GB1356723A - Antibiotic sf-1293 substance and its production and uses - Google Patents
Antibiotic sf-1293 substance and its production and usesInfo
- Publication number
- GB1356723A GB1356723A GB3500272A GB3500272A GB1356723A GB 1356723 A GB1356723 A GB 1356723A GB 3500272 A GB3500272 A GB 3500272A GB 3500272 A GB3500272 A GB 3500272A GB 1356723 A GB1356723 A GB 1356723A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotic
- substance
- july
- aqueous
- evaporated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000126 substance Substances 0.000 title abstract 4
- GINJFDRNADDBIN-FXQIFTODSA-N bilanafos Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCP(C)(O)=O GINJFDRNADDBIN-FXQIFTODSA-N 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- 230000003115 biocidal effect Effects 0.000 abstract 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 206010017533 Fungal infection Diseases 0.000 abstract 2
- 208000031888 Mycoses Diseases 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 241000187391 Streptomyces hygroscopicus Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 239000012871 anti-fungal composition Substances 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 238000005341 cation exchange Methods 0.000 abstract 1
- 239000003729 cation exchange resin Substances 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000012266 salt solution Substances 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000012049 topical pharmaceutical composition Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
- A01N57/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pest Control & Pesticides (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Agronomy & Crop Science (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
1356723 Antibiotic substance SF-1293 MEIJI SEIKA KAISHA Ltd 26 July 1972 [28 July 1971] 35002/72 Headings C2A and C2P The novel antibiotic SF-1293 having the formula is prepared by aerobically cultivating Streptomyces hygroscopicus ATCC 21705 or an SF-1293 substance-producing mutant or variant thereof in an aqueous nutrient medium until the desired antibiotic has accumulated therein and then isolating it from the culture. The antibiotic is an amorphous white amphoteric powder melting at 159-161‹ C., having an optical rotation [α]<SP>25</SP> D = -34 degrees (C = 1, H 2 O), being soluble in water and methanol, sparingly soluble in ethanol, chloroform, benzene and ethyl ether, and having antifungal properties. Isolation is effected by adsorption of the antibiotic from the preferably filtered culture on a cation-exchange or anion-exchange resin and eluting therefrom with an alkali or acid respectively. It may be purified by chromatography with an aqueous salt solution on a silica, cellulose or alumina column, the eluate being evaporated to dryness, the residue extracted with methanol, and the resulting solution being evaporated or made aqueous and freeze dried to give the purified SF-1293 substance. The antibiotic may be formulated into topical pharmaceutical compositions with a suitable ointment or lotion base and used to treat fungal infections of the skin, and into horticultural antifungal compositions for preventing or curing fungal infections in plants.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP46056032A JPS51639B1 (en) | 1971-07-28 | 1971-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1356723A true GB1356723A (en) | 1974-06-12 |
Family
ID=13015719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3500272A Expired GB1356723A (en) | 1971-07-28 | 1972-07-26 | Antibiotic sf-1293 substance and its production and uses |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS51639B1 (en) |
| CA (1) | CA975315A (en) |
| DE (1) | DE2236599C3 (en) |
| ES (1) | ES405289A1 (en) |
| FR (1) | FR2147291B1 (en) |
| GB (1) | GB1356723A (en) |
| IT (1) | IT1043879B (en) |
| NL (1) | NL162962C (en) |
| PH (1) | PH11050A (en) |
| SE (1) | SE384528B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1577232A (en) * | 1976-05-14 | 1980-10-22 | Roche Products Ltd | Peptide derivatives of phosphonic and phosphinic acids |
| GB2007976B (en) * | 1977-11-08 | 1982-06-09 | Meiji Seika Kaisha | Herbicidal composition and herbicidal processes |
-
1971
- 1971-07-28 JP JP46056032A patent/JPS51639B1/ja active Pending
-
1972
- 1972-07-24 SE SE967172A patent/SE384528B/en unknown
- 1972-07-26 DE DE19722236599 patent/DE2236599C3/en not_active Expired
- 1972-07-26 NL NL7210308A patent/NL162962C/en not_active IP Right Cessation
- 1972-07-26 GB GB3500272A patent/GB1356723A/en not_active Expired
- 1972-07-27 CA CA148,104A patent/CA975315A/en not_active Expired
- 1972-07-27 IT IT961172A patent/IT1043879B/en active
- 1972-07-28 PH PH13760A patent/PH11050A/en unknown
- 1972-07-28 FR FR7227247A patent/FR2147291B1/fr not_active Expired
- 1972-07-28 ES ES405289A patent/ES405289A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IT1043879B (en) | 1980-02-29 |
| CA975315A (en) | 1975-09-30 |
| SE384528B (en) | 1976-05-10 |
| ES405289A1 (en) | 1975-07-01 |
| DE2236599A1 (en) | 1973-02-08 |
| NL162962C (en) | 1980-07-15 |
| FR2147291A1 (en) | 1973-03-09 |
| NL7210308A (en) | 1973-01-30 |
| DE2236599B2 (en) | 1974-08-29 |
| FR2147291B1 (en) | 1975-03-07 |
| JPS51639B1 (en) | 1976-01-09 |
| NL162962B (en) | 1980-02-15 |
| DE2236599C3 (en) | 1975-04-24 |
| PH11050A (en) | 1977-10-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE36434L (en) | Gentamicin antibiotics. | |
| US3804948A (en) | Antifungal substances from polyangium cellulosum var.fulvum | |
| ES334165A1 (en) | PROCEDURE FOR THE PRODUCTION OF THE NEW ANTIBIOTIC SL 2266. | |
| GB1356723A (en) | Antibiotic sf-1293 substance and its production and uses | |
| GB1038242A (en) | Bleomycin and processes for preparation thereof | |
| IL42685A (en) | Antibiotic a-2315 and process for preparation thereof | |
| JPS55162993A (en) | Preparation of culavulanic acid | |
| US4279997A (en) | Process for production of aminoglycoside antibiotics | |
| SE328254B (en) | ||
| Hoeksema et al. | The isolation and characterization of rubradirin B | |
| GB1097189A (en) | Antifungal antibiotics | |
| ES341402A1 (en) | Antibiotics of agricultural fungicides,polyoxins d,e,f,g and h | |
| GB1388878A (en) | Antibiotics process for their production and use in ruminant feed | |
| GB1226665A (en) | ||
| ES355613A1 (en) | A PROCEDURE FOR PREPARING THE NEW ANTIBIOTICS POLYOXINS JK AND L. | |
| GB1107112A (en) | Antibiotic josamycin and processes for the production thereof | |
| GB1021401A (en) | Novel antibiotics and processes for their manufacture | |
| GB1224379A (en) | New antibiotic nk-1003 and processes for the production of the same | |
| JPS6331476B2 (en) | ||
| GB1212741A (en) | A method for producing an antibiotic b-2847 | |
| GB935327A (en) | The antibiotic baí¬8509 and its components a, b and c and pharmaceutical compositions containing the same | |
| JPS54119468A (en) | Novel antibiotic, nanaomycin e and its preparation | |
| GB1220017A (en) | Antibiotic substances related to daunomycin | |
| GB1452457A (en) | Microbiological production of biologically active 8,8-bi-1h- naphthol-2,3-c-pyrans | |
| ES337456A1 (en) | Antibiotics 16,511 R.P. and 18,051 R.P. and their preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |