[go: up one dir, main page]

GB1292846A - A process for the synthesis of leupeptins and their analogues - Google Patents

A process for the synthesis of leupeptins and their analogues

Info

Publication number
GB1292846A
GB1292846A GB54834/69A GB5483469A GB1292846A GB 1292846 A GB1292846 A GB 1292846A GB 54834/69 A GB54834/69 A GB 54834/69A GB 5483469 A GB5483469 A GB 5483469A GB 1292846 A GB1292846 A GB 1292846A
Authority
GB
United Kingdom
Prior art keywords
leu
arg
ome
nov
leupeptins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB54834/69A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of GB1292846A publication Critical patent/GB1292846A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

1292846 Leupeptins ZAIDAN HOJIN BISEIBUTSU KAGAKO KENKYU KAI 10 Nov 1969 [21 Nov 1968 30 Nov 1968 11 June 1969] 54834/69 Heading C2C Compounds (I) (wherein n is 1 or 0; R 3 is Me or Et and R 1 and R 2 are CHMe 2 , CH 2 CHMe 2 or CH(Me)(Et) are prepared by reducing a compound (II) with a metal hydride at room temperature to 150‹ C. to give a compound (III) and oxidizing this with sulphoxide-carbodiimide at room temperature, or by reacting (II) with thionyl chloride to give the acid chloride and reducing this with hydrogen in the presence of a hydrogenation catalyst at 120-30‹ C: The following starting materials were prepared: Z-Leu-Leu-OEt, and -OH, Z-Leu-Leu- Arg(NO 2 )OMe, H - Leu - Leu - Arg - OMediHOAc, Ac - Leu - Leu - ArgOMe and - OH; Pr - Leu - Leu - ArgOH; Ac - Leu - Leu - ArgCl, HCl; Z - Leu - Arg(NO 2 )OMe, HLeu - Arg- OMediHOAc, and Ac - Leu - Arg - OMe and -OH.
GB54834/69A 1968-11-21 1969-11-10 A process for the synthesis of leupeptins and their analogues Expired GB1292846A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8482468 1968-11-21
JP8729268 1968-11-30
JP4536969 1969-06-11

Publications (1)

Publication Number Publication Date
GB1292846A true GB1292846A (en) 1972-10-11

Family

ID=27292208

Family Applications (1)

Application Number Title Priority Date Filing Date
GB54834/69A Expired GB1292846A (en) 1968-11-21 1969-11-10 A process for the synthesis of leupeptins and their analogues

Country Status (8)

Country Link
BE (1) BE742067A (en)
CH (1) CH534131A (en)
DE (1) DE1958383C3 (en)
DK (1) DK146320C (en)
FR (1) FR2023831B1 (en)
GB (1) GB1292846A (en)
NL (1) NL166923C (en)
SE (1) SE369074B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5754157A (en) * 1980-09-19 1982-03-31 Nippon Kayaku Co Ltd L-argininal derivative and its preparation
JP2701932B2 (en) * 1989-04-10 1998-01-21 サントリー株式会社 Protease inhibitor
DE4207479C2 (en) * 1992-03-10 1994-11-17 Goetze Ag Shaft sealing ring for sealing a split housing

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268212A (en) * 1968-04-19 1972-03-22 Zaidan Hojin Biseibutsu Tripeptide derivatives

Also Published As

Publication number Publication date
DE1958383B2 (en) 1974-05-22
NL166923C (en) 1981-10-15
NL6917470A (en) 1970-05-25
DE1958383C3 (en) 1974-12-19
SE369074B (en) 1974-08-05
NL166923B (en) 1981-05-15
BE742067A (en) 1970-05-04
FR2023831B1 (en) 1974-01-11
DK146320B (en) 1983-09-05
CH534131A (en) 1973-02-28
DK146320C (en) 1984-02-20
DE1958383A1 (en) 1970-06-04
FR2023831A1 (en) 1970-08-21

Similar Documents

Publication Publication Date Title
GB1292846A (en) A process for the synthesis of leupeptins and their analogues
GB1213558A (en) Process for the production of 1,1-dihydroperfluoroalkanols
GB1500646A (en) Process for producing oxygen-containing cyclic fluoro compounds
GB1444565A (en) Process for conversion of alkyl transchrysantemates in admixture with alkyl cis-chrysanthemates to the corresponding acid
GB1311408A (en) Process for the preparation of butyrolactones
GB1060256A (en) Process for the production of choline chloride
GB1358948A (en) Process for the manufacture of cycloalkenone esters
GB1340370A (en) Process for the purification of o-hydroxydiphenyl
GB1453768A (en) Process for the production of hydroxydiphenyl
GB1276774A (en) Process for the preparation of isocyanates
GB1309670A (en) Pyranosides
GB1443310A (en) Process for the production of neohesperidine dihydrochalcone
GB1310382A (en) Process for the preparation of glucofuranosides
GB1129209A (en) Tricyclic n-alkylated derivatives of acetamide
GB1184709A (en) Process for the preparation of Pyrazinoyl- and Pyrazinamido-Guanidines
GB1301367A (en)
GB1325156A (en) V-triazoles
ES479628A1 (en) Process for preparing p-chlorophenoxy-acetyl-piperonylpiperazine hydrochloride
GB1489374A (en) Process for the manufacture of ethynyl carbinols
GB1314120A (en) Process for the production of anthraquinone-alpha-sulphonic acid
JPS5373529A (en) Preparation of hydroquinone
GB1232753A (en)
GB1315377A (en) Solid fire-extinguishing compositions
GB1142331A (en) A process for producing 2-substituted-cyclopentane-1,3-diones
ES447297A1 (en) Process for the preparation of N-acetoacetyl-2,5-dimethoxy-4-chloroanilide

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee