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GB2020280A - 4,5-Dihydroimidazol-Z-yl Amino Substituted Isoquinolines - Google Patents

4,5-Dihydroimidazol-Z-yl Amino Substituted Isoquinolines

Info

Publication number
GB2020280A
GB2020280A GB7913821A GB7913821A GB2020280A GB 2020280 A GB2020280 A GB 2020280A GB 7913821 A GB7913821 A GB 7913821A GB 7913821 A GB7913821 A GB 7913821A GB 2020280 A GB2020280 A GB 2020280A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
radical containing
dihydroimidazol
alkyl
attached
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7913821A
Other versions
GB2020280B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7812026A external-priority patent/FR2424270A1/en
Priority claimed from FR7904004A external-priority patent/FR2449087A2/en
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Publication of GB2020280A publication Critical patent/GB2020280A/en
Application granted granted Critical
Publication of GB2020280B publication Critical patent/GB2020280B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

New isoquinoline derivatives of the general formula; <IMAGE> wherein R1 represents a hydrogen atom or a hydroxyalkyl radical containing 1 to 4 carbon atoms, the imidazolin-2-ylamino group is attached to the 4-, 5-, 6-, 7- or 8- position of the isoquinoline nucleus, and the symbols R2 and R3, which have the same or different significances, are attached to carbon atoms in the remaining positions of the isoquinoline nucleus and each represents a hydrogen or halogen atom, an alkyl radical containing 1 to 4 carbon atoms, an alkoxy radical containing 1 to 4 carbon atoms, an alkoxyalkyl group in which the alkyl and alkoxy moieties each contain 1 to 4 carbon atoms; an alkylthio radical containing 1 to 4 carbon atoms, or a dialkylamino group in which each alkyl radical contains 1 to 4 carbon atoms, are useful as anti-hypertensive agents.
GB7913821A 1978-04-24 1979-04-20 4,5-dihydroimidazol-z-yl amino substatuted isoquinolines Expired GB2020280B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7812026A FR2424270A1 (en) 1978-04-24 1978-04-24 4,5-Di:hydro-2-imidazolyl-amino-isoquinoline derivs. - useful as antihypertensives having low toxicity and free from sedative side effects
FR7904004A FR2449087A2 (en) 1979-02-16 1979-02-16 4,5-Di:hydro-2-imidazolyl-amino-isoquinoline derivs. - useful as antihypertensives having low toxicity and free from sedative side effects

Publications (2)

Publication Number Publication Date
GB2020280A true GB2020280A (en) 1979-11-14
GB2020280B GB2020280B (en) 1982-07-28

Family

ID=26220560

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7913821A Expired GB2020280B (en) 1978-04-24 1979-04-20 4,5-dihydroimidazol-z-yl amino substatuted isoquinolines

Country Status (10)

Country Link
AU (1) AU4621979A (en)
DE (1) DE2916577A1 (en)
DK (1) DK166979A (en)
ES (2) ES479878A1 (en)
GB (1) GB2020280B (en)
IT (1) IT1112581B (en)
LU (1) LU81182A1 (en)
NL (1) NL7902993A (en)
NZ (1) NZ190245A (en)
SE (1) SE7903554L (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786364A (en) * 1995-02-11 1998-07-28 Astra Aktiebolag Bicyclic isothiourea derivatives useful in therapy
US6933311B2 (en) 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
US7767705B2 (en) 2006-08-25 2010-08-03 Abbott Laboratories Compounds that inhibit TRPV1 and uses thereof
US8030504B2 (en) 2006-12-20 2011-10-04 Abbott Laboratories Antagonists of the TRPV1 receptor and uses thereof
US8232411B2 (en) 2008-03-20 2012-07-31 Abbott Laboratories Methods for making central nervous system agents that are TRPV1 antagonists

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786364A (en) * 1995-02-11 1998-07-28 Astra Aktiebolag Bicyclic isothiourea derivatives useful in therapy
US6040314A (en) * 1995-02-11 2000-03-21 Astra Ab Bicyclic isothiourea derivatives useful in therapy
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US8247413B2 (en) 2002-02-20 2012-08-21 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US6933311B2 (en) 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7767705B2 (en) 2006-08-25 2010-08-03 Abbott Laboratories Compounds that inhibit TRPV1 and uses thereof
US8815930B2 (en) 2006-08-25 2014-08-26 Abbvie Inc. Compounds that inhibit TRPV1 and uses thereof
US8030504B2 (en) 2006-12-20 2011-10-04 Abbott Laboratories Antagonists of the TRPV1 receptor and uses thereof
US8350083B2 (en) 2006-12-20 2013-01-08 Abbvie Inc. Antagonists of the TRPV1 receptor and uses thereof
US8232411B2 (en) 2008-03-20 2012-07-31 Abbott Laboratories Methods for making central nervous system agents that are TRPV1 antagonists

Also Published As

Publication number Publication date
AU4621979A (en) 1979-11-01
ES482070A1 (en) 1980-04-01
ES479878A1 (en) 1980-08-16
NL7902993A (en) 1979-10-26
LU81182A1 (en) 1979-11-07
GB2020280B (en) 1982-07-28
DE2916577A1 (en) 1979-10-31
IT7922150A0 (en) 1979-04-24
IT1112581B (en) 1986-01-20
NZ190245A (en) 1981-03-16
DK166979A (en) 1979-10-25
SE7903554L (en) 1979-10-25

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee