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GB1451900A - Quinolin-2-1h-ones - Google Patents

Quinolin-2-1h-ones

Info

Publication number
GB1451900A
GB1451900A GB5030373A GB5030373A GB1451900A GB 1451900 A GB1451900 A GB 1451900A GB 5030373 A GB5030373 A GB 5030373A GB 5030373 A GB5030373 A GB 5030373A GB 1451900 A GB1451900 A GB 1451900A
Authority
GB
United Kingdom
Prior art keywords
alkyl
quinolinones
alkoxy
alkali metal
quinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5030373A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Priority to GB5030373A priority Critical patent/GB1451900A/en
Publication of GB1451900A publication Critical patent/GB1451900A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1451900 Derivatives of 2(1H)quinolinone SANDOZ Ltd 30 Oct 1973 50303/73 Heading C2C The invention comprises compounds of formula and their alkali metal salts (wherein R 3 is H, F, Cl, Br or C 1-4 alkoxy, R<SP>1</SP> 4 is C 1-8 alkyl and R 9 is C 1-4 alkyl), and a process for making them by reacting the corresponding isotoic anhydride with MCH(CO 2 R 9 ) 2 , M being an alkali metal. These compounds may be hydrolysed and decarboxylated, and the thus-formed 1-alkyl-4- hydroxy - 2(1H)quinolinones may be converted to the corresponding ethers. Therapeutic compositions comprise 4-alkoxy-1- alkyl-2(1H)-quinolinones, which are said to have minor tranquillizing activity.
GB5030373A 1973-10-30 1973-10-30 Quinolin-2-1h-ones Expired GB1451900A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB5030373A GB1451900A (en) 1973-10-30 1973-10-30 Quinolin-2-1h-ones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5030373A GB1451900A (en) 1973-10-30 1973-10-30 Quinolin-2-1h-ones

Publications (1)

Publication Number Publication Date
GB1451900A true GB1451900A (en) 1976-10-06

Family

ID=10455416

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5030373A Expired GB1451900A (en) 1973-10-30 1973-10-30 Quinolin-2-1h-ones

Country Status (1)

Country Link
GB (1) GB1451900A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734416A (en) * 1978-03-30 1988-03-29 Otsuka Pharmaceutical Co., Ltd. Pharmaceutically useful carbostyril derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734416A (en) * 1978-03-30 1988-03-29 Otsuka Pharmaceutical Co., Ltd. Pharmaceutically useful carbostyril derivatives
US4824840A (en) * 1978-03-30 1989-04-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and pharmaceutical preparations containing same

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee