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GB2001631A - Physiologically-active benzofuranone derivatives - Google Patents

Physiologically-active benzofuranone derivatives

Info

Publication number
GB2001631A
GB2001631A GB787829032A GB7829032A GB2001631A GB 2001631 A GB2001631 A GB 2001631A GB 787829032 A GB787829032 A GB 787829032A GB 7829032 A GB7829032 A GB 7829032A GB 2001631 A GB2001631 A GB 2001631A
Authority
GB
United Kingdom
Prior art keywords
carboxyethoxy
hydrogen
physiologically
active
carboxymethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB787829032A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of GB2001631A publication Critical patent/GB2001631A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Medicinal 2-benzylidene-3-benzofuranones of the formula <IMAGE> in which: R1 is hydrogen, hydroxy, carboxymethoxy, 2-carboxyethoxy or nitro; R2 is hydrogen, hydroxy, carboxymethoxy, 2-carboxyethoxy, nitro or carboxy; R3 is hydrogen, hydroxy, carboxymethoxy, 2-carboxyethoxy, 1-carboxyethoxy, nitro, carboxy, or dimethylamino; or R1 and R2 or R2 and R3 are together -CH = CH-CH = CH-, provided that R1, R2 and R3 are not simultaneously hydrogen, and their pharmaceutically acceptable salts have analgesic, anti-inflammatory and anti-pyretic activities, and activity as inhibitors of platelet aggregation.
GB787829032A 1977-07-06 1978-07-06 Physiologically-active benzofuranone derivatives Withdrawn GB2001631A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7720869A FR2396756A1 (en) 1977-07-06 1977-07-06 NEW BENZYLIDENE-2-BENZOFURANNONES-3, THEIR OBTAINING AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
GB2001631A true GB2001631A (en) 1979-02-07

Family

ID=9193073

Family Applications (1)

Application Number Title Priority Date Filing Date
GB787829032A Withdrawn GB2001631A (en) 1977-07-06 1978-07-06 Physiologically-active benzofuranone derivatives

Country Status (4)

Country Link
JP (1) JPS5444659A (en)
DE (1) DE2829619A1 (en)
FR (1) FR2396756A1 (en)
GB (1) GB2001631A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259340A (en) 1978-09-13 1981-03-31 Lilly Industries Limited Aurone derivatives
USRE32196E (en) * 1978-09-13 1986-07-01 Lilly Industries Limited Aurone derivatives
US4906636A (en) * 1985-05-08 1990-03-06 E. I. Du Pont De Nemours And Company 2-Substituted-1-naphthols as 5-lipoxygenase inhibitors
US5026759A (en) * 1985-05-08 1991-06-25 Du Pont Merck Pharmaceutical 2-substituted-1-naphthols as 5-lipoxygenase inhibitors
GB2425061A (en) * 2005-04-06 2006-10-18 Engelhard Lyon Aurone compounds having melanogenesis/depigmenting activity
CN111285829A (en) * 2018-12-07 2020-06-16 广东药科大学 PPAR gamma/delta dual agonist, preparation method thereof and application thereof as medicament

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259340A (en) 1978-09-13 1981-03-31 Lilly Industries Limited Aurone derivatives
USRE32196E (en) * 1978-09-13 1986-07-01 Lilly Industries Limited Aurone derivatives
US4906636A (en) * 1985-05-08 1990-03-06 E. I. Du Pont De Nemours And Company 2-Substituted-1-naphthols as 5-lipoxygenase inhibitors
US5026759A (en) * 1985-05-08 1991-06-25 Du Pont Merck Pharmaceutical 2-substituted-1-naphthols as 5-lipoxygenase inhibitors
GB2425061A (en) * 2005-04-06 2006-10-18 Engelhard Lyon Aurone compounds having melanogenesis/depigmenting activity
GB2425061B (en) * 2005-04-06 2008-06-25 Engelhard Lyon Use of aurones for their depigmenting activity or melanogenesis-inhibiting activity in cosmetic or dermatological compositions
CN111285829A (en) * 2018-12-07 2020-06-16 广东药科大学 PPAR gamma/delta dual agonist, preparation method thereof and application thereof as medicament
WO2021036514A1 (en) * 2018-12-07 2021-03-04 广东药科大学 PPAR γ/δ DUAL AGONIST, PREPARATION METHOD THEREOF AND USE THEREOF IN PREPARING A DRUG
CN111285829B (en) * 2018-12-07 2021-09-21 广东药科大学 PPAR gamma/delta dual agonist, preparation method thereof and application thereof as medicament

Also Published As

Publication number Publication date
JPS5444659A (en) 1979-04-09
FR2396756A1 (en) 1979-02-02
DE2829619A1 (en) 1979-01-25

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)