GB1521073A - Cephalosporin compounds - Google Patents
Cephalosporin compoundsInfo
- Publication number
- GB1521073A GB1521073A GB31598/75A GB3159875A GB1521073A GB 1521073 A GB1521073 A GB 1521073A GB 31598/75 A GB31598/75 A GB 31598/75A GB 3159875 A GB3159875 A GB 3159875A GB 1521073 A GB1521073 A GB 1521073A
- Authority
- GB
- United Kingdom
- Prior art keywords
- image
- formula
- reaction
- hand
- cephalosporin compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- -1 Cephalosporin compounds Chemical class 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel cephalosporins of the general formula <IMAGE> are obtained by reaction of a 3-acetoxymethylcephalosporin of the formula <IMAGE> with a triazinylthio derivative of the formula <IMAGE> The substituents are defined in Claim 1. If necessary, the amino and/or carboxyl groups are intermediately protected and, if it is desired, the compounds obtained according to the invention are acylated by the known processes. The reaction is preferably carried out in polar solvents, e.g. water. These novel cephalosporins are to be used on the one hand as medicines having antibiotic activity or on the other hand as intermediates in the preparation of antibiotics.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49414874A | 1974-08-02 | 1974-08-02 | |
| US58392475A | 1975-06-10 | 1975-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1521073A true GB1521073A (en) | 1978-08-09 |
Family
ID=27051316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31598/75A Expired GB1521073A (en) | 1974-08-02 | 1975-07-29 | Cephalosporin compounds |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS6123195B2 (en) |
| AR (1) | AR210998A1 (en) |
| AT (1) | AT347580B (en) |
| BG (1) | BG26395A3 (en) |
| CA (1) | CA1100129A (en) |
| CH (1) | CH616683A5 (en) |
| CS (1) | CS189716B2 (en) |
| DD (1) | DD121114A5 (en) |
| DE (1) | DE2534071A1 (en) |
| DK (1) | DK343275A (en) |
| FR (1) | FR2280381A1 (en) |
| GB (1) | GB1521073A (en) |
| HU (1) | HU174130B (en) |
| IE (1) | IE41590B1 (en) |
| IL (1) | IL47802A (en) |
| NL (1) | NL7509053A (en) |
| PH (1) | PH16078A (en) |
| PL (1) | PL95607B1 (en) |
| RO (1) | RO72980A (en) |
| SE (1) | SE426830B (en) |
| SU (1) | SU755200A3 (en) |
| YU (1) | YU197075A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4298605A (en) | 1978-06-22 | 1981-11-03 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4348518A (en) | 1974-05-05 | 1982-09-07 | Hoffmann-La Roche Inc. | Cephalosporins |
| JPS50141233U (en) * | 1974-05-08 | 1975-11-20 | ||
| CA1083141A (en) * | 1977-03-07 | 1980-08-05 | Lowell D. Hatfield | Cephalosporin displacement reaction |
| NL7805715A (en) * | 1977-06-03 | 1978-12-05 | Hoffmann La Roche | METHOD FOR PREPARING ACYL DERIVATIVES. |
| US4200745A (en) * | 1977-12-20 | 1980-04-29 | Eli Lilly And Company | 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins |
| MC1259A1 (en) * | 1978-05-30 | 1980-01-14 | Hoffmann La Roche | ACYL DERIVATIVES |
| NO782998L (en) * | 1978-07-19 | 1980-01-22 | Hoffmann La Roche | CEPHALOSPORINESTERS AND EATERS. |
| FR2474030A1 (en) * | 1980-01-17 | 1981-07-24 | Rhone Poulenc Ind | 2-Mercapto-1,2,4-triazine, 1,3,4-triazole or tetrazole derivs. - useful as intermediates for antibacterial cephalosporin(s) |
| NL8100089A (en) | 1980-01-17 | 1981-08-17 | Rhone Poulenc Ind | NEW THIOLS AND THEIR PREPARATION. |
| FR2494278A1 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW DERIVATIVES OF CEPHALOSPORIN, THEIR PREPARATIONS AND THE MEDICINAL PRODUCTS CONTAINING THEM |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5116436B1 (en) * | 1971-05-31 | 1976-05-24 |
-
1975
- 1975-07-24 CA CA232,136A patent/CA1100129A/en not_active Expired
- 1975-07-25 IL IL47802A patent/IL47802A/en unknown
- 1975-07-25 CS CS755262A patent/CS189716B2/en unknown
- 1975-07-25 FR FR7523346A patent/FR2280381A1/en active Granted
- 1975-07-25 RO RO7593489A patent/RO72980A/en unknown
- 1975-07-28 SE SE7508570A patent/SE426830B/en not_active IP Right Cessation
- 1975-07-29 IE IE1693/75A patent/IE41590B1/en unknown
- 1975-07-29 DK DK343275A patent/DK343275A/en not_active Application Discontinuation
- 1975-07-29 NL NL7509053A patent/NL7509053A/en not_active Application Discontinuation
- 1975-07-29 JP JP50092486A patent/JPS6123195B2/ja not_active Expired
- 1975-07-29 GB GB31598/75A patent/GB1521073A/en not_active Expired
- 1975-07-29 SU SU752163060A patent/SU755200A3/en active
- 1975-07-30 DE DE19752534071 patent/DE2534071A1/en not_active Withdrawn
- 1975-07-31 AT AT594075A patent/AT347580B/en active
- 1975-07-31 AR AR259862A patent/AR210998A1/en active
- 1975-07-31 CH CH1005975A patent/CH616683A5/en not_active IP Right Cessation
- 1975-08-01 DD DD187628A patent/DD121114A5/xx unknown
- 1975-08-01 HU HU75EI637A patent/HU174130B/en unknown
- 1975-08-01 YU YU01970/75A patent/YU197075A/en unknown
- 1975-08-01 PL PL1975182474A patent/PL95607B1/en unknown
- 1975-08-02 BG BG030722A patent/BG26395A3/en unknown
-
1977
- 1977-08-26 PH PH20172A patent/PH16078A/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4298605A (en) | 1978-06-22 | 1981-11-03 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
| US4301161A (en) | 1978-06-22 | 1981-11-17 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
| US4328224A (en) | 1978-06-22 | 1982-05-04 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
| US4341776A (en) | 1978-06-22 | 1982-07-27 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| SE7508570L (en) | 1976-02-03 |
| AT347580B (en) | 1979-01-10 |
| FR2280381A1 (en) | 1976-02-27 |
| DD121114A5 (en) | 1976-07-12 |
| ATA594075A (en) | 1976-11-15 |
| DE2534071A1 (en) | 1976-02-12 |
| PL95607B1 (en) | 1977-10-31 |
| IL47802A0 (en) | 1975-10-15 |
| SE426830B (en) | 1983-02-14 |
| PH16078A (en) | 1983-06-20 |
| SU755200A3 (en) | 1980-08-07 |
| BG26395A3 (en) | 1979-03-15 |
| JPS6123195B2 (en) | 1986-06-04 |
| NL7509053A (en) | 1976-02-04 |
| RO72980A (en) | 1981-08-30 |
| YU197075A (en) | 1982-05-31 |
| HU174130B (en) | 1979-11-28 |
| FR2280381B1 (en) | 1979-08-10 |
| IE41590L (en) | 1976-02-02 |
| JPS5139693A (en) | 1976-04-02 |
| IL47802A (en) | 1980-05-30 |
| CA1100129A (en) | 1981-04-28 |
| IE41590B1 (en) | 1980-02-13 |
| DK343275A (en) | 1976-02-03 |
| AR210998A1 (en) | 1977-10-14 |
| CS189716B2 (en) | 1979-04-30 |
| CH616683A5 (en) | 1980-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |