GB1368251A - Theophylinylmethylethanoic acid ester - Google Patents
Theophylinylmethylethanoic acid esterInfo
- Publication number
- GB1368251A GB1368251A GB3942671A GB3942671A GB1368251A GB 1368251 A GB1368251 A GB 1368251A GB 3942671 A GB3942671 A GB 3942671A GB 3942671 A GB3942671 A GB 3942671A GB 1368251 A GB1368251 A GB 1368251A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- acid ester
- theophyllinyl
- aug
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 title 1
- MVQVNTPHUGQQHK-UHFFFAOYSA-N 3-pyridinemethanol Chemical compound OCC1=CC=CN=C1 MVQVNTPHUGQQHK-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229960000278 theophylline Drugs 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1368251 Theophyllinyl-ethanoic acid ester SO CI BRE 23 Aug 1971 [25 Aug 1970] 39426/71 Heading C2C The novel compound I and its acid addition salts are prepared by reacting pyridine-3-methanol with a compound II or a functional derivative thereof and optionally forming a salt. Theophyllinyl-7-ethanoic acid is prepared by reacting theophylline with 2-chloro-propionio acid ethyl ester, followed by hydrolysis. Pharmaceutical compositions having cerebral vaso-dilator activity comprise a compound I together with a suitable excipient for oral administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7031092A FR2101120B1 (en) | 1970-08-25 | 1970-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1368251A true GB1368251A (en) | 1974-09-25 |
Family
ID=9060560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3942671A Expired GB1368251A (en) | 1970-08-25 | 1971-08-23 | Theophylinylmethylethanoic acid ester |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE779718Q (en) |
| CA (1) | CA961039A (en) |
| CH (1) | CH540272A (en) |
| DE (1) | DE2142418A1 (en) |
| FR (1) | FR2101120B1 (en) |
| GB (1) | GB1368251A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2202686A1 (en) * | 1972-10-13 | 1974-05-10 | Fabre Sa Pierre | Nicotinyl theophylline acetate hydrochloride - ingredient in medicaments for circulatory disorders and dyslipemia |
| IT1173549B (en) * | 1984-04-02 | 1987-06-24 | Corvi Camillo Spa | ESTER OF TEOFILLIN-7-ACETIC ACID WITH D, L-TRANS-SOBREROL HAVING MUCOSECRETOLYTIC-FLUIDIFYING AND ANTIBRONCOSPASTIC ACTIVITY, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS |
-
1970
- 1970-08-25 FR FR7031092A patent/FR2101120B1/fr not_active Expired
-
1971
- 1971-08-23 GB GB3942671A patent/GB1368251A/en not_active Expired
- 1971-08-24 CA CA121,259A patent/CA961039A/en not_active Expired
- 1971-08-24 DE DE19712142418 patent/DE2142418A1/en active Pending
-
1972
- 1972-02-18 CH CH233372A patent/CH540272A/en not_active IP Right Cessation
- 1972-02-23 BE BE779718A patent/BE779718Q/en active
Also Published As
| Publication number | Publication date |
|---|---|
| BE779718Q (en) | 1972-06-16 |
| CA961039A (en) | 1975-01-14 |
| DE2142418A1 (en) | 1972-03-30 |
| FR2101120A1 (en) | 1972-03-31 |
| CH540272A (en) | 1973-09-28 |
| FR2101120B1 (en) | 1974-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |