GB1421058A - Dibenzocycloheptenyl lactamimides - Google Patents
Dibenzocycloheptenyl lactamimidesInfo
- Publication number
- GB1421058A GB1421058A GB5521273A GB5521273A GB1421058A GB 1421058 A GB1421058 A GB 1421058A GB 5521273 A GB5521273 A GB 5521273A GB 5521273 A GB5521273 A GB 5521273A GB 1421058 A GB1421058 A GB 1421058A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- lactamimides
- dibenzocycloheptenyl
- merrell
- cyclohepten
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KZMGYPLQYOPHEL-UHFFFAOYSA-N Boron trifluoride etherate Chemical compound FB(F)F.CCOCC KZMGYPLQYOPHEL-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KTADHXXSCNRJRT-UHFFFAOYSA-N 6,11-dihydro-5h-dibenzo[1,2-a:1',2'-e][7]annulen-11-amine Chemical compound C1CC2=CC=CC=C2C(N)C2=CC=CC=C21 KTADHXXSCNRJRT-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 150000003951 lactams Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D227/00—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00
- C07D227/02—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D227/06—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D227/10—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1421058 Dibenzocycloheptenyl lactamimides RICHARDSON-MERRELL Inc 28 Nov 1973 [5 Jan 1973] 55212/73 Heading C2C Novel compounds of the Formula (I): wherein n is an integer of from 3 to 11, and pharmaceutically acceptable acid addition salts thereof, may be obtained by reacting 10,11- dihydro - 5H - dibenzo[a,d]cyclohepten - 5- amine with an excess of a lactim ether of the formula where the alkyl may be methyl, ethyl or the like, or with a complex of a corresponding lactam with phosphorous oxychloride, phosgene, boron trifluoride etherate, dimethyl sulphate, hydrogen halide or a combination of two or more of these reagents. Pharmaceutical compositions useful as diuretics, anti-inflammatory agents or anticoagulants, comprise a compound of Formula I, and a pharmaceutical carrier, in forms suitable for oral or parenteral use.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00321288A US3833559A (en) | 1973-01-05 | 1973-01-05 | Dibenzocycloheptenyl lactamimides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1421058A true GB1421058A (en) | 1976-01-14 |
Family
ID=23249975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5521273A Expired GB1421058A (en) | 1973-01-05 | 1973-11-28 | Dibenzocycloheptenyl lactamimides |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3833559A (en) |
| JP (1) | JPS604168B2 (en) |
| AU (1) | AU476386B2 (en) |
| CA (1) | CA1003826A (en) |
| DE (1) | DE2361929A1 (en) |
| FR (1) | FR2213064B1 (en) |
| GB (1) | GB1421058A (en) |
| IL (1) | IL43703A (en) |
| ZA (1) | ZA738703B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5010072A (en) * | 1988-06-28 | 1991-04-23 | Merrell Dow Pharmaceuticals Inc. | Lactamimides as calcium antagonists |
| US5082837A (en) * | 1988-06-28 | 1992-01-21 | Merrell Dow Pharmaceuticals | Lactamimides as calcium antagonists |
| US5198433A (en) * | 1988-06-28 | 1993-03-30 | Merrell Dow Pharmaceuticals Inc. | Lactamimides as calcium antagonists |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA722441B (en) * | 1971-05-13 | 1973-01-31 | Richardson Merrell Inc | 9-fluorenyl lactamimides |
-
1973
- 1973-01-05 US US00321288A patent/US3833559A/en not_active Expired - Lifetime
- 1973-11-13 ZA ZA00738703A patent/ZA738703B/en unknown
- 1973-11-15 AU AU62514/73A patent/AU476386B2/en not_active Expired
- 1973-11-22 CA CA186,440A patent/CA1003826A/en not_active Expired
- 1973-11-26 IL IL43703A patent/IL43703A/en unknown
- 1973-11-28 GB GB5521273A patent/GB1421058A/en not_active Expired
- 1973-12-13 DE DE2361929A patent/DE2361929A1/en not_active Withdrawn
- 1973-12-28 JP JP48144809A patent/JPS604168B2/en not_active Expired
-
1974
- 1974-01-04 FR FR7400316A patent/FR2213064B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS604168B2 (en) | 1985-02-01 |
| FR2213064B1 (en) | 1977-06-03 |
| AU476386B2 (en) | 1976-09-16 |
| AU6251473A (en) | 1975-05-15 |
| FR2213064A1 (en) | 1974-08-02 |
| JPS4995965A (en) | 1974-09-11 |
| US3833559A (en) | 1974-09-03 |
| ZA738703B (en) | 1975-02-26 |
| IL43703A (en) | 1977-07-31 |
| CA1003826A (en) | 1977-01-18 |
| IL43703A0 (en) | 1974-03-14 |
| DE2361929A1 (en) | 1974-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |