GB1334271A - Diazabicycloundecapentene derivative - Google Patents
Diazabicycloundecapentene derivativeInfo
- Publication number
- GB1334271A GB1334271A GB1404571*[A GB1404571A GB1334271A GB 1334271 A GB1334271 A GB 1334271A GB 1404571 A GB1404571 A GB 1404571A GB 1334271 A GB1334271 A GB 1334271A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrazine
- acid
- reaction
- derivative
- hydrazine hydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LGJQBONKYIQKQS-UHFFFAOYSA-N 3-cycloundeca-1,3,5,7,9-pentaen-1-yl-1,2-diazacycloundeca-2,5,7,9,11-pentaene Chemical class C1(=NN=CC=CC=CC=CC1)C1=CC=CC=CC=CC=CC1 LGJQBONKYIQKQS-UHFFFAOYSA-N 0.000 title 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 4
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- ZWUMDFWFKWDFBI-UHFFFAOYSA-N 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]pentan-2-one Chemical compound CCC(C(C)=O)C1=CC(OC)=C(OC)C=C1C(=O)C1=CC=C(OC)C(OC)=C1 ZWUMDFWFKWDFBI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1334271 Diazabicycloundecapentane derivative E GY T GYOGYSZERVEGYESZETI GYAR 10 May 1971 [6 Nov 1970] 14045/71 Heading C2C The novel compound I and acid addition salts thereof are prepared (1) by reaction of compounds II with hydrazine or hydrazine hydrate to give compounds III and reacting compounds III with an acid, (2) by reaction of a 1-veratryl-3-methyl-4-ethyl- 6,7 - dimethoxy - isobenzopyrilium salt with hydrazine or hydrazine hydrate, followed by treatment with an acid or (3) by reaction of 3 - (2 - veratroyl - 4,5 - dimethoxyphenyl)- pentan-2-one with hydrazine or hydrazine hydrate in a mixture of one or more 1-4C alcohols and benzene to give an adduct IV which is then decomposed with an acid. Pharmaceutical compositions comprise a compound I together with a suitable excipient and are useful as tranquillizers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUEE001861 | 1970-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1334271A true GB1334271A (en) | 1973-10-17 |
Family
ID=10995350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1404571*[A Expired GB1334271A (en) | 1970-11-06 | 1971-05-10 | Diazabicycloundecapentene derivative |
Country Status (13)
| Country | Link |
|---|---|
| AT (2) | AT311982B (en) |
| BE (1) | BE769080A (en) |
| DE (1) | DE2122070A1 (en) |
| ES (1) | ES392378A1 (en) |
| GB (1) | GB1334271A (en) |
| HK (1) | HK27776A (en) |
| IL (1) | IL36777A0 (en) |
| NL (1) | NL7108994A (en) |
| PH (1) | PH9942A (en) |
| PL (1) | PL71111B1 (en) |
| SE (1) | SE368206B (en) |
| YU (1) | YU40626B (en) |
| ZA (1) | ZA712798B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2439189A1 (en) * | 1978-10-19 | 1980-05-16 | Egyt Gyogyszervegyeszeti Gyar | NOVEL 5H-2,3-BENZODIAZEPINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| WO2009156776A1 (en) * | 2008-06-27 | 2009-12-30 | Egis Gyogyszergyar Nyilvanosan Müködö | Process for the preparation of high purity 1-(3,4-dimethoxy-phenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-2,3-benzodiazepine |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE269705T1 (en) * | 1998-10-27 | 2004-07-15 | Vela Pharmaceuticals Inc | USE OF OPTICALLY PURE (R)-TOFIZOPAM FOR THE TREATMENT AND PREVENTION OF ANXIETY DISORDERS |
| US6649607B2 (en) | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures |
| CZ2004792A3 (en) * | 2001-12-13 | 2004-12-15 | EGIS Gyógyszergyár Rt. | Process for preparing pharmaceutical intermediates |
-
1971
- 1971-04-30 ZA ZA712798A patent/ZA712798B/en unknown
- 1971-05-03 SE SE05722/71A patent/SE368206B/xx unknown
- 1971-05-03 PL PL1971147922A patent/PL71111B1/pl unknown
- 1971-05-04 IL IL36777A patent/IL36777A0/en unknown
- 1971-05-04 DE DE19712122070 patent/DE2122070A1/en active Pending
- 1971-05-05 YU YU1122/71A patent/YU40626B/en unknown
- 1971-05-05 AT AT869372A patent/AT311982B/en not_active IP Right Cessation
- 1971-05-05 AT AT393871A patent/AT310171B/en not_active IP Right Cessation
- 1971-05-10 GB GB1404571*[A patent/GB1334271A/en not_active Expired
- 1971-06-17 ES ES392378A patent/ES392378A1/en not_active Expired
- 1971-06-25 BE BE769080A patent/BE769080A/en not_active IP Right Cessation
- 1971-06-29 NL NL7108994A patent/NL7108994A/xx unknown
- 1971-10-29 PH PH12979A patent/PH9942A/en unknown
-
1976
- 1976-05-13 HK HK277/76*UA patent/HK27776A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2439189A1 (en) * | 1978-10-19 | 1980-05-16 | Egyt Gyogyszervegyeszeti Gyar | NOVEL 5H-2,3-BENZODIAZEPINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| WO2009156776A1 (en) * | 2008-06-27 | 2009-12-30 | Egis Gyogyszergyar Nyilvanosan Müködö | Process for the preparation of high purity 1-(3,4-dimethoxy-phenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5h-2,3-benzodiazepine |
Also Published As
| Publication number | Publication date |
|---|---|
| ES392378A1 (en) | 1973-09-16 |
| HK27776A (en) | 1976-05-21 |
| SE368206B (en) | 1974-06-24 |
| ZA712798B (en) | 1972-02-23 |
| AT311982B (en) | 1973-12-10 |
| IL36777A0 (en) | 1971-07-28 |
| YU112271A (en) | 1984-02-29 |
| DE2122070A1 (en) | 1972-06-08 |
| NL7108994A (en) | 1972-05-09 |
| PH9942A (en) | 1976-06-14 |
| YU40626B (en) | 1986-04-30 |
| BE769080A (en) | 1971-11-03 |
| AT310171B (en) | 1973-09-25 |
| PL71111B1 (en) | 1974-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1211811A (en) | Process for the preparation of polyurethanes | |
| ES267248A1 (en) | Pyrazolo-pyrimidines and process for preparing same | |
| GB1367677A (en) | Optically active basically substituted phenylacetonitriles | |
| GB1394416A (en) | Cyclopropanecarboxylates processes for producing them and compositions containing them | |
| GB1334271A (en) | Diazabicycloundecapentene derivative | |
| GB1373548A (en) | Anti-hypertensive 6-substituted 3-hydrazino-pyridazines and their preparation | |
| GB1204922A (en) | 03-alkyl-9,10-seco-gonatetraenes and processes for their preparation | |
| GB1369795A (en) | Process for preparing methacrylate esters of phenol derivatives | |
| GB1351467A (en) | Alicyclic diketones and process for their manufacture | |
| GB1162835A (en) | Improvements in or relating to Isoindole Compounds | |
| GB1128079A (en) | Process for the manufacture of new cyclohexane derivatives | |
| GB1276589A (en) | 0-alkyl-6-azauracil compounds and compositions containing the same | |
| GB1225019A (en) | Sulphonic acid esters | |
| GB1283632A (en) | Phenylethanolamine derivatives | |
| GB1201977A (en) | Penicilloic acid derivatives and a process for the manufacture thereof | |
| GB1341204A (en) | Process for the manufacture of triarylmethane compounds | |
| GB1466571A (en) | Substituted quinazolone compounds and pharmaceutical uses thereof | |
| GB1351358A (en) | Method of making benzoxazines | |
| GB1292846A (en) | A process for the synthesis of leupeptins and their analogues | |
| GB1257270A (en) | ||
| GB1150614A (en) | Pyrylium Compounds | |
| GB1199758A (en) | Arylsulphonyl-Semicarbazides and their production | |
| GB1368487A (en) | /pyrazolo/3,4-b/pyridin-5-yl-form-amidoethyl//phenyl-su lphonylureas | |
| GB1412045A (en) | ||
| GB1350309A (en) | Acetylsalicylic acid derivative method for its preparation and therapeutic composition containing same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |