1981-05-18 |
| IT1111923B (en) | 1986-01-13 |
| IL57061A0 (en) | 1979-07-25 |
| DE2914805A1 (en) | 1979-10-18 |
| PT69487A (en) | 1979-05-01 |
| DK149279A (en) | 1979-10-15 |
| LU81145A1 (en) | 1980-12-16 |
| ES479540A1 (en) | 1979-07-16 |
| JPS54145700A (en) | 1979-11-14 |
| FR2450835B2 (en) | 1982-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |