GB1226665A - - Google Patents
Info
- Publication number
- GB1226665A GB1226665A GB1226665DA GB1226665A GB 1226665 A GB1226665 A GB 1226665A GB 1226665D A GB1226665D A GB 1226665DA GB 1226665 A GB1226665 A GB 1226665A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotic
- benzene
- ethyl acetate
- methanol
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 5
- 230000003115 biocidal effect Effects 0.000 abstract 5
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 238000010828 elution Methods 0.000 abstract 2
- 239000000741 silica gel Substances 0.000 abstract 2
- 229910002027 silica gel Inorganic materials 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010041925 Staphylococcal infections Diseases 0.000 abstract 1
- 241000747254 Streptomyces rochei subsp. volubilis Species 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000645 desinfectant Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- YWAKXRMUMFPDSH-UHFFFAOYSA-N pentene Chemical compound CCCC=C YWAKXRMUMFPDSH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003208 petroleum Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,226,665. Antibiotic T-2636. TAKEDA YAKUHIN YOGYO K.K. 15 May, 1968 [18 May, 1967; 8 May, 1968], No. 23032/68. Heading C2A. [Also in Division A5] The antibiotic T-2636 and its components A, B, C and D, a pentaene having antibacterial activity, is produced by cultivating Streptomyces rochei var. volubilis, especially strain IFO-12507, in a culture medium containing assimilable sources of carbon and nitrogen under aerobic conditions. The antibiotics may be obtained from the clarified broth or mycelium. The whole broth is adjusted to pH 3 to 8, preferably 5 to 6, filtered with a filter aid, and extracted at pH 2 to 9 and preferably 7.0 with a water-immiscible solvent such as ethyl acetate. The extract is treated with aqueous acid of pH 2 to 5, aqueous alkali of pH 8 to 10 and water and the crude antibiotic is precipitated by the addition of petroleum ether or hexane. The separated mycelium may be extracted with 70% aqueous acetone or 70% aqueous methanol, the extract treated with a solvent such as benzene and the crude antibiotic recovered therefrom. Purification is by chromatography on silica gel, elution with benzene or diethyl ether to remove impurities and then elution with chloroform/ methanol (95: 5). Separation into components is obtained by chromatography on silica gel followed by development using various solvent systems, e.g. benzene/ethyl acetate (8: 2), (7:3), (6:4), (5:5), (4:6), (3:7), (2:8) and ethyl acetate respectively. The antibiotic T-2636 components or mixtures thereof may be incorporated in ointments for the treatment of staphylococcal infections of humans and animals or may be dissolved in methanol or ethanol as a general disinfectant.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3161367 | 1967-05-18 | ||
| JP3108068 | 1968-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1226665A true GB1226665A (en) | 1971-03-31 |
Family
ID=26369531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1226665D Expired GB1226665A (en) | 1967-05-18 | 1968-05-15 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3626055A (en) |
| BE (1) | BE715356A (en) |
| CH (1) | CH513238A (en) |
| DE (1) | DE1770441C2 (en) |
| DK (1) | DK117626C (en) |
| FR (2) | FR1590599A (en) |
| GB (1) | GB1226665A (en) |
| NL (1) | NL142723B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4810442B1 (en) * | 1968-10-26 | 1973-04-03 | ||
| US4425356A (en) | 1980-11-29 | 1984-01-10 | Takeda Chemical Industries, Ltd. | Lankacidin derivatives used in swine husbandry |
| JPS58179496A (en) * | 1982-04-12 | 1983-10-20 | Takeda Chem Ind Ltd | Improved process for preparation of lankacidin |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2805185A (en) * | 1955-05-04 | 1957-09-03 | Du Pont | Antibiotic and production thereof |
| US3344024A (en) * | 1963-04-17 | 1967-09-26 | American Cyanamid Co | Antibiotic am-684 and method of production |
-
1968
- 1968-05-15 DK DK225768AA patent/DK117626C/en not_active IP Right Cessation
- 1968-05-15 GB GB1226665D patent/GB1226665A/en not_active Expired
- 1968-05-17 US US730113A patent/US3626055A/en not_active Expired - Lifetime
- 1968-05-17 FR FR1590599D patent/FR1590599A/fr not_active Expired
- 1968-05-17 DE DE1770441A patent/DE1770441C2/en not_active Expired
- 1968-05-17 BE BE715356D patent/BE715356A/xx not_active IP Right Cessation
- 1968-05-20 CH CH746568A patent/CH513238A/en not_active IP Right Cessation
- 1968-05-20 NL NL686807119A patent/NL142723B/en not_active IP Right Cessation
- 1968-08-14 FR FR162978A patent/FR8303M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1590599A (en) | 1970-04-20 |
| BE715356A (en) | 1968-10-16 |
| DK117626B (en) | 1970-05-19 |
| US3626055A (en) | 1971-12-07 |
| NL6807119A (en) | 1968-11-19 |
| DE1770441A1 (en) | 1971-10-21 |
| DK117626C (en) | 1970-10-19 |
| NL142723B (en) | 1974-07-15 |
| DE1770441C2 (en) | 1984-12-13 |
| CH513238A (en) | 1971-09-30 |
| FR8303M (en) | 1970-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |