GB1534387A - D-threo-1-phenyl-2-trifluoroacetamido-1,3-propanediol derivatives - Google Patents
D-threo-1-phenyl-2-trifluoroacetamido-1,3-propanediol derivativesInfo
- Publication number
- GB1534387A GB1534387A GB32845/77A GB3284577A GB1534387A GB 1534387 A GB1534387 A GB 1534387A GB 32845/77 A GB32845/77 A GB 32845/77A GB 3284577 A GB3284577 A GB 3284577A GB 1534387 A GB1534387 A GB 1534387A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- ch3o2s
- formula
- stands
- denotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 229960002449 glycine Drugs 0.000 abstract 2
- 235000013905 glycine and its sodium salt Nutrition 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 methylmercapto compound Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The compounds of the annexed formula <IMAGE> in which R stands for CH3S- or CH3O2S- and R1 stands for hydrogen or, if R denotes CH3O2S-, for an acyl radical of an aliphatic carboxylic acid having 15-17 C atoms or aminoacetic acid, are prepared by reaction of a compound of the annexed formula <IMAGE> with free trifluoroacetic acid or a functional derivative thereof. The corresponding esters, if R stands for CH3O2S-, are obtained by subsequent esterification to give the corresponding compound in which R1 is an acyl radical. The compound of the formula Ia in which R denotes CH3O2S and R1 denotes hydrogen is also prepared by oxidation of the corresponding methylmercapto compound using a peroxide compound. The esters of aminoacetic acid of the formula Ia can be converted into the corresponding therapeutically utilisable acid addition salts. The compounds obtained show a broad antibiotic spectrum of action and are highly suitable for use in human medicine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT26042/76A IT1065143B (en) | 1976-08-05 | 1976-08-05 | D-TREO-1-FENYL-2-TRIFLUOROACETAMIDO-1,3-PROPANDIOL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1534387A true GB1534387A (en) | 1978-12-06 |
Family
ID=11218484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32845/77A Expired GB1534387A (en) | 1976-08-05 | 1977-08-05 | D-threo-1-phenyl-2-trifluoroacetamido-1,3-propanediol derivatives |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5321135A (en) |
| AT (1) | AT351018B (en) |
| AU (1) | AU509278B2 (en) |
| BE (1) | BE857543A (en) |
| CA (1) | CA1087207A (en) |
| CH (1) | CH609338A5 (en) |
| DE (1) | DE2735431A1 (en) |
| ES (1) | ES461093A1 (en) |
| FR (1) | FR2360560A1 (en) |
| GB (1) | GB1534387A (en) |
| HU (1) | HU173169B (en) |
| IE (1) | IE45460B1 (en) |
| IT (1) | IT1065143B (en) |
| NL (1) | NL7708695A (en) |
| PT (1) | PT66889B (en) |
| YU (1) | YU40678B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0677511A2 (en) | 1983-06-02 | 1995-10-18 | ZAMBON GROUP S.p.A. | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5977276A (en) * | 1982-10-27 | 1984-05-02 | 松下冷機株式会社 | Ice machine |
| IT1317836B1 (en) * | 2000-02-16 | 2003-07-15 | Zambon Spa | USE OF TIAMFENICOLO FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS USEFUL FOR THE TREATMENT OF STAPHYLOCOCCI INFECTIONS |
-
1976
- 1976-08-05 IT IT26042/76A patent/IT1065143B/en active
-
1977
- 1977-07-18 YU YU1779/77A patent/YU40678B/en unknown
- 1977-07-28 ES ES461093A patent/ES461093A1/en not_active Expired
- 1977-08-04 CH CH959077A patent/CH609338A5/en not_active IP Right Cessation
- 1977-08-04 PT PT66889A patent/PT66889B/en unknown
- 1977-08-05 IE IE1643/77A patent/IE45460B1/en unknown
- 1977-08-05 JP JP9345877A patent/JPS5321135A/en active Pending
- 1977-08-05 FR FR7724168A patent/FR2360560A1/en active Granted
- 1977-08-05 NL NL7708695A patent/NL7708695A/en not_active Application Discontinuation
- 1977-08-05 AT AT577177A patent/AT351018B/en not_active IP Right Cessation
- 1977-08-05 GB GB32845/77A patent/GB1534387A/en not_active Expired
- 1977-08-05 CA CA284,228A patent/CA1087207A/en not_active Expired
- 1977-08-05 DE DE19772735431 patent/DE2735431A1/en not_active Withdrawn
- 1977-08-05 AU AU27655/77A patent/AU509278B2/en not_active Expired
- 1977-08-05 BE BE179956A patent/BE857543A/en not_active IP Right Cessation
- 1977-08-05 HU HU77CE1140A patent/HU173169B/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0677511A2 (en) | 1983-06-02 | 1995-10-18 | ZAMBON GROUP S.p.A. | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives |
| EP0678506A2 (en) | 1983-06-02 | 1995-10-25 | ZAMBON GROUP S.p.A. | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| YU177977A (en) | 1982-10-31 |
| YU40678B (en) | 1986-04-30 |
| JPS5321135A (en) | 1978-02-27 |
| PT66889B (en) | 1979-01-25 |
| AT351018B (en) | 1979-07-10 |
| IT1065143B (en) | 1985-02-25 |
| CA1087207A (en) | 1980-10-07 |
| PT66889A (en) | 1977-09-01 |
| NL7708695A (en) | 1978-02-07 |
| HU173169B (en) | 1979-03-28 |
| ATA577177A (en) | 1978-12-15 |
| CH609338A5 (en) | 1979-02-28 |
| DE2735431A1 (en) | 1978-02-09 |
| IE45460L (en) | 1978-02-05 |
| AU509278B2 (en) | 1980-05-01 |
| FR2360560B1 (en) | 1981-02-06 |
| IE45460B1 (en) | 1982-08-25 |
| BE857543A (en) | 1977-12-01 |
| FR2360560A1 (en) | 1978-03-03 |
| AU2765577A (en) | 1979-02-08 |
| ES461093A1 (en) | 1978-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK54382A (en) | Novel substituted phenoxybenzyloxycarbonyl derivatives and their use as insecticides and acaricides | |
| GB1363847A (en) | Iodinated organic acid derivatives for use as x-ray contrast agents | |
| SE7613090L (en) | PICOLIC ACID DERIVATIVE AND PROCEDURES FOR THE PREPARATION THEREOF | |
| GB1534387A (en) | D-threo-1-phenyl-2-trifluoroacetamido-1,3-propanediol derivatives | |
| DE2965574D1 (en) | Adamantylalkyloxy-carbonyl derivatives, their preparation and their use for the production of peptides | |
| ES463682A1 (en) | Derivatives of coenzyme B12 | |
| IE43830L (en) | Phenylpiperidine derivatives. | |
| GB1514389A (en) | Glycerides with antibacterial properties | |
| CH608785A5 (en) | Process for producing new N-acylglutamines | |
| IE37347B1 (en) | Oxazolo (5,4-d) azepines | |
| JPS5334719A (en) | Preparation of substituted or unsubstituted alpha-oxysuccinic acid esters | |
| ES428213A1 (en) | Dialkylaminoalkyl esters of penicillin and process for the preparation thereof | |
| CH613936A5 (en) | Process for the preparation of phenylalkyl-substituted carboxylic acids | |
| SE7600585L (en) | PROCEDURE FOR THE PREPARATION OF 7-AMINOCEFALOSPORANIC ACID DERIVATIVES | |
| GB1484986A (en) | Salts of the dimethylaminoethyl ester of p-chloro-phenoxy acetic acid | |
| CH613689A5 (en) | Process for the preparation of novel pyroglutamyl compounds | |
| GB1107036A (en) | Esters of dibenzocycloheptenyl-carboxylic acids | |
| GB1519690A (en) | Phenoxyalkane carboxylic acid derivatives | |
| GB991475A (en) | Novel steroid compounds and processes for their production | |
| GB975602A (en) | Derivatives of 14-hydroxynorcodeinone and their production | |
| GB1530667A (en) | N2-substituted argininamides | |
| JPS5283342A (en) | Synthesis of 3-chloro-4-allyloxypheny-acetic acid esters | |
| ES397708A1 (en) | Procedure for the obtaining derivatives of imidazolidinone. (Machine-translation by Google Translate, not legally binding) | |
| JPS5271439A (en) | Synthesis of phenylacetic acid derivatives | |
| GB1525434A (en) | Anti-inflammatory thiophene derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 416 | Proceeding under section 16 patents act 1949 | ||
| PS | Patent sealed | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |