GB2012260A - 4-desacetoxy-4 alpha -hydroxyindole- dihydroindoles, pharmaceutical formulations containing them and their use as antimitotic agents - Google Patents
4-desacetoxy-4 alpha -hydroxyindole- dihydroindoles, pharmaceutical formulations containing them and their use as antimitotic agentsInfo
- Publication number
- GB2012260A GB2012260A GB7843032A GB7843032A GB2012260A GB 2012260 A GB2012260 A GB 2012260A GB 7843032 A GB7843032 A GB 7843032A GB 7843032 A GB7843032 A GB 7843032A GB 2012260 A GB2012260 A GB 2012260A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alpha
- antimitotic agents
- dihydroindoles
- desacetoxy
- hydroxyindole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003080 antimitotic agent Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Novel compounds of the formula <IMAGE> wherein R<2> is CH3 or CHO; when taken singly R<5> is H and one of R<3> and R<4> is OH or H and the other is C2H5, and when taken together R<4> and R<5> form an alpha - epoxide ring and R<3> is C2H5; when taken together R<6> is H and R<7> is OR' and when taken together R<6> and R<7> are oxo; R<1> is H or acetyl and R is OCH3 or NHNH2 with the proviso that if R is NHNH2, R' is H; and pharmaceutically acceptable acid addition salts thereof, which may be prepared by oxidation of the 4 beta - hydroxy compound optionally followed by modification of the oxo group formed, are useful as antimitotic agents.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/848,837 US4122082A (en) | 1977-11-07 | 1977-11-07 | 4-Desacetoxy-4-oxovinblastine |
| US05/890,422 US4195022A (en) | 1978-03-27 | 1978-03-27 | 4-Desacetoxy-4α-hydroxyvinblastine and related compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2012260A true GB2012260A (en) | 1979-07-25 |
| GB2012260B GB2012260B (en) | 1982-11-03 |
Family
ID=27126805
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8200664A Expired GB2089806B (en) | 1977-11-07 | 1978-11-02 | 4-desacetoxy-oxo-indole-dyhydroindole intermediates |
| GB7843032A Expired GB2012260B (en) | 1977-11-07 | 1978-11-02 | 4-desacetoxy 4 hydroxyindole dihydroindoles pharmaceutical formulations containing them and their use as antimitotic agents |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8200664A Expired GB2089806B (en) | 1977-11-07 | 1978-11-02 | 4-desacetoxy-oxo-indole-dyhydroindole intermediates |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5473796A (en) |
| AR (1) | AR227620A1 (en) |
| CH (1) | CH638814A5 (en) |
| DK (1) | DK147302C (en) |
| FR (1) | FR2407935A1 (en) |
| GB (2) | GB2089806B (en) |
| HU (1) | HU184623B (en) |
| IE (1) | IE47489B1 (en) |
| IL (1) | IL55865A (en) |
| IT (1) | IT1100920B (en) |
| LU (1) | LU80474A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4602909A (en) * | 1982-02-09 | 1986-07-29 | Richter Gedeon Vegyeszeti Gyar Rt | Iontophoresis intermediary material and contact solution for the treatment of chronic pain syndromes |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2894966B1 (en) * | 2005-12-20 | 2008-03-14 | Pierre Fabre Medicament Sa | NEW CRYSTALLINE FORM OF VINFLUNINE |
| USD973040S1 (en) * | 2020-11-06 | 2022-12-20 | Lite-On Electronics (Guangzhou) Limited | Antenna monitoring tool box |
-
1978
- 1978-11-02 GB GB8200664A patent/GB2089806B/en not_active Expired
- 1978-11-02 GB GB7843032A patent/GB2012260B/en not_active Expired
- 1978-11-03 AR AR274332A patent/AR227620A1/en active
- 1978-11-03 LU LU80474A patent/LU80474A1/en unknown
- 1978-11-03 IT IT29435/78A patent/IT1100920B/en active
- 1978-11-03 IL IL55865A patent/IL55865A/en unknown
- 1978-11-03 FR FR7831134A patent/FR2407935A1/en active Granted
- 1978-11-04 HU HU78EI818A patent/HU184623B/en unknown
- 1978-11-06 CH CH1141978A patent/CH638814A5/en not_active IP Right Cessation
- 1978-11-06 IE IE2189/78A patent/IE47489B1/en unknown
- 1978-11-06 DK DK494178A patent/DK147302C/en not_active IP Right Cessation
- 1978-11-07 JP JP13723678A patent/JPS5473796A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4602909A (en) * | 1982-02-09 | 1986-07-29 | Richter Gedeon Vegyeszeti Gyar Rt | Iontophoresis intermediary material and contact solution for the treatment of chronic pain syndromes |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5473796A (en) | 1979-06-13 |
| GB2012260B (en) | 1982-11-03 |
| AR227620A1 (en) | 1982-11-30 |
| HU184623B (en) | 1984-09-28 |
| FR2407935B1 (en) | 1981-06-26 |
| IT7829435A0 (en) | 1978-11-03 |
| LU80474A1 (en) | 1979-03-19 |
| IL55865A (en) | 1982-11-30 |
| GB2089806A (en) | 1982-06-30 |
| GB2089806B (en) | 1982-11-24 |
| IE782189L (en) | 1979-05-07 |
| DK147302B (en) | 1984-06-12 |
| IL55865A0 (en) | 1979-01-31 |
| FR2407935A1 (en) | 1979-06-01 |
| IE47489B1 (en) | 1984-04-04 |
| DK494178A (en) | 1979-05-08 |
| IT1100920B (en) | 1985-09-28 |
| CH638814A5 (en) | 1983-10-14 |
| DK147302C (en) | 1985-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK57184A (en) | Diphenylbutyl-piperazinecarboxamides | |
| ES8802229A1 (en) | Macrolide antibiotics and their preparation | |
| GB1544872A (en) | 4-hydroxyphenylalkanolamine derivatives and preparation thereof | |
| JPS5432460A (en) | Cycloalkylidenemethylphenylacetic acid derivative and their preparation | |
| ES2001341A6 (en) | Novel guanidinomethylbenzoic acid derivatives. | |
| GB2019844A (en) | A beta -lactam series compound | |
| SE7609495L (en) | N-TETRAHYDROFURFURYL-NOROXIMORPHONE, ITS ACID ADDITIONAL SALTS, MEDICINAL PRODUCTS CONTAINING THESE AND PROCEDURES FOR THE PREPARATION | |
| GB2012260A (en) | 4-desacetoxy-4 alpha -hydroxyindole- dihydroindoles, pharmaceutical formulations containing them and their use as antimitotic agents | |
| IE792300L (en) | 2,4, 6-triiodoisophthalamic acid derivatives; x-ray¹contrast agents | |
| ES466192A1 (en) | Isoquinoline derivatives and pharmaceutical compositions containing them | |
| IL57834A0 (en) | Substituted 2-phenylamino-2-imidazolines and salts thereof,their preparation and pharmaceutical compositions containing them | |
| IE791930L (en) | Cyclohexadienes. | |
| JPS5225740A (en) | Preparation of o-acyl-amidinophenols or acid addition salts thereof | |
| JPS53127450A (en) | 3-alkoxy-4-homoisotwistanes, their preparation and perfume compositions containing the same | |
| JPS5432471A (en) | 8-aklyl-3-oxo-2-oxabicyclo(3,2,1)-octanes, their preparation, and perfume composition containing the same | |
| FI843208A0 (en) | 7-SUBSTITUTE 3-OXO-17-PREGN-4-EN-21,17-CARBOLACTTONER, FRUIT PROCESS FOR FRAMSTAELLNING AV DEM OCH PHARMACEUTICAL PREPARATION INNEHAOLLANDE DEM. | |
| JPS5334764A (en) | Preparation of diterpene derivatives and their preparation | |
| JPS5427578A (en) | 1-carboxyalkylcarbamoyl-5-fluorouracil derivatives and their preparation | |
| JPS5414951A (en) | Preparation of vitamin d derivatives | |
| JPS53132597A (en) | Cytidylic acid derivative and its preparation | |
| JPS53101308A (en) | Derivative of 5,6-dihydro-2h-pyran and its preparation | |
| JPS53112851A (en) | Cyclpentenone derivative and its preparation | |
| JPS5416458A (en) | Preparation of oxime substituted phenylacetic acid derivatives | |
| JPS5259184A (en) | Preparation of cephalosporin derivatives | |
| JPS5344573A (en) | Optical active 2-piperidineethanols and their preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |