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GB1480757A - Preparation of 7-acylamino cephalosporin derivatives - Google Patents

Preparation of 7-acylamino cephalosporin derivatives

Info

Publication number
GB1480757A
GB1480757A GB50969/74A GB5096974A GB1480757A GB 1480757 A GB1480757 A GB 1480757A GB 50969/74 A GB50969/74 A GB 50969/74A GB 5096974 A GB5096974 A GB 5096974A GB 1480757 A GB1480757 A GB 1480757A
Authority
GB
United Kingdom
Prior art keywords
group
preparation
derivative
cephalosporin derivatives
acylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB50969/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1480757A publication Critical patent/GB1480757A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D501/06—Acylation of 7-aminocephalosporanic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Cephem derivatives of the following formula <IMAGE> in which the substituents are defined in Claim 1, are prepared by a novel process. In this process, an appropriate 7-acylamidocephem derivative having a protected carboxyl group in the 4-position is reacted in the presence of a molecular sieve with an acylating agent donating the desired acyl radical. The original acyl group is removed from the initially resulting 7-diacylamidocephem derivative. The free acid is obtained by removal of the protective group R'', which preferably represents an easily removable ester group. The said compounds are used as antibiotics.
GB50969/74A 1973-11-30 1974-11-25 Preparation of 7-acylamino cephalosporin derivatives Expired GB1480757A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42041873A 1973-11-30 1973-11-30
US50747374A 1974-09-23 1974-09-23

Publications (1)

Publication Number Publication Date
GB1480757A true GB1480757A (en) 1977-07-27

Family

ID=27024839

Family Applications (1)

Application Number Title Priority Date Filing Date
GB50969/74A Expired GB1480757A (en) 1973-11-30 1974-11-25 Preparation of 7-acylamino cephalosporin derivatives

Country Status (18)

Country Link
JP (1) JPS6020393B2 (en)
AR (1) AR211234A1 (en)
CA (1) CA1041481A (en)
CH (1) CH618443A5 (en)
DD (1) DD115125A5 (en)
DE (1) DE2456528C2 (en)
DK (1) DK153154C (en)
ES (1) ES432305A1 (en)
FI (1) FI60210C (en)
FR (1) FR2253022B1 (en)
GB (1) GB1480757A (en)
HU (1) HU168823B (en)
IE (1) IE40122B1 (en)
IT (1) IT1043920B (en)
NL (1) NL187023C (en)
NO (1) NO147839C (en)
SE (1) SE432934B (en)
YU (1) YU36736B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56158790A (en) * 1980-05-14 1981-12-07 Sankyo Co Ltd Preparation of cephalosporin derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2127225A1 (en) * 1970-06-12 1971-12-16 Yamanouchi Pharmaceutical Co Ltd , Tokio New process for making cephalexin
US3843639A (en) * 1973-02-08 1974-10-22 Bristol Myers Co Production of cephalexin via methoxymethyl ester

Also Published As

Publication number Publication date
FR2253022B1 (en) 1978-07-07
CH618443A5 (en) 1980-07-31
SE432934B (en) 1984-04-30
NO147839C (en) 1983-06-22
HU168823B (en) 1976-07-28
NL187023C (en) 1991-05-01
FI330174A7 (en) 1975-05-31
ES432305A1 (en) 1977-06-16
IT1043920B (en) 1980-02-29
DE2456528A1 (en) 1975-06-05
FR2253022A1 (en) 1975-06-27
SE7414249L (en) 1975-06-02
NL187023B (en) 1990-12-03
JPS6020393B2 (en) 1985-05-21
IE40122B1 (en) 1979-03-14
YU36736B (en) 1984-08-31
NO744088L (en) 1975-06-23
DK153154B (en) 1988-06-20
CA1041481A (en) 1978-10-31
NL7414820A (en) 1975-06-03
JPS50105687A (en) 1975-08-20
FI60210B (en) 1981-08-31
AR211234A1 (en) 1977-11-15
YU310474A (en) 1981-11-13
NO147839B (en) 1983-03-14
DE2456528C2 (en) 1986-01-16
DK589474A (en) 1975-07-28
FI60210C (en) 1981-12-10
IE40122L (en) 1975-05-30
DK153154C (en) 1988-10-24
DD115125A5 (en) 1975-09-12
AU7550474A (en) 1976-05-20

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years

Effective date: 19941124