GB1300998A - Improvements in or relating to effervescent antibiotic compositions - Google Patents
Improvements in or relating to effervescent antibiotic compositionsInfo
- Publication number
- GB1300998A GB1300998A GB07419/70A GB1741970A GB1300998A GB 1300998 A GB1300998 A GB 1300998A GB 07419/70 A GB07419/70 A GB 07419/70A GB 1741970 A GB1741970 A GB 1741970A GB 1300998 A GB1300998 A GB 1300998A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotic
- effervescent
- compositions
- acid
- bicarbonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 108010078777 Colistin Proteins 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 abstract 1
- YJQPYGGHQPGBLI-UHFFFAOYSA-N Novobiocin Chemical class O1C(C)(C)C(OC)C(OC(N)=O)C(O)C1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-UHFFFAOYSA-N 0.000 abstract 1
- 229930195708 Penicillin V Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960000723 ampicillin Drugs 0.000 abstract 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical class C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 229960003326 cloxacillin Drugs 0.000 abstract 1
- LQOLIRLGBULYKD-JKIFEVAISA-N cloxacillin Chemical class N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl LQOLIRLGBULYKD-JKIFEVAISA-N 0.000 abstract 1
- 229960003346 colistin Drugs 0.000 abstract 1
- 229960004675 fusidic acid Drugs 0.000 abstract 1
- IECPWNUMDGFDKC-MZJAQBGESA-N fusidic acid Chemical class O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 abstract 1
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 abstract 1
- 229960002950 novobiocin Drugs 0.000 abstract 1
- YJQPYGGHQPGBLI-KGSXXDOSSA-N novobiocin Chemical class O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 229960001019 oxacillin Drugs 0.000 abstract 1
- UWYHMGVUTGAWSP-JKIFEVAISA-N oxacillin Chemical class N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 abstract 1
- 229940056367 penicillin v Drugs 0.000 abstract 1
- NONJJLVGHLVQQM-JHXYUMNGSA-N phenethicillin Chemical class N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(C)OC1=CC=CC=C1 NONJJLVGHLVQQM-JHXYUMNGSA-N 0.000 abstract 1
- 229960004894 pheneticillin Drugs 0.000 abstract 1
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical class N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 abstract 1
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 abstract 1
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 abstract 1
- 159000000001 potassium salts Chemical class 0.000 abstract 1
- 229960003672 propicillin Drugs 0.000 abstract 1
- HOCWPKXKMNXINF-XQERAMJGSA-N propicillin Chemical class N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(CC)OC1=CC=CC=C1 HOCWPKXKMNXINF-XQERAMJGSA-N 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1300998 Effervescent antibiotic compositions BIOCHEMIE GmbH 13 April 1970 [2 May 1969] 17419/70 Heading A5B Effervescent compositions comprise a carbonate or bicarbonate of particle size 50 to 500Ám, an organic acid (e.g. citric or tartaric) of particle size 200 to 1000 Ám and an antibiotic. The weight ratio of carbonate or bicarbonate to acid is in the range 1:1 to 2.0:0.5, that of antibiotic to effervescent couple being from 1:5.5 to 1:15. Specified antibiotics are the sodium and potassium salts of ampicillin, cloxacillin, oxacillin, phenethicillin, phenoxymethyl penicillin, propicillin, novobiocin, fusidinic acid, chloramphenical leucine carbamate and colistin methane sulphonate. The compositions are stated to dissolve with effervescence to give clear, stable solutions, the pH being maintained within the range in which the antibiotic is stable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT426369A AT307616B (en) | 1969-05-02 | 1969-05-02 | Process for making an effervescent preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1300998A true GB1300998A (en) | 1972-12-29 |
Family
ID=3561735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB07419/70A Expired GB1300998A (en) | 1969-05-02 | 1970-04-13 | Improvements in or relating to effervescent antibiotic compositions |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS4838844B1 (en) |
| AT (1) | AT307616B (en) |
| AU (1) | AU1456470A (en) |
| BE (1) | BE749864A (en) |
| DE (1) | DE2020893A1 (en) |
| FR (1) | FR2043500B1 (en) |
| GB (1) | GB1300998A (en) |
| IL (1) | IL34417A (en) |
| NL (1) | NL7006040A (en) |
| ZA (1) | ZA702964B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2532849A1 (en) * | 1982-09-10 | 1984-03-16 | Glaxo Group Ltd | SOLID PHARMACEUTICAL COMPOSITION CONTAINING B-LACTAMIC ANTIBIOTICS, PROCESS FOR PREPARING THE SAME AND METHOD FOR STABILIZING A PHARMACEUTICAL COMPOSITION |
| WO1991016893A1 (en) | 1990-04-27 | 1991-11-14 | Beecham Group Plc | Pharmaceutical formulation |
| US5223246A (en) * | 1990-02-14 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
| US5670170A (en) * | 1990-04-27 | 1997-09-23 | Beecham Group P.L.C. | Pharamaceutical formulation |
| US5814337A (en) * | 1992-10-07 | 1998-09-29 | Beecham Group Plc | Pharmaceutical formulation |
| US6488961B1 (en) | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
| WO2014174405A1 (en) * | 2013-04-22 | 2014-10-30 | Webb Johannes Arnoldus Vosloo | Pharmaceutical preparation |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4289751A (en) * | 1979-06-29 | 1981-09-15 | Merck & Co., Inc. | Effervescent enteric-coated formulation of soluble form of erythromycin and therapeutic use thereof |
| US4678661A (en) * | 1983-09-28 | 1987-07-07 | Gerhard Gergely | Effervescent composition and method of making same |
| FR2593065B1 (en) * | 1986-01-22 | 1988-09-09 | Smith Kline French Lab | EFFERVESCENT COUPLES, EFFERVESCENT COMPOSITIONS OF HISTAMINE H2 ANTAGONISTS CONTAINING THEM AND THEIR PREPARATION. |
| US5064656A (en) * | 1989-11-14 | 1991-11-12 | Dr. Gergely & Co. | Uncoated pharmaceutical reaction tablet |
| GB9007945D0 (en) * | 1990-04-07 | 1990-06-06 | Beecham Group Plc | Pharmaceutical formulation |
| GB0515492D0 (en) * | 2005-07-28 | 2005-08-31 | Reckitt Benckiser Healthcare | Improvements in or relating to compositions,articles and methods |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2984543A (en) * | 1957-03-19 | 1961-05-16 | Pierre F Smith | Stabilization of effervescent carbonate powders |
| US3401216A (en) * | 1964-01-09 | 1968-09-10 | Bristol Myers Co | Methods for preparing pharmaceutical compositions |
-
1969
- 1969-05-02 AT AT426369A patent/AT307616B/en not_active IP Right Cessation
-
1970
- 1970-04-13 GB GB07419/70A patent/GB1300998A/en not_active Expired
- 1970-04-24 NL NL7006040A patent/NL7006040A/xx unknown
- 1970-04-29 DE DE19702020893 patent/DE2020893A1/en active Pending
- 1970-04-30 FR FR7015900A patent/FR2043500B1/fr not_active Expired
- 1970-04-30 BE BE749864D patent/BE749864A/en unknown
- 1970-04-30 IL IL34417A patent/IL34417A/en unknown
- 1970-05-01 ZA ZA702964A patent/ZA702964B/en unknown
- 1970-05-01 AU AU14564/70A patent/AU1456470A/en not_active Expired
- 1970-05-01 JP JP45036883A patent/JPS4838844B1/ja active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2532849A1 (en) * | 1982-09-10 | 1984-03-16 | Glaxo Group Ltd | SOLID PHARMACEUTICAL COMPOSITION CONTAINING B-LACTAMIC ANTIBIOTICS, PROCESS FOR PREPARING THE SAME AND METHOD FOR STABILIZING A PHARMACEUTICAL COMPOSITION |
| GB2126479A (en) * | 1982-09-10 | 1984-03-28 | Glaxo Group Ltd | Pharmaceutical-compositions in inert carbon dioxide atmosphere |
| US5223246A (en) * | 1990-02-14 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
| US6051254A (en) * | 1990-04-07 | 2000-04-18 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US6077536A (en) * | 1990-04-07 | 2000-06-20 | Beecham Group Plc | Pharmaceutical formulation |
| WO1991016893A1 (en) | 1990-04-27 | 1991-11-14 | Beecham Group Plc | Pharmaceutical formulation |
| AU657476B2 (en) * | 1990-04-27 | 1995-03-16 | Beecham Group Plc | Effervescent amoxycillin formulation |
| US5670170A (en) * | 1990-04-27 | 1997-09-23 | Beecham Group P.L.C. | Pharamaceutical formulation |
| US5814337A (en) * | 1992-10-07 | 1998-09-29 | Beecham Group Plc | Pharmaceutical formulation |
| US6488961B1 (en) | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
| WO2014174405A1 (en) * | 2013-04-22 | 2014-10-30 | Webb Johannes Arnoldus Vosloo | Pharmaceutical preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2043500A1 (en) | 1971-02-19 |
| AU1456470A (en) | 1971-11-04 |
| NL7006040A (en) | 1970-11-04 |
| IL34417A0 (en) | 1970-06-17 |
| ZA702964B (en) | 1971-12-29 |
| AT307616B (en) | 1973-05-25 |
| BE749864A (en) | 1970-10-30 |
| IL34417A (en) | 1974-01-14 |
| FR2043500B1 (en) | 1974-03-22 |
| JPS4838844B1 (en) | 1973-11-20 |
| DE2020893A1 (en) | 1970-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |