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GB1251069A - - Google Patents

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Publication number
GB1251069A
GB1251069A GB1251069DA GB1251069A GB 1251069 A GB1251069 A GB 1251069A GB 1251069D A GB1251069D A GB 1251069DA GB 1251069 A GB1251069 A GB 1251069A
Authority
GB
United Kingdom
Prior art keywords
group
sulphur
replaced
compound
hydroxyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH168A external-priority patent/CH511890A/en
Application filed filed Critical
Publication of GB1251069A publication Critical patent/GB1251069A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Fodder In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,251,069. Acylamino compounds. CIBAGEIGY A.G. 30 Dec., 1968 [2 Jan., 1968; 13 Sept., 1968], No. 61556/68. Heading C2A. Derivatives of 7-aminocephalosporanic acids having the general formula wherein R 1 represents a heterocyclic radical of formula which may be unsaturated or partially or fully saturated, in which X and Y, which may be the same or different, each represents a nitrogen, oxygen or sulphur atom, and W and Z, which may be the same or different, each represents a carbon, nitrogen, oxygen or sulphur atom, which heterocyclic radical may, where possible, be substituted in the 5-position by a mercapto group and in one or more of the other positions by a hydroxyl or lower alkyl or alkoxy group having 1-5 carbon atoms, and R 2 represents a free hydroxyl group or a hydroxyl group esterified by a carboxylic acid in which ester group oxygen atoms may be replaced by sulphur atoms, an optionallyN-substituted carbamoyloxy group in which oxygen atoms may be replaced by sulphur, or a quaternary amino group, or a salt thereof, are prepared by (a) reacting of compound of general formula in which Z represents halogenacetyl, with a mercapto compound of formula R 1 -SH or (b) acylating a compound of Formula III, in which Z stands for H, with the group and, if desired, a resulting compound containing a free hydroxyl group R 2 or a hydroxyl group esterified with a carboxylic acid is converted one into the other and, if desired, in a resulting compound in which R 2 is a hydroxyl group esterified with a carboxylic acid, in which ester group oxygen atoms may be replaced by sulphur, this group is replaced in known manner by a possibly N-substituted carbamoyloxy group in which oxygen atoms may be replaced by sulphur or by a quaternary ammonium group and, if desired, the resulting compound is converted into a salt. The starting material 3-(desacetoxymethyl} - 3 - benzoyl - thiomethyl - 7 - bromoacetylaminoceohalosporanic acid is prepared by adding a solution of 3-(desacetoxymethyl)-3-benzoylthiomethyl - 7 - amino - cephalosporanic acid and triethylamine in D.M.F. to a solution of bromoacetylbromide in methylene chloride. Pharmaceutical compositions comprise a compound of general Formula I in admixture or conjunction with a pharmaceutical excipient suitable for enteral, local or parenteral administration. Various suitable excipients and physical forms are specified.
GB1251069D 1968-01-02 1968-12-30 Expired GB1251069A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH168A CH511890A (en) 1968-01-02 1968-01-02 (A) 7-Aminocephalosporanic acid derivs. R1 = heterocyclyl with min. 2 hetero-atoms bound to the S-atom of the mercaptoacetyl group by a C-atom directly between
CH1375068 1968-09-13

Publications (1)

Publication Number Publication Date
GB1251069A true GB1251069A (en) 1971-10-27

Family

ID=25683226

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1251069D Expired GB1251069A (en) 1968-01-02 1968-12-30

Country Status (8)

Country Link
JP (1) JPS4920320B1 (en)
BE (1) BE726315A (en)
BR (1) BR6905283D0 (en)
DE (1) DE1816824A1 (en)
FR (2) FR1601149A (en)
GB (1) GB1251069A (en)
NL (1) NL6818867A (en)
SE (1) SE359095B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068403A3 (en) * 1981-06-24 1984-06-13 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compound

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758219A (en) * 1969-10-30 1971-04-29 Bristol Myers Co ANTIBACTERIAL AGENTS AND METHOD FOR PREPARING THEM
HU188874B (en) * 1983-04-19 1986-05-28 Biogal Gyogyszergyar,Hu Process for producing new 7-acylamido-3-acylaminomethyl-ceph-3-eme-4-carboxylic acid derivatives and pharmaceutically acceptable salts thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068403A3 (en) * 1981-06-24 1984-06-13 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compound

Also Published As

Publication number Publication date
SE359095B (en) 1973-08-20
BE726315A (en) 1969-06-30
FR8259M (en) 1970-10-19
DE1816824A1 (en) 1969-07-31
NL6818867A (en) 1969-07-04
FR1601149A (en) 1970-08-10
JPS4920320B1 (en) 1974-05-23
BR6905283D0 (en) 1973-02-13

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees