GB1334471A - Preparation of urea derivatives - Google Patents
Preparation of urea derivativesInfo
- Publication number
- GB1334471A GB1334471A GB1599772A GB1599772A GB1334471A GB 1334471 A GB1334471 A GB 1334471A GB 1599772 A GB1599772 A GB 1599772A GB 1599772 A GB1599772 A GB 1599772A GB 1334471 A GB1334471 A GB 1334471A
- Authority
- GB
- United Kingdom
- Prior art keywords
- halogen
- alkyl
- preparation
- april
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003672 ureas Chemical class 0.000 title 1
- -1 R<SP>1</SP> is H Inorganic materials 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004945 acylaminoalkyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1334471 Process for making sulphonylureas CHINOIN GYOGYSZER-ES VEGYESZETI TERMEKEK GYARA RT 6 April 1972 [6 April 1971] 15997/72 Heading C2C The invention comprises reacting or its salt with CX 3 -CONHR<SP>2</SP> to give therapeutic compounds (I) (X is halogen, R<SP>1</SP> is H, halogen, C 1 to C 6 alkyl, alkoxy, NH 2 , acylamino or acylaminoalkyl, where acyl is derived from an aliphatic, aromatic or heterocyclic carboxylic acid optionally substituted by halogen, alkyl and/or alkoxy, and R<SP>2</SP> is C 1 to C 6 alkyl or C 4 to C 7 cycloalkyl.)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI001096 HU162761B (en) | 1971-04-06 | 1971-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1334471A true GB1334471A (en) | 1973-10-17 |
Family
ID=10994401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1599772A Expired GB1334471A (en) | 1971-04-06 | 1972-04-06 | Preparation of urea derivatives |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5227149B1 (en) |
| AT (1) | AT315191B (en) |
| CH (1) | CH580070A5 (en) |
| CS (1) | CS166908B1 (en) |
| DD (1) | DD99161A1 (en) |
| DE (1) | DE2213602A1 (en) |
| DK (1) | DK134011B (en) |
| GB (1) | GB1334471A (en) |
| HU (1) | HU162761B (en) |
| NO (1) | NO138139C (en) |
| PL (1) | PL83532B1 (en) |
| SE (1) | SE396600B (en) |
| SU (1) | SU503513A3 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0149592A3 (en) * | 1984-01-19 | 1986-06-04 | Läkemedelsfabriken-Medica Ab | Process for the preparation of a pharmacologically active sulphonylurea derivative |
| CN107434788B (en) * | 2017-09-11 | 2018-06-15 | 威海迪素制药有限公司 | A kind of preparation method of Glipizide |
-
1971
- 1971-04-06 HU HUCI001096 patent/HU162761B/hu unknown
-
1972
- 1972-03-17 AT AT226672A patent/AT315191B/en not_active IP Right Cessation
- 1972-03-21 DE DE19722213602 patent/DE2213602A1/en active Pending
- 1972-03-23 CS CS194472A patent/CS166908B1/cs unknown
- 1972-03-29 SE SE416972A patent/SE396600B/en unknown
- 1972-04-04 CH CH491072A patent/CH580070A5/xx not_active IP Right Cessation
- 1972-04-05 PL PL15456772A patent/PL83532B1/en unknown
- 1972-04-05 DD DD16207772A patent/DD99161A1/xx unknown
- 1972-04-05 NO NO113872A patent/NO138139C/en unknown
- 1972-04-05 JP JP47034331A patent/JPS5227149B1/ja active Pending
- 1972-04-05 DK DK164572A patent/DK134011B/en not_active IP Right Cessation
- 1972-04-05 SU SU1768163A patent/SU503513A3/en active
- 1972-04-06 GB GB1599772A patent/GB1334471A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0149592A3 (en) * | 1984-01-19 | 1986-06-04 | Läkemedelsfabriken-Medica Ab | Process for the preparation of a pharmacologically active sulphonylurea derivative |
| CN107434788B (en) * | 2017-09-11 | 2018-06-15 | 威海迪素制药有限公司 | A kind of preparation method of Glipizide |
Also Published As
| Publication number | Publication date |
|---|---|
| PL83532B1 (en) | 1975-12-31 |
| NO138139C (en) | 1978-07-12 |
| DK134011B (en) | 1976-08-30 |
| DD99161A1 (en) | 1973-07-20 |
| SE396600B (en) | 1977-09-26 |
| SU503513A3 (en) | 1976-02-15 |
| JPS5227149B1 (en) | 1977-07-19 |
| NO138139B (en) | 1978-04-03 |
| CS166908B1 (en) | 1976-03-29 |
| DE2213602A1 (en) | 1972-10-12 |
| CH580070A5 (en) | 1976-09-30 |
| AT315191B (en) | 1974-05-10 |
| DK134011C (en) | 1977-01-31 |
| HU162761B (en) | 1973-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 435 | Patent endorsed 'licences of right' on the date specified (sect. 35/1949) | ||
| PCNP | Patent ceased through non-payment of renewal fee |