IE37347B1 - Oxazolo (5,4-d) azepines - Google Patents
Oxazolo (5,4-d) azepinesInfo
- Publication number
- IE37347B1 IE37347B1 IE211/73A IE21173A IE37347B1 IE 37347 B1 IE37347 B1 IE 37347B1 IE 211/73 A IE211/73 A IE 211/73A IE 21173 A IE21173 A IE 21173A IE 37347 B1 IE37347 B1 IE 37347B1
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- formula
- group
- feb
- prepared
- Prior art date
Links
- PBTVYWXSFKOKAY-UHFFFAOYSA-N O1CN=C2C=CN=CC=C21 Chemical class O1CN=C2C=CN=CC=C21 PBTVYWXSFKOKAY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- -1 hydroxy, carboxy Chemical group 0.000 abstract 2
- UURDJNVKUSXMJK-UHFFFAOYSA-N 2h-[1,3]oxazolo[5,4-b]azepine Chemical class C1=CC=CC2=NCOC2=N1 UURDJNVKUSXMJK-UHFFFAOYSA-N 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measurement Of Radiation (AREA)
Abstract
1412377 Oxazoloazepine derivatives DR KARL THOMAE GmbH 9 Feb 1973 [10 Feb 1972] 6476/73 Heading C2C [Also in Division A5] Novel compounds of Formula I: (wherein R represents a hydrogen atom, an alkyl group containing from 1 to 4 carbon atoms substituted by a hydroxy, carboxy or carbalkoxy group; a saturated or unsaturated aliphatic acyl group containing from 1 to 6 carbon atoms optionally substituted by a hydroxyl group; a benzoyl group optionally substituted by one or more methyl or methoxy groups or by one or more halogen atoms; or a pyridinecarbonyl or phenylacyl group) and acid addition salts thereof, are prepared by reacting a compound of Formula II with urea. Intermediates of Formula II are prepared by various methods for example by the following sequence : (i) for R = H, a compound of formula is cyclized and then the N-benzyl compound is debenzylated; (ii) for R = acetyl, the compound R = H is acetylated; (iii) for R = hydroxyalkyl, the ethylene glycol ketal of the compound R = H is reacted with ethylene oxide.
[GB1412377A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2206385A DE2206385C2 (en) | 1972-02-10 | 1972-02-10 | 2-Amino-4,5,7,8-tetrahydro-6H-oxazolo- [4,5-d] azepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37347L IE37347L (en) | 1973-08-10 |
| IE37347B1 true IE37347B1 (en) | 1977-07-06 |
Family
ID=5835665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE211/73A IE37347B1 (en) | 1972-02-10 | 1973-02-09 | Oxazolo (5,4-d) azepines |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5825678B2 (en) |
| KR (1) | KR780000196B1 (en) |
| AT (1) | AT321296B (en) |
| BE (1) | BE795257A (en) |
| BG (1) | BG22826A3 (en) |
| CA (1) | CA997342A (en) |
| CH (1) | CH576476A5 (en) |
| CS (1) | CS181231B2 (en) |
| DD (1) | DD104083A5 (en) |
| DE (1) | DE2206385C2 (en) |
| DK (1) | DK137011C (en) |
| FI (1) | FI54126C (en) |
| FR (1) | FR2181718B1 (en) |
| GB (1) | GB1412377A (en) |
| HU (1) | HU165459B (en) |
| IE (1) | IE37347B1 (en) |
| IL (1) | IL41512A (en) |
| NL (1) | NL173525C (en) |
| NO (1) | NO131599C (en) |
| PL (1) | PL84740B1 (en) |
| RO (1) | RO61191A (en) |
| SE (1) | SE380805B (en) |
| SU (1) | SU474990A3 (en) |
| ZA (1) | ZA73924B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3820775A1 (en) * | 1988-06-20 | 1989-12-21 | Thomae Gmbh Dr K | NEW 4,5,7,8-TETRAHYDRO-6H-THIAZOLO (5,4, -D) AZEPINES, THEIR PREPARATION AND THEIR USE AS DRUGS |
| DE4345224C2 (en) * | 1993-12-18 | 1999-07-01 | Asta Medica Ag | Process for the preparation of acid addition salts of azelastine and flezelastin |
| CL2004000553A1 (en) | 2003-03-20 | 2005-02-04 | Actelion Pharmaceuticals Ltd | USE OF GUANIDINE DERIVATIVE COMPOUNDS AS ANTAGONISTS OF THE FF NEUROPEPTIDE RECEIVER; COMPOUNDS DERIVED FROM GUANIDINA; PREPARATION PROCEDURES; AND PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM. |
| CN1845907B (en) | 2003-09-05 | 2010-07-28 | 埃科特莱茵药品有限公司 | Guanidine derivatives |
| EP2327704A4 (en) * | 2008-08-29 | 2012-05-09 | Shionogi & Co | Ring-fused azole derivative having pi3k-inhibiting activity |
| KR20160067959A (en) | 2013-11-11 | 2016-06-14 | 가부시키가이샤 고베 세이코쇼 | Titanium separator material for fuel cells, and method for producing titanium separator material for fuel cells |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BG17968A3 (en) * | 1970-08-14 | 1974-03-05 | Dr. Karl Thomae Gmbh | METHOD FOR OBTAINING AZEPINE DERIVATIVES |
| DE2040510C3 (en) * | 1970-08-14 | 1980-03-06 | Dr. Karl Thomae Gmbh, 7950 Biberach | Oxazole and thiazole square brackets on 5,4-d] azepine derivatives |
| ZA756062B (en) * | 1975-09-23 | 1977-04-27 | M Schoeman | Supplying fuel to internal combustion engines |
-
0
- BE BE795257D patent/BE795257A/en not_active IP Right Cessation
-
1972
- 1972-02-10 DE DE2206385A patent/DE2206385C2/en not_active Expired
-
1973
- 1973-01-18 NL NLAANVRAGE7300744,A patent/NL173525C/en not_active IP Right Cessation
- 1973-01-29 AT AT73473A patent/AT321296B/en not_active IP Right Cessation
- 1973-01-29 DD DD168504A patent/DD104083A5/xx unknown
- 1973-01-31 SU SU1878315A patent/SU474990A3/en active
- 1973-02-07 KR KR7300224A patent/KR780000196B1/en not_active Expired
- 1973-02-08 CH CH187273A patent/CH576476A5/xx not_active IP Right Cessation
- 1973-02-08 HU HUTO898A patent/HU165459B/hu unknown
- 1973-02-08 BG BG022667A patent/BG22826A3/en unknown
- 1973-02-08 SE SE7301773A patent/SE380805B/en unknown
- 1973-02-09 ZA ZA730924A patent/ZA73924B/en unknown
- 1973-02-09 FR FR7304643A patent/FR2181718B1/fr not_active Expired
- 1973-02-09 CA CA163,409A patent/CA997342A/en not_active Expired
- 1973-02-09 IL IL41512A patent/IL41512A/en unknown
- 1973-02-09 NO NO533/73A patent/NO131599C/no unknown
- 1973-02-09 FI FI394/73A patent/FI54126C/en active
- 1973-02-09 JP JP48016407A patent/JPS5825678B2/en not_active Expired
- 1973-02-09 IE IE211/73A patent/IE37347B1/en unknown
- 1973-02-09 CS CS7300000974A patent/CS181231B2/en unknown
- 1973-02-09 GB GB647673A patent/GB1412377A/en not_active Expired
- 1973-02-09 DK DK74573A patent/DK137011C/en not_active IP Right Cessation
- 1973-02-09 PL PL1973160658A patent/PL84740B1/pl unknown
- 1973-02-10 RO RO73806A patent/RO61191A/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS181231B2 (en) | 1978-03-31 |
| NL173525B (en) | 1983-09-01 |
| IL41512A0 (en) | 1973-04-30 |
| ZA73924B (en) | 1974-11-27 |
| DK137011C (en) | 1978-06-05 |
| NO131599B (en) | 1975-03-17 |
| IL41512A (en) | 1976-01-30 |
| NO131599C (en) | 1975-06-25 |
| BG22826A3 (en) | 1977-04-20 |
| FI54126C (en) | 1978-10-10 |
| HU165459B (en) | 1974-08-28 |
| JPS5825678B2 (en) | 1983-05-28 |
| CH576476A5 (en) | 1976-06-15 |
| FR2181718A1 (en) | 1973-12-07 |
| DE2206385C2 (en) | 1983-04-21 |
| AT321296B (en) | 1975-03-25 |
| SE380805B (en) | 1975-11-17 |
| NL7300744A (en) | 1973-08-14 |
| GB1412377A (en) | 1975-11-05 |
| RO61191A (en) | 1976-10-15 |
| FR2181718B1 (en) | 1976-12-31 |
| NL173525C (en) | 1984-02-01 |
| AU5203573A (en) | 1974-08-15 |
| IE37347L (en) | 1973-08-10 |
| BE795257A (en) | 1973-08-09 |
| DE2206385A1 (en) | 1973-08-16 |
| KR780000196B1 (en) | 1978-05-26 |
| SU474990A3 (en) | 1975-06-25 |
| CA997342A (en) | 1976-09-21 |
| JPS4886885A (en) | 1973-11-15 |
| DD104083A5 (en) | 1974-02-20 |
| FI54126B (en) | 1978-06-30 |
| PL84740B1 (en) | 1976-04-30 |
| DK137011B (en) | 1978-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2963097D1 (en) | Process for the preparation of beta-lactam derivatives, the novel derivatives so obtainable and pharmaceutical compositions containing them | |
| ES388869A1 (en) | Cephalosporin intermediates and process therefor | |
| IE39476B1 (en) | 3-hydroxy cephalosporins their ether derivatives and methods for their preparation | |
| IE37347B1 (en) | Oxazolo (5,4-d) azepines | |
| ES8206509A1 (en) | Reactive derivatives of 3-oxa-bicyclo(4.3.0)-non-1-ene-9-one, process for their preparation and their use. | |
| ES412859A1 (en) | Process for preparing 7-(alpha-hydroxy-alpha-phenyl)acetamido-3-(1-methyl-1h-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid and derivatives thereof | |
| GB1294678A (en) | New cyclic ketal derivatives and a process for the preparation thereof | |
| GB1418598A (en) | 3-aminocarbazole derivatives and test devices containing them | |
| GB1430105A (en) | Bicyclo-octane derivatides | |
| GB1290944A (en) | ||
| GB2017087A (en) | Process for the preparation of xanthone derivatives | |
| IE781477L (en) | IMIDAZO £2,1-a| ISOINDOLES | |
| ES463682A1 (en) | Derivatives of coenzyme B12 | |
| GB2005246A (en) | beta -Lactam compounds and processes for their preparation | |
| ES385437A1 (en) | Method for the preparation of new derivatives of penicilanico acid. (Machine-translation by Google Translate, not legally binding) | |
| IE43117L (en) | Naphthacene derivatives | |
| GB1347598A (en) | Lincomycin derivatives and the manufacture thereof | |
| GB1422684A (en) | Methylfumaraldehyde monoacetals and process for making them | |
| GB1384855A (en) | 7-ypsilon-substituted propyl-theophylline derivatives and a process for producing the same | |
| JPS5265263A (en) | Azetidinone compounds | |
| GB1429861A (en) | Vincamine derivatives | |
| IL72709A (en) | 7alpha-substituted 3-oxo-17alpha-pregn-4-ene-21,17-carbolactones,process for their production,and pharmaceutical preparations containing same | |
| GB1366665A (en) | Tricyclic compounds and a process for the preparation thereof | |
| GB1305547A (en) | ||
| ES485801A1 (en) | Process for preparing cyclo-1,3,2-oxazaphosphoryl derivatives |