GB1276839A - Antibiotic compositions - Google Patents
Antibiotic compositionsInfo
- Publication number
- GB1276839A GB1276839A GB3712368A GB3712368A GB1276839A GB 1276839 A GB1276839 A GB 1276839A GB 3712368 A GB3712368 A GB 3712368A GB 3712368 A GB3712368 A GB 3712368A GB 1276839 A GB1276839 A GB 1276839A
- Authority
- GB
- United Kingdom
- Prior art keywords
- effervescent
- antibiotic
- compositions
- acid
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 230000003115 biocidal effect Effects 0.000 title abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Substances OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 2
- 238000004090 dissolution Methods 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- XIYOPDCBBDCGOE-IWVLMIASSA-N (4s,4ar,5s,5ar,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methylidene-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C=C1C2=CC=CC(O)=C2C(O)=C2[C@@H]1[C@H](O)[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O XIYOPDCBBDCGOE-IWVLMIASSA-N 0.000 abstract 1
- ACTOXUHEUCPTEW-BWHGAVFKSA-N 2-[(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2s,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-o Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)[C@@H]1CC[C@H](N(C)C)[C@@H](C)O1 ACTOXUHEUCPTEW-BWHGAVFKSA-N 0.000 abstract 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 abstract 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 108010078777 Colistin Proteins 0.000 abstract 1
- DYDCUQKUCUHJBH-UWTATZPHSA-N D-Cycloserine Chemical compound N[C@@H]1CONC1=O DYDCUQKUCUHJBH-UWTATZPHSA-N 0.000 abstract 1
- DYDCUQKUCUHJBH-UHFFFAOYSA-N D-Cycloserine Natural products NC1CONC1=O DYDCUQKUCUHJBH-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- IECPWNUMDGFDKC-UHFFFAOYSA-N Fusicsaeure Natural products C12C(O)CC3C(=C(CCC=C(C)C)C(O)=O)C(OC(C)=O)CC3(C)C1(C)CCC1C2(C)CCC(O)C1C IECPWNUMDGFDKC-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 abstract 1
- 229930193140 Neomycin Natural products 0.000 abstract 1
- YJQPYGGHQPGBLI-UHFFFAOYSA-N Novobiocin Natural products O1C(C)(C)C(OC)C(OC(N)=O)C(O)C1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-UHFFFAOYSA-N 0.000 abstract 1
- 239000004100 Oxytetracycline Substances 0.000 abstract 1
- UOZODPSAJZTQNH-UHFFFAOYSA-N Paromomycin II Natural products NC1C(O)C(O)C(CN)OC1OC1C(O)C(OC2C(C(N)CC(N)C2O)OC2C(C(O)C(O)C(CO)O2)N)OC1CO UOZODPSAJZTQNH-UHFFFAOYSA-N 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- 229930195708 Penicillin V Natural products 0.000 abstract 1
- 239000004187 Spiramycin Substances 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- OZKXLOZHHUHGNV-UHFFFAOYSA-N Viomycin Natural products NCCCC(N)CC(=O)NC1CNC(=O)C(=CNC(=O)N)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC1=O)C2CC(O)NC(=N)N2 OZKXLOZHHUHGNV-UHFFFAOYSA-N 0.000 abstract 1
- 108010015940 Viomycin Proteins 0.000 abstract 1
- 229960000723 ampicillin Drugs 0.000 abstract 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 1
- 229960005091 chloramphenicol Drugs 0.000 abstract 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 abstract 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 abstract 1
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 abstract 1
- 229960003326 cloxacillin Drugs 0.000 abstract 1
- LQOLIRLGBULYKD-JKIFEVAISA-N cloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl LQOLIRLGBULYKD-JKIFEVAISA-N 0.000 abstract 1
- 229960003346 colistin Drugs 0.000 abstract 1
- 229960003077 cycloserine Drugs 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- VZPPEUOYDWPUKO-MQWDNKACSA-N fenbenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)C(C=1C=CC=CC=1)OC1=CC=CC=C1 VZPPEUOYDWPUKO-MQWDNKACSA-N 0.000 abstract 1
- 229950002965 fenbenicillin Drugs 0.000 abstract 1
- 229960004675 fusidic acid Drugs 0.000 abstract 1
- IECPWNUMDGFDKC-MZJAQBGESA-N fusidic acid Chemical compound O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 abstract 1
- 229960002442 glucosamine Drugs 0.000 abstract 1
- 239000002085 irritant Substances 0.000 abstract 1
- 231100000021 irritant Toxicity 0.000 abstract 1
- 229960005287 lincomycin Drugs 0.000 abstract 1
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 abstract 1
- 229940042016 methacycline Drugs 0.000 abstract 1
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 abstract 1
- 229960000515 nafcillin Drugs 0.000 abstract 1
- GPXLMGHLHQJAGZ-JTDSTZFVSA-N nafcillin Chemical compound C1=CC=CC2=C(C(=O)N[C@@H]3C(N4[C@H](C(C)(C)S[C@@H]43)C(O)=O)=O)C(OCC)=CC=C21 GPXLMGHLHQJAGZ-JTDSTZFVSA-N 0.000 abstract 1
- 229960004927 neomycin Drugs 0.000 abstract 1
- 229960002950 novobiocin Drugs 0.000 abstract 1
- YJQPYGGHQPGBLI-KGSXXDOSSA-N novobiocin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 abstract 1
- 229960001019 oxacillin Drugs 0.000 abstract 1
- UWYHMGVUTGAWSP-JKIFEVAISA-N oxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 abstract 1
- 229960000625 oxytetracycline Drugs 0.000 abstract 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 abstract 1
- 235000019366 oxytetracycline Nutrition 0.000 abstract 1
- UOZODPSAJZTQNH-LSWIJEOBSA-N paromomycin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO UOZODPSAJZTQNH-LSWIJEOBSA-N 0.000 abstract 1
- 229960001914 paromomycin Drugs 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 229940056367 penicillin v Drugs 0.000 abstract 1
- NONJJLVGHLVQQM-JHXYUMNGSA-N phenethicillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(C)OC1=CC=CC=C1 NONJJLVGHLVQQM-JHXYUMNGSA-N 0.000 abstract 1
- 229960004894 pheneticillin Drugs 0.000 abstract 1
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 abstract 1
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 abstract 1
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 abstract 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
- 235000015497 potassium bicarbonate Nutrition 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 235000011181 potassium carbonates Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000015424 sodium Nutrition 0.000 abstract 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 229960001294 spiramycin Drugs 0.000 abstract 1
- 235000019372 spiramycin Nutrition 0.000 abstract 1
- 229930191512 spiramycin Natural products 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 229960005322 streptomycin Drugs 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 229950001272 viomycin Drugs 0.000 abstract 1
- GXFAIFRPOKBQRV-GHXCTMGLSA-N viomycin Chemical compound N1C(=O)\C(=C\NC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CCCN)CNC(=O)[C@@H]1[C@@H]1NC(=N)N[C@@H](O)C1 GXFAIFRPOKBQRV-GHXCTMGLSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1276839 Effervescent antibiotic compositions SANDOZ PRODUCTS Ltd 31 July 1969 [2 Aug 1968] 37123/68 Heading A5B Effervescent antibiotic compositions, in a form suitable for dissolution in water to produce an orally acceptable effervescent solution, comprise (i) an effervescent agent and (ii) an antibiotic which goes into solution when the effervescent composition is dissolved in water, which is acid-stable, and which is neither irritant to the stomach nor destroyed therein, from 1 to 60 parts by weight of (i) being present for each part by weight of (ii), the composition being in unit dosage form and containing from 1 to 4gms of effervescent agent when a surface active agent is present. The antibiotic may be a penicillin or a salt thereof, such as phenoxymethyl penicillin or its potassium salt, ampicillin, cloxacillin, oxacillin, phenethicillin, phenbenicillin, nafcillin, novobiocin, fusidic acid, chloramphenicol, colistin, lincomycin, spiramycin, neomycin, paromomycin, viomycin, streptomycin, methacycline, erythromycin, chlorotetracycline, oxytetracycline, tetracycline, lymecyline and cycloserine. The effervescent agent may comprise a pharmaceutically acceptable carbonate e.g. sodium or potassium carbonate or bicarbonate; and a substance which on dissolution in water forms an acid-reacting substance e.g. citric or tartaric acid. The compositions may also contain glucosamine. The compositions are preferably in the form of tablets or sachets.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3712368A GB1276839A (en) | 1968-08-02 | 1968-08-02 | Antibiotic compositions |
| AT426469A AT308284B (en) | 1968-08-02 | 1969-05-02 | Process for making an effervescent preparation |
| DK382969A DK127167B (en) | 1968-08-02 | 1969-07-15 | Process for the preparation of a pharmaceutical effervescent composition of penicillin compounds. |
| DE19691938709 DE1938709A1 (en) | 1968-08-02 | 1969-07-30 | New compositions containing antibiotics |
| ES370058A ES370058A1 (en) | 1968-08-02 | 1969-07-30 | PROCEDURE FOR THE PREPARATION OF EFFERVESCENT PHARMACEUTICAL COMPOSITIONS. |
| NL6911804A NL6911804A (en) | 1968-08-02 | 1969-08-01 | |
| FR6926510A FR2014956B1 (en) | 1968-08-02 | 1969-08-01 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3712368A GB1276839A (en) | 1968-08-02 | 1968-08-02 | Antibiotic compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1276839A true GB1276839A (en) | 1972-06-07 |
Family
ID=10393920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3712368A Expired GB1276839A (en) | 1968-08-02 | 1968-08-02 | Antibiotic compositions |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT308284B (en) |
| DE (1) | DE1938709A1 (en) |
| DK (1) | DK127167B (en) |
| ES (1) | ES370058A1 (en) |
| FR (1) | FR2014956B1 (en) |
| GB (1) | GB1276839A (en) |
| NL (1) | NL6911804A (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2532849A1 (en) * | 1982-09-10 | 1984-03-16 | Glaxo Group Ltd | SOLID PHARMACEUTICAL COMPOSITION CONTAINING B-LACTAMIC ANTIBIOTICS, PROCESS FOR PREPARING THE SAME AND METHOD FOR STABILIZING A PHARMACEUTICAL COMPOSITION |
| US5223246A (en) * | 1990-02-14 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
| US6051254A (en) * | 1990-04-07 | 2000-04-18 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US6488961B1 (en) | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
| EP1728511A1 (en) * | 2005-05-31 | 2006-12-06 | Faust Pharmaceuticals | New use of phenethicillin and salts thereof. |
| WO2007147133A1 (en) * | 2006-06-15 | 2007-12-21 | Serenex, Inc. | Stabilized tetracycline compositions |
| WO2007147125A3 (en) * | 2006-06-15 | 2008-02-28 | Serenex Inc | Tetracycline package formulations |
| WO2008085310A3 (en) * | 2006-12-19 | 2008-08-21 | Schering Plough Ltd | Effervescent formulations of florfenicol for addition in drinking water systems |
| RU2355418C2 (en) * | 2003-06-24 | 2009-05-20 | Новартис Аг | Pharmaceutical composition |
| CN102670646A (en) * | 2012-05-07 | 2012-09-19 | 河南省康星药业有限公司 | Cattle effervescent tablet taking lincomycin hydrochloride as main component and preparation process for effervescent tablet |
| WO2016097754A1 (en) * | 2014-12-18 | 2016-06-23 | Helperby Therapeutics Limited | Novel combination and use |
| CN109453192A (en) * | 2018-12-06 | 2019-03-12 | 沧州爱农生物科技有限公司 | A kind of compound hydrochloric acid terramycin alumen borneol effervescent tablet and preparation method thereof |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1291281A (en) * | 1969-03-20 | 1972-10-04 | Pfizer Ltd | Improvements in pharmaceutical compositions |
| DE4420735C2 (en) * | 1994-06-15 | 1996-09-05 | Allphamed Arzneimittel Gmbh | Process for the production of mechanically stable, high-speed effervescent tablets |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US131123A (en) * | 1872-09-03 | Improvement in combined dental pluggers and burring-tools |
-
1968
- 1968-08-02 GB GB3712368A patent/GB1276839A/en not_active Expired
-
1969
- 1969-05-02 AT AT426469A patent/AT308284B/en active
- 1969-07-15 DK DK382969A patent/DK127167B/en unknown
- 1969-07-30 DE DE19691938709 patent/DE1938709A1/en active Pending
- 1969-07-30 ES ES370058A patent/ES370058A1/en not_active Expired
- 1969-08-01 NL NL6911804A patent/NL6911804A/xx unknown
- 1969-08-01 FR FR6926510A patent/FR2014956B1/fr not_active Expired
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2532849A1 (en) * | 1982-09-10 | 1984-03-16 | Glaxo Group Ltd | SOLID PHARMACEUTICAL COMPOSITION CONTAINING B-LACTAMIC ANTIBIOTICS, PROCESS FOR PREPARING THE SAME AND METHOD FOR STABILIZING A PHARMACEUTICAL COMPOSITION |
| GB2126479A (en) * | 1982-09-10 | 1984-03-28 | Glaxo Group Ltd | Pharmaceutical-compositions in inert carbon dioxide atmosphere |
| US5223246A (en) * | 1990-02-14 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Effervescent composition, its production and use |
| US6051254A (en) * | 1990-04-07 | 2000-04-18 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US6077536A (en) * | 1990-04-07 | 2000-06-20 | Beecham Group Plc | Pharmaceutical formulation |
| US6488961B1 (en) | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
| RU2355418C2 (en) * | 2003-06-24 | 2009-05-20 | Новартис Аг | Pharmaceutical composition |
| EP1728511A1 (en) * | 2005-05-31 | 2006-12-06 | Faust Pharmaceuticals | New use of phenethicillin and salts thereof. |
| WO2007147125A3 (en) * | 2006-06-15 | 2008-02-28 | Serenex Inc | Tetracycline package formulations |
| WO2007147133A1 (en) * | 2006-06-15 | 2007-12-21 | Serenex, Inc. | Stabilized tetracycline compositions |
| WO2008085310A3 (en) * | 2006-12-19 | 2008-08-21 | Schering Plough Ltd | Effervescent formulations of florfenicol for addition in drinking water systems |
| CN102670646A (en) * | 2012-05-07 | 2012-09-19 | 河南省康星药业有限公司 | Cattle effervescent tablet taking lincomycin hydrochloride as main component and preparation process for effervescent tablet |
| CN102670646B (en) * | 2012-05-07 | 2014-01-22 | 河南省康星药业股份有限公司 | Cattle effervescent tablet taking lincomycin hydrochloride as main component and preparation process for effervescent tablet |
| WO2016097754A1 (en) * | 2014-12-18 | 2016-06-23 | Helperby Therapeutics Limited | Novel combination and use |
| JP2018503614A (en) * | 2014-12-18 | 2018-02-08 | ヘルパービー セラピューティクス リミテッドＨｅｌｐｅｒｂｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | New combinations and uses |
| US10335454B2 (en) | 2014-12-18 | 2019-07-02 | Helperby Therapeutics Limited | Combination and use |
| JP2020033385A (en) * | 2014-12-18 | 2020-03-05 | ヘルパービー セラピューティクス リミテッドＨｅｌｐｅｒｂｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | Therapeutic agents for microbial infections |
| CN109453192A (en) * | 2018-12-06 | 2019-03-12 | 沧州爱农生物科技有限公司 | A kind of compound hydrochloric acid terramycin alumen borneol effervescent tablet and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1938709A1 (en) | 1970-04-02 |
| FR2014956B1 (en) | 1973-01-12 |
| ES370058A1 (en) | 1971-12-01 |
| FR2014956A1 (en) | 1970-04-24 |
| NL6911804A (en) | 1970-02-04 |
| DK127167B (en) | 1973-10-01 |
| AT308284B (en) | 1973-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |