GB1316361A - 5h-dibenzazepines - Google Patents
5h-dibenzazepinesInfo
- Publication number
- GB1316361A GB1316361A GB2587770A GB2587770A GB1316361A GB 1316361 A GB1316361 A GB 1316361A GB 2587770 A GB2587770 A GB 2587770A GB 2587770 A GB2587770 A GB 2587770A GB 1316361 A GB1316361 A GB 1316361A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- alkyl
- formula
- alkyl group
- dibenzazepines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VIQDTRXYTKXIMM-UHFFFAOYSA-N 5h-benzo[d][1]benzazepine Chemical class N1C=CC2=CC=CC=C2C2=CC=CC=C12 VIQDTRXYTKXIMM-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 7
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- -1 cyanogen halide Chemical class 0.000 abstract 1
- JMANVNJQNLATNU-UHFFFAOYSA-N glycolonitrile Natural products N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000009877 rendering Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
1316361 Aminoalkyl-dibenzazepines ROUSSEL UCLAF 28 May 1970 [28 May 1969] 25877/70 Heading C2C The invention comprises compounds of the formula wherein R 1 is a C 1 -C 4 alkyl group, R 2 is H or a C 1 -C 4 alkyl group, and X and X<SP>1</SP> are each H or halogen; and acid addition salts thereof. Compounds in which R 2 is alkyl may be obtained by dehydrating a compound of the formula Compounds in which R 2 is H may be obtained by reacting compounds in which R 2 is alkyl with a C 1 -C 4 alkylchloroformate or a cyanogen halide, and rendering alkaline the resulting reaction mixture. Examples are given for the preparation of the compounds. The above compounds may be used in pharmaceutical compositions. The compositions may be administered orally, transcutaneously or rectally and have thymoanaleptic action. The salts are derived from mineral and organic acids. The starting materials and intermediates formed in the above processes are described in Specifications 1,316,362, 1,316,363 and 1,316,364.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR696917373A FR2043486B1 (en) | 1969-05-28 | 1969-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1316361A true GB1316361A (en) | 1973-05-09 |
Family
ID=9034702
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5298272A Expired GB1316364A (en) | 1969-05-28 | 1970-05-28 | 5h-dibenz-b,f-azepine derivatives and the preparation thereof |
| GB2587770A Expired GB1316361A (en) | 1969-05-28 | 1970-05-28 | 5h-dibenzazepines |
| GB5298172A Expired GB1316363A (en) | 1969-05-28 | 1970-05-28 | Alkoxycarbonyl-acridan derivatives and the preparation thereof |
| GB5298072A Expired GB1316362A (en) | 1969-05-28 | 1970-11-06 | Aminoalky-acridan compounds and the preparation thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5298272A Expired GB1316364A (en) | 1969-05-28 | 1970-05-28 | 5h-dibenz-b,f-azepine derivatives and the preparation thereof |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5298172A Expired GB1316363A (en) | 1969-05-28 | 1970-05-28 | Alkoxycarbonyl-acridan derivatives and the preparation thereof |
| GB5298072A Expired GB1316362A (en) | 1969-05-28 | 1970-11-06 | Aminoalky-acridan compounds and the preparation thereof |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS4939274B1 (en) |
| CH (2) | CH527197A (en) |
| DE (1) | DE2026080C3 (en) |
| DK (1) | DK133979B (en) |
| FR (1) | FR2043486B1 (en) |
| GB (4) | GB1316364A (en) |
| IL (1) | IL34546A (en) |
| NL (1) | NL168831C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH533117A (en) * | 1970-05-13 | 1973-01-31 | Ciba Geigy Ag | Process for the production of azepine derivatives |
| FR2201884B1 (en) * | 1972-10-09 | 1975-11-28 | Roussel Uclaf | |
| DE3279029D1 (en) * | 1981-12-11 | 1988-10-20 | Welsh Nat School Med | Luminescent labelling materials and procedures |
| DE3844954C2 (en) * | 1988-02-20 | 1998-07-16 | Hoechst Ag | Special chemiluminescent acridine derivatives and their use in luminescent immunoassays |
| US6002007A (en) * | 1988-02-20 | 1999-12-14 | Dade Behring Marburg Gmbh | Special chemiluminescent acridine derivatives and the use thereof in luminescence immunoassays |
| EP0522677B1 (en) * | 1991-07-10 | 1996-12-18 | TDK Corporation | Method of measuring concentration of immunoreactant using electrochemiluminescence |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH414643A (en) * | 1962-12-04 | 1966-06-15 | Geigy Ag J R | Process for the production of new azepine derivatives |
-
1969
- 1969-05-28 FR FR696917373A patent/FR2043486B1/fr not_active Expired
-
1970
- 1970-05-18 IL IL34546A patent/IL34546A/en unknown
- 1970-05-26 CH CH790570A patent/CH527197A/en not_active IP Right Cessation
- 1970-05-27 NL NLAANVRAGE7007625,A patent/NL168831C/en not_active IP Right Cessation
- 1970-05-27 DE DE2026080A patent/DE2026080C3/en not_active Expired
- 1970-05-28 GB GB5298272A patent/GB1316364A/en not_active Expired
- 1970-05-28 CH CH1166471A patent/CH553785A/en not_active IP Right Cessation
- 1970-05-28 JP JP45045272A patent/JPS4939274B1/ja active Pending
- 1970-05-28 GB GB2587770A patent/GB1316361A/en not_active Expired
- 1970-05-28 DK DK272870AA patent/DK133979B/en unknown
- 1970-05-28 GB GB5298172A patent/GB1316363A/en not_active Expired
- 1970-11-06 GB GB5298072A patent/GB1316362A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1316363A (en) | 1973-05-09 |
| FR2043486B1 (en) | 1973-07-13 |
| DE2026080A1 (en) | 1970-12-03 |
| NL168831C (en) | 1982-05-17 |
| IL34546A (en) | 1974-06-30 |
| NL168831B (en) | 1981-12-16 |
| CH553785A (en) | 1974-09-13 |
| NL7007625A (en) | 1970-12-01 |
| IL34546A0 (en) | 1970-07-19 |
| JPS4939274B1 (en) | 1974-10-24 |
| GB1316362A (en) | 1973-05-09 |
| DK133979B (en) | 1976-08-23 |
| DE2026080B2 (en) | 1979-03-22 |
| DK133979C (en) | 1977-01-31 |
| FR2043486A1 (en) | 1971-02-19 |
| CH527197A (en) | 1972-08-31 |
| GB1316364A (en) | 1973-05-09 |
| DE2026080C3 (en) | 1979-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |