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GB1329590A - Amino-oxy carboxylic acid amides - Google Patents

Amino-oxy carboxylic acid amides

Info

Publication number
GB1329590A
GB1329590A GB6117770A GB6117770A GB1329590A GB 1329590 A GB1329590 A GB 1329590A GB 6117770 A GB6117770 A GB 6117770A GB 6117770 A GB6117770 A GB 6117770A GB 1329590 A GB1329590 A GB 1329590A
Authority
GB
United Kingdom
Prior art keywords
amino
formula
compounds
oxy
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6117770A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Nyrt
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Nyrt
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt, Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Nyrt
Publication of GB1329590A publication Critical patent/GB1329590A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1329590 Amino-oxy carboxylic acid amides RICHTER GEDEON VEGYESZETI GYAR RT 23 Dec 1970 [29 Dec 1969] 61177/70 Heading C2C [Also in Division A5] The invention comprises amino-oxy carboxylic acid amides of the Formula I wherein X is H or a carboxylic acyl group, R is H or an unsubstituted or substituted alkyl, aralkyl or aryl, and Z is an unsubstituted or substituted C 1-15 alkyl, cycloalkyl, aryl, aralkyl or heterocyclic radical, provided that X is not benzoyl when R is H, the pharmaceutically acceptable acid addition salts of those compounds capable of forming them, and/or the optically active isomers of such compounds containing asymmetric carbon atoms and their preparation and the preparation of compounds of the above Formula I in which X is benzoyl and R is H. The compounds are prepared by reacting compounds of the Formula II or reactive derivatives thereof, wherein A is a carboxylic acyl group, or when in the end product X is H, A is a radical capable of temporarily protecting the amino group, with amines of the formula and, if present, removing the protecting group from the resulting amides of the formula and, if desired, acylating the compounds of Formula I thus obtained in which X is H. N - (Benzyloxycarbonylglycyl)amino-oxyacetanilide is obtained by reacting amino-oxyacetanilide hydrochloride with benzyloxycarbonylglycine pentachlorophenyl ester. 2 - Benzyloxycarbonylamino-oxyacetyl chloride is made by treating the corresponding free acid with phosphorus pentachloride. 2 - Amino-oxy - 6 - benzyloxycarbonylaminohexanilide is prepared by reacting aniline with 2 - amino-oxy-6-benzyloxycarbonylhexanoic acid resulting from the hydrolysis of the corresponding dicyclohexylammonium salt.
GB6117770A 1969-12-29 1970-12-23 Amino-oxy carboxylic acid amides Expired GB1329590A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI385A HU162469B (en) 1969-12-29 1969-12-29

Publications (1)

Publication Number Publication Date
GB1329590A true GB1329590A (en) 1973-09-12

Family

ID=11000834

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6117770A Expired GB1329590A (en) 1969-12-29 1970-12-23 Amino-oxy carboxylic acid amides

Country Status (16)

Country Link
JP (1) JPS4928740B1 (en)
AT (1) AT305242B (en)
BE (1) BE760793A (en)
CA (1) CA952113A (en)
CH (1) CH561177A5 (en)
DE (1) DE2064061C3 (en)
ES (1) ES386847A1 (en)
FI (1) FI53815C (en)
FR (1) FR2081405B1 (en)
GB (1) GB1329590A (en)
HU (1) HU162469B (en)
IL (1) IL35932A (en)
NL (1) NL7018971A (en)
NO (1) NO132393C (en)
SE (1) SE370230B (en)
YU (1) YU34514B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52134132A (en) * 1976-05-06 1977-11-10 Hitachi Ltd Controlling system for automatic burner
JPS59134740U (en) * 1983-02-23 1984-09-08 三国工業株式会社 Combustion control safety circuit
JP5583592B2 (en) 2007-11-30 2014-09-03 ニューリンク ジェネティクス コーポレイション IDO inhibitor
JP5196448B2 (en) * 2007-12-21 2013-05-15 独立行政法人産業技術総合研究所 Reactive compounds containing aminooxy groups

Also Published As

Publication number Publication date
BE760793A (en) 1971-05-27
DE2064061A1 (en) 1971-07-15
CH561177A5 (en) 1975-04-30
JPS4928740B1 (en) 1974-07-29
DE2064061B2 (en) 1973-10-18
NO132393B (en) 1975-07-28
YU34514B (en) 1979-09-10
IL35932A (en) 1974-11-29
FR2081405A1 (en) 1971-12-03
DE2064061C3 (en) 1974-05-22
ES386847A1 (en) 1973-04-01
SE370230B (en) 1974-10-07
IL35932A0 (en) 1971-02-25
FI53815C (en) 1978-08-10
NL7018971A (en) 1971-07-01
AT305242B (en) 1973-02-12
CA952113A (en) 1974-07-30
FI53815B (en) 1978-05-02
YU318770A (en) 1979-02-28
FR2081405B1 (en) 1974-07-12
HU162469B (en) 1973-02-28
NO132393C (en) 1975-11-05

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee