GB2072508A - An antifungal and antibacterial agent - Google Patents
An antifungal and antibacterial agent Download PDFInfo
- Publication number
- GB2072508A GB2072508A GB8105672A GB8105672A GB2072508A GB 2072508 A GB2072508 A GB 2072508A GB 8105672 A GB8105672 A GB 8105672A GB 8105672 A GB8105672 A GB 8105672A GB 2072508 A GB2072508 A GB 2072508A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antifungal
- antibacterial agent
- hydroxystyrene
- poly
- effective ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000843 anti-fungal effect Effects 0.000 title claims abstract description 42
- 229940121375 antifungal agent Drugs 0.000 title claims abstract description 40
- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 38
- 239000003429 antifungal agent Substances 0.000 title claims abstract description 38
- -1 poly(p-hydroxystyrene) Polymers 0.000 claims abstract description 83
- 229920000642 polymer Polymers 0.000 claims abstract description 47
- 150000003839 salts Chemical class 0.000 claims abstract description 30
- 239000004615 ingredient Substances 0.000 claims abstract description 29
- 239000001257 hydrogen Substances 0.000 claims abstract description 18
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 15
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- 229910052736 halogen Inorganic materials 0.000 claims abstract description 10
- 150000002367 halogens Chemical class 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 7
- 239000003921 oil Substances 0.000 claims abstract description 7
- 239000003973 paint Substances 0.000 claims abstract description 7
- 229910006069 SO3H Inorganic materials 0.000 claims abstract description 6
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- 125000003118 aryl group Chemical group 0.000 claims description 11
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- 230000000694 effects Effects 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- XJTQJERLRPWUGL-UHFFFAOYSA-N iodomethylbenzene Chemical compound ICC1=CC=CC=C1 XJTQJERLRPWUGL-UHFFFAOYSA-N 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000002649 leather substitute Substances 0.000 description 1
- 229920005684 linear copolymer Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229920003986 novolac Polymers 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 125000005702 oxyalkylene group Chemical group 0.000 description 1
- 229940096825 phenylmercury Drugs 0.000 description 1
- DCNLOVYDMCVNRZ-UHFFFAOYSA-N phenylmercury(.) Chemical compound [Hg]C1=CC=CC=C1 DCNLOVYDMCVNRZ-UHFFFAOYSA-N 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000007870 radical polymerization initiator Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 239000010731 rolling oil Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Inorganic materials O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 238000012719 thermal polymerization Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000003606 tin compounds Chemical class 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
An antifungal and antibacterial agent includes poly(p-hydroxystyrene), a derivative of said poly(p- hydroxystyrene), or a salt thereof as an effective ingredient. A preferred effective ingredient is a polymer having a polymeric unit represented by the formula (I> <IMAGE> wherein X and X' are each hydrogen, halogen, or -SO3H, Y is hydrogen, residue of an alcohol except for the -OH group, or residue of an organic or inorganic acid except for the -OH group, or a salt thereof. The agent may be incorporated in such materials as wood, pulp, white water from pulp-making machines, bamboo, rush, polymers, water-soluble metal working and quenching oils and water-soluble hydraulic fluid, paint, adhesive, glue, starch, sizing agents, hides, leather, food, medicine and cosmetics.
Description
SPECIFICATION
An antifungal and antibacterial agent
This invention relates to an antifungal and anti-bacterial agent.
Fungi and bacteria present particular problems in humid environments. They attack many things, such as foods, medicines, wood, pulp, bamboo, rush, polymeric chemical products (e.g., plastics), oils including water-soluble metal working oils (e.g., water soluble cutting oil and water soluble rolling oil), water soluble quenching oil, and water soluble hydraulic fluid, aqueous paints, adhesive, glue, starch, hides and leather, cosmetics and sizing agents. Historically, most fungicides and bacteriocides were made of phenyl mercury, organic tin compounds, and pentachlorophenol, but since these compounds have been found to cause severe secondary pollution, their use has been largely banned. More recently, sulfur- or nitrogen-containing compounds and heterocyclic compounds have been used, but have not been found to exhibit particularly good effects.Current criteria for bacteriocides and fungicides require that they have no toxicity and cause no secondary pollution when discharged to the environments. No product fully satisfying these criteria has been available in the market. The properties common to most commercially available fungicides and bacteriocides are that they be made of compounds of low molecular weight and that they be water-soluble, but unfortunately, such properties accentuate the problem of secondary pollution.
Some phenols of low molecular weight are known to have antibacterial effects. Compounds having a slightly higher molecular weight prepared by condensing phenols with aldehydes such as formaldehyde or ketones are also known, but their antifungal and antibacterial effects are substantially lost when more than three phenol nuclei are condensed with the aldehyde or ketone. For instance, almost no antifungal or antibacterial effect is exhibited by 1-(p-hydroxyphe nyl)-l -(o-hydroxy-m-ethylphenyl)-ethane.
An object of the present invention is therefore to provide an antifungal and antibacterial agent which alleviates or overcomes the above-mentioned problems experienced in the prior art.
Accordingly, the invention resides in an antifungal and antibacterial agent including as an effective ingredient poly(p-hydroxystyrene), a derivative of said poly(p-hydroxystyrene), or a salt thereof, each having a molecular weight of at least about 1 500.
The antifungal and antibacterial agent of this invention may comprise as an effective agent poly(p-hydroxystyrene) per se, a poly(p-hydroxystyrene) wherein the nucleus is substituted by halogen or sulfonic acid groups, or wherein the phenolic hydroxyl group of which is etherized or esterified, or salts thereof. Therefore, the anti-fungal and antibacterial agent of this invention
includes as an effective ingredient poly(p-hydroxystyrene) or a derivative of said poly(p
hydroxystyrene) which has a polymeric unit represented by formula (I)
wherein X and X' are each hydrogen, halogen or -SO3H, Y.is hydrogen, residue of an alcohol except for the -OH group or residue of an organic or inorganic acid except for the -OH group, or a salt thereof, each having a molecular weight of at least about 1 500.
The end group of the polymer used in this invention is not extremely important. The end group of the polymer varies with the polymerization reaction (radical and cation polymerizations), polymerization initiator, reaction solvent and the like. Examples of the end group of the polymer used in this invention include
CH3COO-, CH3-, (CH3) 3CO- groups, which are derived from a radical polymerization initiator (e.g., benzoyl peroxide, acetoyl peroxide, tert-butyl hydroperoxide),
groups, which are derived from p-hydroxystyrene as a monomer, a residue of a solvent except for the hydrogen atom (e.g., RO- and
groups, wherein R is hydrogen or an alkyl group having 1 to 10 carbon atoms, etc.) which is derived from a reaction solvent.
The polymer may be a homopolymer or a copolymer, which may be a linear copolymer or graft copolymer or may have a crosslinked three-dimensional network structure. The antifungal and antibacterial agent of this invention may be represented by the formula (I)
wherein X, X' and Y are the same as defined above, b is 0 or a positive number, D is a comonomer, and n is the degree of polymerization) or a salt thereof. In the formula (I'), n is more than about 1 2, preferably more than about 16. The reason b or n is not defined to be an integer is that a polymer is intrinsically a mixture and that it is better understood by defining its average structure rather than the individual constituent molecules.
The halogens X and X' in formulae (I) and (I') can include bromine, iodine, chlorine, and fluorine. Examples of Y include hydrogen; residue of an alcohol except for the -OH group such as an alkyl group, an aromatic substituted alkyl group, -(R,O)mH group, wherein R1 is an alkylene group having two or more carbon atoms, and m is an integer of at least one; and residue of an organic or inorganic acid except for the -OH group such as
group, wherein R2 is hydrogen, an alkyl group, a halogen-substituted alkyl group, an aromatic group, -(CH2)pCOOH group, wherein p is O or an integer of at least one,
groups, wherein R3 is an aromatic group.The alkyl group as Y preferably has from 1 to 9, and particularly preferably from 1 to 3, carbon atoms, and examples of the alkyl group include methyl, ethyl, propyl, butyl, pentyl, hexyl and octyl. The aromatic-substituted alkyl group as Y preferably has from 7 to 10 carbon atoms, and examples of the aromatic-substituted alkyl group include benzyl, 2-phenylethyl, and 3-phenylpropyl. The oxyalkylene group R,O preferably has from 2 to 4 carbon atoms, and examples thereof include oxyethylene, oxypropylene, and oxybutylene. The symbol m is preferably from 1 to 20, and particularly preferably from 1 to 10.
The alkyl group and halogen substituted alkyl group as R2 preferably have from 1 to 17, and particularly preferably from 1 to 4 carbon atoms, and examples of which include methyl, ethyl, propyl, trichloromethyl, monochloromethyl, butyl, pentyl, hexyl, octyl, nonyl, decyl, and dodecyl. The aromatic group as R2 preferably has from 6 to 8 carbon atoms, and examples of which are phenyl, tolyl, and xylyl. The symbol p is preferably 0 or 1 to 8, particularly preferably 0 or 1 to 4. The aromatic group as R3 preferably has from 6 to 10 carbon atoms, and examples there of include phenyl, tolyl, xylyl, propylphenyl and butylphenyl. The comonomer used for D according to formula (I') may be any compound, provided that the polymer contains at least about 30 wt% of the hydroxystyrene unit.When X and/or X' are -SO3H and Y is hydrogen, (Ri0)mH, -CO(CH,-)--COOH, P
polymer contains active hydrogen, and reacts with an alkaline substance to form a salt, and the resulting salt also has antifungal and antibacterial effects. Examples of the alkaline substance that reacts with the polymer to form a salt include alkali metal hydroxides and alkaline earth metal hydroxides, such as sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium hydroxide, magnesium hydroxide and barium hydroxide, and ammonia water. The polymer according to this invention, that is, poly(p-hydroxystyrene), its derivative or a salt thereof has a weight average molecular weight of at least about 1500, and preferably from about 2,000 to 5,000,000. A polymer having too low a molecular weight is volatile and unsuitable for use as an active ingredient of the antifungal and antibacterial agent of this invention.
The polymer described above can be prepared by known methods generally used in the reactions of phenols. Examples of the method or preparing p-hydroxystyrene polymers are described in Japanese Patent Application (OPI) Nos. 13694/78 (the term "OPI" as used herein means an unexamined published Japenese patent application), 109097/76, 52594/78, 22187/73, 23193/77, 58087/77, and 105389/76. Poly(p-hydroxystyrene) can be prepared by cationic, radical or thermal polymerization of p-hydroxystyrene, and polymers having a weight average molecular weight of from several hundred to about 350,000 can be easily prepared by properly selecting the polymerization conditions.A polymer having a molecular weight greater than 350,000 can be produced by radical polymerization of p-methoxystyrene or p-acyloxystyrene such as p-acetoxystyrene, followed by hydrolysis with acid or alkali. The p-hydroxystyrene polymer used in this invention may be a copolymer of p-hydroxystyrene, p-methoxystyrene or pacyloxystyrene with another vinyl monomer. Such copolymer can be produced by radical or cationic polymerization. Examples of the comonomer that can be copolymerized with phydroxystyrene, p-methoxystyrene or p-acyioxystyrene include styrene, acrylonitrile, maleic anhydride, acrylic acid, methacrylic acid, acrylamide, acrylic ester, and methacrylic ester.A polymer having a cross-linked three-dimensional network structure can be prepared by copolymerizing p-hydroxystyrene, p-methoxystyrene or p-acyloxystyrene with a polyene compound such as divinylbenzene, butadiene, isoprene, cyclopentadiene, diol ester of acrylic acid, diol ester of methacrylic acid and ethylidene norbornene.
Polymers wherein p-acyloxystyrene or p-hydroxystyrene is grafed onto a hydrocarbon polymer can be produced by irradiating a hydrocarbon polymer such as polyethylene, polypropylene or polystyrene with ionizing radiation, followed by immersing the irradiated polymer in a solution containing p-acyloxystyrene or p-hydroxystyrene. The graft type polymers are described in
Japanese Patent Publication Nos. 31234/77 and 31235/77.
The nucleus of the p-hydroxystyrene polymer can be substituted by a halogen by a known method, for instance, the method described in Japanese Patent Publication No. 33680/77. A p-hydroxystyrene polymer the nucleus of which is sulfonated is described in, say, Japanese
Patent Application (OPI) No. 109097/76 according to which, a p-hydroxystyrene polymer is dissolved in a solvent such as acetic acid and treated with a sulfonating agent such as sulfuric anhydride at from 20"C to 60'C.
An ether of p-hydroxystyrene polymer wherein Y is methyl can be readily obtained by treating a solution of the polymer in a solvent (e.g., tetrahydrofuran) with diazomethane at room temperature. An ether of p-hydroxystyrene polymer wherein Y is alkyl or aromatic substituted alkyl is prepared by first treating a solution of the polymer in a solvent (e.g., dioxane) with aqueous sodium hydroxide to form a salt wherein Y is Na and then by reacting the salt with a halogenated hydrocarbon such as alkyl iodide, alkyl bromide, or benzyl iodide at 50"C to 150"C (the Williamson process).An ether of p-hydroxystyrene polymer wherein Y is -RlO)mH can be obtained by treating a solution of the polymer in a solvent (e.g., dioxane) with an alkylene oxide (e.g., ethylene oxide, propylene oxide, or butylene oxide) in the presence of an alkali catalyst at from 50'Cto 150"C.
An ester of p-hydroxystyrene polymer wherein Y is
can be obtained by first treating a solution of the polymer in a solvent (e.g., dioxane) with sodium hydroxide to form a salt wherein Y is Na and then by reacting the salt with an acid anhydride or acid chloride of mono- or dicarboxylic acid at from 0 C to 150"C. Examples of the carboxylic acid include formic acid, acetic acid, trichloroactic acid, propionic acid, butyric acid, pivalic acid, stearic acid, lauric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, sebacic acid, benzoic acid, and phthalic acid. Derivatives of a poly(p-hydroxystyrene) wherein Y is
are described in Japanese Patent Application (OPI) No. 52594/78.A derivative of poly(p hydroxystyrene) wherein Y is
,can be prepared by treating a solution of the polymer in a solvent (e.g., dioxane) with aqueous sodium hydroxide to form a sodium salt which is then treated with chlorosulfonic acid at from 0 C to 100"C. An ester of poly(p-hydroxystyrene) wherein Y is
can be prepared by treating a solution of the polymer in a solvent (e.g., tetrahydrofuran) with sodium hydroxide to form a salt wherein Y is Na and then by reacting the salt with an acid chloride of aryl sulfonic acid such as benzenesulfonyl chloride or p-toluenesulfonyl chloride at from 0 C to 150"C. As described above, these polymers react with an alkaline substance to form a salt when X, X', or Y contain active hydrogen.The method of forming the salt is described in Japanese Patent Application (OPI) No. 52594/78, etc.
Typical examples of poly(p-hydroxystyrene), its derivatives and salts thereof are identified in
Table 1 below. The structure of these polymers was identified by IR and NMR spectrum analysis, and their weight average molecular weights were determined by gel-permeation chromatography.
Table 1
Molecular Elemental IR Adsorption Analysis Analysis Comp. Weight Wt% Found Frequency No. Structural Formula (mew) (Calculated) (cm 1) No. 1 ' CH-CH2 - 4,000 C: 79.8 (80.0) 3400S CH-CH2 15205 H: 6.61 (6.67) 1240S OH 8305 No. 2 - ' CH-CH2 - 4,500 C: 68.5 (67.6) I\ H: 4.88 (4.93) Na:16.0 (16.2) N ONa z n No. 3 e CH-CH2 5,000 K: 24.8 (24.7) In OK n , No. 4 z' CH-CH2 z - 8,200 C: 65.1 (65.7) 1510S 11805 830S 5 < CH3 H- Si02 (Sill) 1180055 n Table 1 (continued)
No. 5 - - CH-CH2 ~ 6,100 C: 42.8 (43.2) 1500M 5CH-CH2 1240S H: 3.11 (3.15) 830M < O S: 13.9 (14.4) O - S - ONa Na:10.5 (10.4) O n No. 6 - - CH-CH2 ---- ~ 5,000 C: 73.6 (73.2) 3400S H: 7.16 (7.32) 15003 C2H40H/ Ö C2H4OH , n No. 7 - ' CH - -- 7,400 C: 39.6 (40.3) 3500S 7CH-CH2 2.65 Br H: 2.65 (2.73) 1160S 11605 OOH Br:50.O (50.3) OH , n 740S No. 8- CH-CH2 - - 7,900 C: 39.9 (39.0) 35005 8CH-CH2 14905 H: 2.91 (2.85) 820M 820M OH n 51.9 (51.6) 7305 No. 9- ~ CH-CH2- 8,300 Br:46.4 (46.1) Br t rl.5 Na:8.80 (8.83) ONa , n Table 1 (continued)
3450S No.10 - > CH - CH2- ClH CH- - 9,500 C: 65.1 (66.1) 3450S CO CO t H: 4.62 (4.59) 152us 0 CO 1220S OH n 830M No.ll Polyethylene on which 1 x 106 C: 81.8 (81.1) 3400S 1520S p-hydroxystyrene is H: 8.00 (8.11) 1240S grafted 830S 7205 No.12 2,300 C: 55.8 (55.9) 3500S 2 1480S H: 3.61 (3.78) 11005 Cl15 cm:30.2 (31.0) 850M OH 7605 OH , n No.13 - / CH-CH2 > ~ 3,400 C: 38.2 (37.5) 1343500so t H: S. 3.06 (3.13) 14505 OH v n n No.14 / CH-CH2 4,100 S: 16.7 (17.2) CH-CHZ s ONa > n Table 1 (continued)
No. 0 - t z 1,900 C: 80.4 (80.6) 15105 s 7.38 (7.46) , n No.16 t t. t 2,200 C: 81.7 (81.5) 1510S CH2 CH2 (8.64) 1823400M5 No.17 ;'" CHZ L 1,800 C: 71.9 (73.0) 1750S CH-CH2 lSOOM 12403 O - C - H n No.18 t ' CH-CH2 \ - 2,000 C: 73.6 (74.1) 1750S CH-CH2 lSOOM ( 1 H: 6.22 (6.17) 1240S O-0C"-C}{3m n No.19 L / H-CH2 2,500 C: 62.9 (62.5) 17505 H: 4.06 (4.17) 1710M (;C-CO 11 4.06 n II 840M OHn 1220M 17505 No.20 r CH-CH23,000 C: 65.9 (66.7) 1710M H: CCH2)3COO:5: H: 6.04 (5.98) 1510S o 1220M O - C - (CH2)3CO n Table 1 (continued)
No.21 CH-CH23,200 Na:8.96 (8.98) > ONa O - C - (CH2)3CO n No.22 - CH- CH2 - 6,500 C: 48.7 (48.0) 34005 O P: 15.1 (15.5) 12205 H: 4.44 (4.50) 12205 II 830M P n One.23 - - CH-CH2 9,000 P: 11.0 (11.2) K: 28.2 (28.3) O - P ~ t n No.24 H2 6,800 C: 43.2 (44.4) 34005 CH-C - - CH-CH2 - - 15205 H: 4.14 (4.17) 1240S S S P: 13.9 (14.4) 970W Ot ~ OH S: 13.7 (14.8) 8305 POH n 1730S No.25 H-CH2 7,000 C: 80.0 (80.4) lSlOM H: 5.41 (5.36) 1200M < O - C < n No.26 - - CH-CH2 16,000 C: 42.1 (42.8) 114600sus Br by H: 3.29 (3.37) 870M 9 1.5 Br:48.1 (47.5) 740S Br:48.1 (47.5) 740S Table 1 (continued)
No.27 t CH-CH ~ 14,000 C: 49.8 (50.5) 34005 CH-CH2 15008 H: 4.73 (4.67) 12405 S: S: 14.5 (15.0) 11300bus5 -CH3 No 28 / CH-CH - - 18,000 C: 42.5 (42.5) 3400S 1480S 12205 rs Br . S Br:41.7 (42.5) 870M 740M C2H410H , n n No.29 - / 1 z 18,000 C: 41.9 (42.8) 1750S CH-CH2 2.99 t H: 2.99 (42.8) 11605 O- C-- CH n (42.8) 870M 7405 3 n No.30 - CH-CH2 - - 21,000 C: 30.6 (30.1) 34005 C 15005 Br by H: 2.41 (2.35) 1210S t bur:37.9 (37.7) 830M 7405 ,OH 0 n No.31 13,000 C: 33.3 (34.3) 34005 No.31 t ' CHZ------1F- 13,000 C: 33.3 (34.3) lSlSM H: 2.84 (2.86) 1170S t SO3H S: 20.9 (22.9) 830M O - Sl - OH n Table 1 (continued)
No.32 Copolymer of 6,500 C: 85.1 (83.3) 34005 p-hydroxystyrene H: 7.17 (6.94) 1520S and styrene H: 7.17 (6.94) 12405 (mol. ratio10.70:0.30) 830S No.33 Copolymer of 7,300 C: 77.1 (77.8) 34005 p-hydroxystyrene H: 6.53 (6.48) 2230M and acrylonitrile H: 6.53 (6.48) 15105 (mol. ratio-0.66:0.34) N: 4.84 (4.90) 1215S 8305 No.34 Copolymer of 6,000 C: 71.6 (72.7) 3400S p-hydroxystyrene H: 6.33 16.40) 17105 and acrylic acid 15205 (mol. ratio=0.65:0.35) 12405 830S No.35 Copolymer of > 1 x 104 C: 79.4 (77.1) 17505 p-acetoxystyrene 1500EI and divinylbenzen H: 6.61 (6.43) 12405 (mol. ratio=0.80:0.20) 830S No.36 Copolymer of > 1 x 104 C: 77.2 (75.0) p-acetoxystyrene H: 6.68 (6.49) 151OM and butadiene H: 6.68 12405 (mol. ratio-0.83:0.17) 840S 10 35005 No.37 < CH-CH2 2.3 x 105 C: 47.7 (48.2) 3500S 5 3.46 (3.52) 11805 Br Br:40.0 (40.2) 8205 OHn 740M No.38 - - CH-CH2- - 4.5 x 106 C: 48.5 (48.2) 35005 No.38CH 1500S H: 3.64 (3.52) 11805 n Br Br:39.8 (40.2) 740S.
Or , n OH Table (continued)
No.39 ; - CH-CH - - 2.0 x 105 C: 64.5 (64.1) 1480S .39CH-CH2 1240S H: 5.38 (5.34) 850M C1 850M OCH3 Cl:20.7 (21.1) n No.40 - - CH-CH - - 4,500 C: 70.1 (69.6) 3500S CH-CH2 1500S H: 5.01 (5.07) 1500S F F F: 13.0 (13.8) 820M OH 7705 3400S No.41 K t CH-CH2 z - 12,500 C: 66.8 (67.3) 13500S H: H: 9.26 (9.27) 1500S s o(C3H60)5H, n No.42 - ' CH-CH2 z ~ 7,000 C: 85.3 (85.7) 15005 1200M 1200M H: 6.66 (6.63) 1100S > O - CH2 820M No.43 - ' CH-CH2 - 8,600 C: 44.9 (45.2) 1750S CH-CH2 lSlOM H: 2.70 (2.64) 125405 12405 O--CC1n CC13 , n Notes: (1) The symbol n represents the degree of polymerization.
(2) The nuclear substituent in compounds Nos. 7, 9, 12, 13, 14, 26, 28, 29 and 30 was in orthoposition with respect to the hydroxy or substituted-hydroxy group.
(3) Compound No. 11 was prepared by grafting 100% p-acetoxystyrene onto a polyethylene film (200 microns thick) obtained by low pressure polymerization process by means of irradiation with ionizing radiation, followed by hydrolysis of the acetoxy group.
(4) IR absorption frequency refers to characteristic absorptions, with S, M and W representing strong, medium and weak absorptions, respectively.
The poly(p-hydroxystyrene), its derivatives and salts thereof contained as effective ingredients in the antifungal and antibacterial agent of this invention are incorporated in materials in which they are used either directly or after being dispersed in a carrier or dissolved in a solvent.
Conventional methods of incorporation can be used, including coating, spraying, kneading, immersion and hot spraying. The polymer can be incorporated in liquids simply by mixing.
Examples of the material to which the antifungal and antibacterial agent according to this invention can be applied include wood, pulp, white water from paper making machines, bamboo, rush, polymeric substances such as plastics, water-soluble metal working oil, watersoluble hydraulic fluid, water-soluble quenching oil, paints, adhesives, glue, starch, sizing agent, hides and leather, foods, medicines, and cosmetics. The antifungal and antibacterial agent is generally incorporated in these materials in such an amount that the polymer constituting the effective ingredient is present at a concentration of from about 0.5 to 10,000 ppm (by weight).
The poly(p-hydroxystyrene), its derivatives or salts thereof used in this invention are unique in that unlike conventional antifungal and antibacterial agents, they exhibit antibacterial and antifungal effect without volatilizing and present little or no toxicity to the human body. A group of mice administered poly(p-hydroxystyrene) did not change greatly in their general conditions and their internal organs did not exhibit any abnormal conditions when it was administered orally in a single dose (1000 mg/kg), or in divided portions (500 mg/kg X 7 for 14 days, i.e., 500 mg/kg per two days X 7), or administered subcutaneously (10 g/kg).Another group of mice administered a derivative of poly(p-hydroxystyrene) wherein the nucleus was brominated did not change greatly in their general conditions or their internal organs did not exhibit any abnormal conditions, when it was administered orally in divided portions (500 mg/kg per day for 1 5 days). Because of this low toxicity, it is practically impossible for animals to be administered a lethal dose of the polymer according to this invention.
The poly(p-hydroxystyrene), its derivatives and salts thereof do not sublime, and they are free from blooming or bleeding in which their vapor crystallizes and condenses in a closed container or migrates to the surface of a material in which they are incorporated. Therefore, they do not cause any harm to a lens, shutter, and other parts in precision instruments such as a camera or microscope. Since they have virtually no vapor pressure and do not sublime, they can be used with advantage for preventing the growth of fungi on films that need extended storage. Paint, wall paper and synthetic leather containing the polymer according to this invention are protected from mold attack, and wood impregnated therewith is protected against fungal growth.Other characteristics of the poly(p-hydroxystyrene), its derivatives and salts thereof are: they do not reduce electrical properties (i.e., dielectric breakdown resistance (BDV), and volume resistance (IR)); they do not corrode metals; they do not impair the appearance or characteristics of natural or synthetic fibers, hides and leather, and paper. Because of these advantages, the polymer according to this invention can find numerous uses.
This invention is now described in greater detail by reference to the following examples and comparative example, which are provided here for illustrative purposes only, and are not intended to limit the scope of the invention.
Example 1
Compounds Nos. 1 to 11 noted in Table 1 were diluted in ethanol, and 1 ml of each ethanol dilution was injected into plate culture media having the final concentrations of 1000 ,ag/ml, 500 jug/ml, 250,ug/ml, 100,ug/ml, 50,ug/ml, 25 pg/ml and 10 pg/ml. Test microorganisms were transplanted to the media, where bacteria were cultured at 37"C for 48 hours, and fungi at 25"C for 7 days, for determination of the minimum inhibitory concentration (MIC) (in ,ug/ml) of each compound. The media for cultivation of bacteria consisting of a common agar culture medium of Eiken-sha, Japan (0.05 g of meat extract, 0.1 g of peptone, 0.05 g of sodium chloride, 0.15 g of agar, and 10 ml of purified water, pH = 7). Those for cultivation of fungi consisted of Sabouraud culture medium (0.3 g of glucose, 0.1 g of peptone, 0.15 9 of agar, and 10 ml of purified water, pH = 6.5). The results are shown in Table 2 below.
Table 2
Compound
Microorganism No. 1 No. 2 No. 3 No. 4 No. 5 No. 6 No. 7 No. 8 No. 9 No. 10 No. 11
Staphylococcus aureus 209 PJC-1 250 500 500 250 250 250 50 50 50 500 500
Bacillus subtilis
PCI-219 250 500 500 250 250 250 250 250 100 250 500
Sarcina lutea
ATCC-1001 500 500 500 500 1000 250 10 250 500 100 100
Escherichia coli
NIHJ 10 25 25 100 100 10 10 25 25 50 100
Salmonella typhi
H-901W 25 50 100 100 100 25 24 50 50 25 100
Pseudomonas Aeruginosa
IFO-3080 25 50 50 25 50 25 50 50 50 50 100
Candida albicans
ATCC-7491 250 250 100 250 240 100 250 100 250 250 500
Saccharomyces cerevisiae 250 250 250 500 500 500 250 250 250 250 500
Trichophyton interdigital 10 25 25 100 100 100 10 10 50 25 100
Microsporium gypseum 10 10 25 100 100 25 25 50 25 10 50
Penicillium chrysogenum 50 100 100 50 100 25 100 100 250 100 250
Asperfillus niger
ATCC-6275 50 50 50 100 50 50 50 50 50 100 50 Example 2
Mice were administered orally with a single dose of compound Nos. 1 to 11 of this invention for determination of the lethal dose LD50. The results are shown in Table 3 below.
Table 3
Sample Lethal Dose LD50 (g/kg)
No. 1 > 15
No. 2 > 15
No. 3 > 15
No. 4 10
No. 5 > 15
No. 6 10
No. 7 1
No. 8 2
No. 9 2
No. 10 10
No. 11 > 15
Example 3
The procedure of Example 1 was repeated using compound Nos. 1 2 to 43 of this invention for determination of their MIC. The test microorganisms were Escherichia coli NIHJ, Penicillium chrysogenum and Asperigillus niger ATCC-6275, and each compound was used in concentrations of 50, 100 and 250,ug/ml. The results are shown in Table 4.
Example 4
Mice were administered orally in single doses of 0.5 g/kg, 2 g/kg, and 5 g/kg, compound
Nos. 1 2 to 43 in the same manner as in Example 2. The lethal doses LD50 of the respective compounds are shown in Table 4.
Table 4
MIC (yg/ml) Lethal Dose, LD50
Sample E.C. P.C. A.N. (g/kg)
No. 12 50 50 5
No. 13 50 100 > 5 No. 14 50 50 > 5
No. 15 50 50 5
No. 16 50 50 5
No. 17 50 100 5
No. 18 50 100 > 5
No. 19 100 100 > 5
No. 20 50 100 > 5
No. 21 100 250 > 5
No. 22 50 50 2
No. 23 50 50 2
No. 24 50 50 2 No. 25 50 100 > 5
No. 26 50 50 0.5
No. 27 100 100 > 5
No. 28 50 50 2
No. 29 50 50 2
No. 30 50 50 0.5
No. 31 50 100 > 5
No. 32 250 250 > 5
No. 33 50 100 > 5
No. 34 100 250 > 5
No. 35 50 100 > 5
No. 36 50 100 > 5
No. 37 50 50 2
No. 38 50 50 5
No. 39 50 50 2 No.40 100 50 5
No. 41 100 250 > 5
No. 42 50 50 5
No. 43 50 50 5
Notes: E.C.: Escherichia coli NIHJ
P.C.: Penicillium chrysogenum
A.N.: Aspergillus niger ATCC-6275
The absence of MIC values means that the samples were not
tested.
Comparative Example 1
For comparison, the MIC of a phenolic novolak resin (m.w. = 500) prepared by reacting pcresol and formaldehyde in the presence of an acid catalyst was determined to be 1500,ug/ml against Escherichia coli NIHJ and 2000 yg/ml against Asperigillus niger ATCC-6275.
Example 5
A test was conducted to determine the effectiveness of the antifungal and antibacterial agent of this invention when it was applied to walls: a mixture of 500 ppm of compound No. 1 with an acrylic emulsion paint (composed of 15% polyacrylate, 5.4% rutile titanium dioxide, 12% aluminum silicate, 50% water, and the balance thickener, dispersant, and defoaming agent) was applied to a test piece and left to stand at 35C and 80% relative humidity. Even after 6 months, no mold grew on the treated surface of the test piece. No mold grew on the surface of a test piece which was treated with compound No. 7 in the same manner. When a test piece was treated with the acrylic emulsion paint that did not contain the effective ingredient of this invention, mold appeared on the treated surface after one month.
Example 6
To a sample of white water from the paper making machine in a paper mill, 250 ppm of compound No. 1 of this invention was added, and the mixture was held at 35 C. Little fungal growth (a few colonies/ml) was observed even after 5 days of storage. The same test was conducted with compound No. 7 and little fungal growth was observed. However, when the white water did not contain the effective ingredient of this invention, much mold (1 X 108 colonies/ml) appeared in only 2 days.
Claims (30)
1. An antifungal and antibacterial agent including as an effective ingredient poly(phydroxystyrene), a derivative of said poly(p-hydroxystyrene), or a salt thereof, each having a molecular weight of at least about 1 500.
2. An antifungal and antibacterial agent according to Claim 1 wherein the effective ingredient is a poly(p-hydroxystyrene) or its derivative, each comprising at least 1 2 polymeric units represented by formula (I)
wherein X and X' are each hydrogen, halogen, or -SO3H, Y is hydrogen, residue of an alcohol except for the -OH group, or residue of an organic or inorganic acid except for the -OH group, or a salt thereof.
3. An antifungal and antibacterial agent according to Claim 2 wherein Y is: hydrogen; an alkyl group; and aromatic substituted alkyl group; -(RaO)mH, wherein R1 is an alkylene group having two or more carbon atoms, and m is an integer of at least 1; and
wherein R2 is hydrogen, an alkyl group, a halogen substituted alkyl group, an aromatic group.
or -(CH2)pCOOH, wherein p is 0 or an integer of at least 1;
wherein R3 is an aromatic group,
4. An antifungal and antibacterial agent according to Claim 2 or 3 wherein the poly(phydroxystyrene), or derivative thereof is a copolymer of p-hydroxystyrene or a derivative thereof and another vinyl monomer.
5. An antifungal and antibacterial agent according to Claim 2 or 3 wherein the p
hydroxystyrene, its derivative, or a salt thereof comprises at least 1 6 polymeric units represente
by formula (I).
6. An antifungal and antibacterial agent according to Claim 2 or 3 wherein the poly(p hydroxystyrene)l its derivative, or a salt thereof has a molecular weight of from 2,000 to 5,000,000.
7. An antifungal and antibacterial agent according to Claim 2 wherein the effective
ingredient is poly(p-hydroxystyrene).
8. An antifungal and antibacterial agent according to Claim 2 wherein the effective
ingredient is an alkali metal salt of poly(p-hydroxystyrene).
9. An antifungal and antibacterial agent according to Claim 2 wherein the effective
ingredient is poly(p-hydroxystyrene) halogenated at at least one position ortho- to the hydroxy
group.
10. An antifungal and antibacterial agent according to Claim 2 wherein the effective
ingredient is an alkali metal salt of poly(p-hydroxystyrene) halogenated at at least one position
ortho- to the hydroxy group.
11. An antifungal and antibacterial agent according to Claim 2 wherein the effective
ingredient is a copolymer of p-hydroxystyrene and maleic anhydride.
1 2. An antifungal and antibacterial agent according to Claim 2 wherein the effective
ingredient is polyethylene on which p-hydroxystyrene is grafted.
1 3. An antifungal and antibacterial agent according to Claim 2 wherein the effective
ingredient is poly(p-alkoxystyrene).
1 4. An antifungal and antibacterial agent according to Claim 2 wherein the effective
ingredient is poly(p-acyloxystyrene).
1 5. An antifungal and antibacterial agent according to Claim 2 wherein the effective
ingredient is poly(p-hydroxystyrene) sulfonated at at least one position ortho- to the hydroxy
group.
1 6. An antifungal and antibacterial agent according to Claim 2 wherein the effective
ingredient is an alkali metal salt of poly(p-hydroxystyrene) sulfonated at at least one position
ortho- to the hydroxy group.
17. An antifungal and antibacterial agent according to Claim 2 wherein the effective
ingredient is a polymer having a repeating unit of formula (II)
18. An antifungal and antibacterial agent according to Claim 2 wherein the effective ingredient is a polymer having a repeating unit of formula (III)
1 9. An antifungal and antibacterial agent according to Claim 2 wherein the effective ingredient is a polymer having a repeating unit of formula (1V)
20. An antifungal and antibacterial agent according to Claim 2 wherein the effective ingredient is a polymer having a repeating unit of formula (V)
21.A material containing an antifungal and antibacterial agent including as an effective ingredient poly(p-hydroxystyrene), a derivative of said poly(p-hydroxystyrene), or a salt thereof, each having a molecular weight of at least about 1 500.
22. A material as in Claim 21 wherein the effective ingredient is a poly(p-hydroxystyrene) or its derivative, each comprising at least 12 polymeric units represented by formula (I)
wherein X and X' are each hydrogen, halogen, or -SO3H, Y is hydrogen, residue of an alcohol except for the -OH group, or residue of an organic or inorganic acids except for the -OH group, or a salt thereof.
23. A material as in Claim 22 wherein Y is: hydrogen; an alkyl group; an aromatic substituted alkyl group; -(RrO)mH, wherein R, is an alkylene group having two or more carbon atoms, and m is an integer of at least 1; and
wherein R2 is hydrogen, an alkyl group, a halogen substituted alkyl group, an aromatic group, or -(CH2)pCOOH, wherein p is O or an integer of at least 1;
wherein R3 is an aromatic group.
24. A material according to Claim 21, 22 or 23, wherein the material selected from the group consisting of wood, pulp, white water from paper making machines, bamboo, rush, polymeric substances, water-soluble metal working oil, water-soluble hydraulic fluid, watersoluble quenching oil, paint, adhesive, glue, starch, sizing agent, hides and leather, food, medicine, and a cosmetic.
25. A material as in Claim 21, 22, or 23, wherein the effective ingredient is present in a concentration of from 0.5 to 10,000 ppm.
26. A material as in Claims 21, 24, wherein the effective ingredient is present in a concentration of from 0.5 to 10,000 ppm.
27. A method of protecting a material against fungi and bacteria comprising the step of applying thereto an antifungal and antibacterial agent including as an effective ingredient poly(phydroxystyrene), a derivative of said poly(p-hydroxystyrene), or a salt thereof, each having a molecular weight of at least about 1 500.
28. An antifungal and antibacterial agent as claimed in Claim 1 substantially as hereinbefore described.
29. A method as claimed in Claim 27 of protecting a material against fungi and bacteria substantially as hereinbefore described with reference to Example 5 or Example 6.
30. A material protected against fungi and bacteria by a method as claimed in Claim 27 or
Claim 29.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2454480A JPH0229644B2 (en) | 1980-02-27 | 1980-02-27 | BOKABI * SATSUKINZAI |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2072508A true GB2072508A (en) | 1981-10-07 |
| GB2072508B GB2072508B (en) | 1983-06-08 |
Family
ID=12141085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8105672A Expired GB2072508B (en) | 1980-02-27 | 1981-02-23 | Antifungal and antibacterial agent |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPH0229644B2 (en) |
| DE (1) | DE3107578A1 (en) |
| FR (1) | FR2476441A1 (en) |
| GB (1) | GB2072508B (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000016624A1 (en) * | 1998-09-23 | 2000-03-30 | Phycogen, Inc. | Safe and effective biofilm inhibitory compounds and health-related uses thereof |
| FR2783710A1 (en) * | 1998-09-25 | 2000-03-31 | Oreal | USE OF POLYMERS SUSCEPTIBLE OF BEING OBTAINED FROM HYDROXYSTYRENE IN HAIR COMPOSITIONS |
| FR2783709A1 (en) * | 1998-09-25 | 2000-03-31 | Oreal | COSMETIC COMPOSITION COMPRISING AT LEAST ONE POLYMER CAPABLE OF BEING OBTAINED FROM HYDROXYSTYRENE |
| EP1025832A1 (en) * | 1999-02-05 | 2000-08-09 | L'oreal | Cosmetic composition containing a poly(hydroxystyrene) in an aqueous medium |
| EP1025831A1 (en) * | 1999-02-05 | 2000-08-09 | L'oreal | Cosmetic composition containing poly(hydroxystyrene) and a fatty phase |
| WO2000074645A1 (en) * | 1999-06-09 | 2000-12-14 | L'oreal | Aqueous carrier systems for water-insoluble aromatic polymers |
| US6610282B1 (en) * | 1998-05-05 | 2003-08-26 | Rohm And Haas Company | Polymeric controlled release compositions |
| WO2004032628A1 (en) * | 2002-10-07 | 2004-04-22 | Basf Aktiengesellschaft | Method for the destruction of microorganisms |
| WO2007053466A1 (en) * | 2005-10-28 | 2007-05-10 | E. I. Du Pont De Nemours And Company | Poly(hydroxystyrene) stain resist |
| US20150323866A1 (en) * | 2013-03-22 | 2015-11-12 | Jsr Corporation | Radiation-sensitive resin composition, resist pattern-forming method, polymer, and method for producing compound |
| EP3378910A1 (en) * | 2017-03-24 | 2018-09-26 | Seiko Epson Corporation | Water-based ink composition for ink jet recording and coloring material liquid |
| EP3378909A1 (en) * | 2017-03-24 | 2018-09-26 | Seiko Epson Corporation | Water-based ink composition for ink jet recording and coloring material liquid |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6048990A (en) * | 1989-09-20 | 1991-04-18 | Ecolab Inc. | Antimicrobial polymeric coating |
| EP0891708A1 (en) * | 1997-07-17 | 1999-01-20 | The Procter & Gamble Company | Anti-microbic agent |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE637090A (en) * | 1963-01-03 | 1900-01-01 | ||
| JPS51105389A (en) * | 1975-03-01 | 1976-09-17 | Kenji Kanezaki | Kojundo pp binirufuenoorujugotaino seizohoho |
| JPS51109097A (en) * | 1975-03-22 | 1976-09-27 | Maruzen Oil Co Ltd | HORIPARAHIDO ROKISHISUCHIRENNO SURUPPONKABUTSUNOSEIHO |
| JPS5223193A (en) * | 1975-08-15 | 1977-02-21 | Cosmo Co Ltd | Preparation of microporous resin |
| JPS5352594A (en) * | 1976-10-23 | 1978-05-13 | Cosmo Co Ltd | Phosphoric acid or its derivative group-containing hydroxy styrene typeplymer and its preparation |
-
1980
- 1980-02-27 JP JP2454480A patent/JPH0229644B2/en not_active Expired - Lifetime
-
1981
- 1981-02-23 GB GB8105672A patent/GB2072508B/en not_active Expired
- 1981-02-27 FR FR8104025A patent/FR2476441A1/en not_active Withdrawn
- 1981-02-27 DE DE19813107578 patent/DE3107578A1/en not_active Withdrawn
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610282B1 (en) * | 1998-05-05 | 2003-08-26 | Rohm And Haas Company | Polymeric controlled release compositions |
| WO2000016624A1 (en) * | 1998-09-23 | 2000-03-30 | Phycogen, Inc. | Safe and effective biofilm inhibitory compounds and health-related uses thereof |
| FR2783710A1 (en) * | 1998-09-25 | 2000-03-31 | Oreal | USE OF POLYMERS SUSCEPTIBLE OF BEING OBTAINED FROM HYDROXYSTYRENE IN HAIR COMPOSITIONS |
| FR2783709A1 (en) * | 1998-09-25 | 2000-03-31 | Oreal | COSMETIC COMPOSITION COMPRISING AT LEAST ONE POLYMER CAPABLE OF BEING OBTAINED FROM HYDROXYSTYRENE |
| WO2000018360A1 (en) * | 1998-09-25 | 2000-04-06 | L'oreal | Use of polymers obtainable from hydroxystyrene in hair compositions |
| WO2000018359A1 (en) * | 1998-09-25 | 2000-04-06 | L'oreal | Cosmetic composition comprising at least a polymer obtainable from a hydroxystyrene |
| EP1025832A1 (en) * | 1999-02-05 | 2000-08-09 | L'oreal | Cosmetic composition containing a poly(hydroxystyrene) in an aqueous medium |
| EP1025831A1 (en) * | 1999-02-05 | 2000-08-09 | L'oreal | Cosmetic composition containing poly(hydroxystyrene) and a fatty phase |
| FR2789305A1 (en) * | 1999-02-05 | 2000-08-11 | Oreal | COSMETIC COMPOSITION CONSISTING OF A POLY (HYDROXYSTYRENE) AND A FAT PHASE |
| FR2789306A1 (en) * | 1999-02-05 | 2000-08-11 | Oreal | COSMETIC COMPOSITION COMPRISING POLY (HYDROXYSTYRENE) IN AQUEOUS MEDIUM |
| US6436436B1 (en) | 1999-06-09 | 2002-08-20 | L'oreal S.A. | Aqueous carrier systems for water-insoluble aromatic polymers |
| WO2000074645A1 (en) * | 1999-06-09 | 2000-12-14 | L'oreal | Aqueous carrier systems for water-insoluble aromatic polymers |
| WO2004032628A1 (en) * | 2002-10-07 | 2004-04-22 | Basf Aktiengesellschaft | Method for the destruction of microorganisms |
| US7645419B2 (en) | 2002-10-07 | 2010-01-12 | Basf Se | Killing microorganisms |
| WO2007053466A1 (en) * | 2005-10-28 | 2007-05-10 | E. I. Du Pont De Nemours And Company | Poly(hydroxystyrene) stain resist |
| US20150323866A1 (en) * | 2013-03-22 | 2015-11-12 | Jsr Corporation | Radiation-sensitive resin composition, resist pattern-forming method, polymer, and method for producing compound |
| US9703195B2 (en) * | 2013-03-22 | 2017-07-11 | Jsr Corporation | Radiation-sensitive resin composition, resist pattern-forming method, polymer, and method for producing compound |
| EP3378910A1 (en) * | 2017-03-24 | 2018-09-26 | Seiko Epson Corporation | Water-based ink composition for ink jet recording and coloring material liquid |
| EP3378909A1 (en) * | 2017-03-24 | 2018-09-26 | Seiko Epson Corporation | Water-based ink composition for ink jet recording and coloring material liquid |
| CN108624141A (en) * | 2017-03-24 | 2018-10-09 | 精工爱普生株式会社 | Water-based ink for use in ink-jet recording composition and colorant liquid |
| CN108624138A (en) * | 2017-03-24 | 2018-10-09 | 精工爱普生株式会社 | Water-based ink for use in ink-jet recording composition and colorant liquid |
| CN108624141B (en) * | 2017-03-24 | 2021-10-29 | 精工爱普生株式会社 | Aqueous ink composition and colorant liquid for inkjet recording |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2072508B (en) | 1983-06-08 |
| JPH0229644B2 (en) | 1990-07-02 |
| FR2476441A1 (en) | 1981-08-28 |
| JPS56120601A (en) | 1981-09-22 |
| DE3107578A1 (en) | 1981-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |