GB1354871A - Polypeptides - Google Patents
PolypeptidesInfo
- Publication number
- GB1354871A GB1354871A GB3961570A GB3961570A GB1354871A GB 1354871 A GB1354871 A GB 1354871A GB 3961570 A GB3961570 A GB 3961570A GB 3961570 A GB3961570 A GB 3961570A GB 1354871 A GB1354871 A GB 1354871A
- Authority
- GB
- United Kingdom
- Prior art keywords
- activity
- morphine
- aug
- peptide
- blocking
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 3
- 229940024606 amino acid Drugs 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 2
- YWSYZEMJPFOFKY-UHFFFAOYSA-N 2,5-diamino-4-methyl-5-oxopentanoic acid Chemical compound NC(=O)C(C)CC(N)C(O)=O YWSYZEMJPFOFKY-UHFFFAOYSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 abstract 1
- 208000003098 Ganglion Cysts Diseases 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 208000005400 Synovial Cyst Diseases 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 229960003067 cystine Drugs 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 235000004554 glutamine Nutrition 0.000 abstract 1
- 235000018977 lysine Nutrition 0.000 abstract 1
- 229960005181 morphine Drugs 0.000 abstract 1
- 230000002232 neuromuscular Effects 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1354871 Peptides NELSON RESEARCH & DEVELOPMENT CO 16 Aug 1971 [17 Aug 1970 15 Sept 1970 15 Dec 1970] 39615/70 44072/70 and 59516/70 Heading C2C A peptide having 5 or more aminoacids and wherein the first, third, optionally the fifth, the seventh and optionally subsequent alternate amino acids of the polypeptides having a formula QNH.C(NH)NH 2 , QCONH 2 , QNH 2 or QCOOH where Q is HOOC.CH(NH 2 )-(CH 2 ) m and m is an integer greater than 0 (e.g. arginine glutamic acid, lysine, asparagine, glutamine, aspartic acid and α-amino-γ-carbamyl valeric acid), the other positions being occupied by other naturally occurring amino acids and where one of this is cystine the peptide may have a ladder-like structure of cross-linked chains. Pharmaceutical compositions useful to induce atropine-like and morphine-like activity, blocking neuro-muscular and ganglion activity and blocking the activity of prostaglandins, serotonine, morphine and glutamate in human or animal, are in forms suitable for oral, parenteral and topical administration.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3961570A GB1354871A (en) | 1970-08-17 | 1970-08-17 | Polypeptides |
| DE19712141024 DE2141024A1 (en) | 1970-08-17 | 1971-08-16 | Polypeptides |
| CA120,608A CA946376A (en) | 1970-08-17 | 1971-08-16 | Polypeptides |
| FR7129866A FR2102302A1 (en) | 1970-08-17 | 1971-08-16 | Peptides which interact with receptor sites - to give therapeutic effects |
| AU32408/71A AU460940B2 (en) | 1970-08-17 | 1971-08-16 | Polypeptides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3961570A GB1354871A (en) | 1970-08-17 | 1970-08-17 | Polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1354871A true GB1354871A (en) | 1974-05-30 |
Family
ID=10410532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3961570A Expired GB1354871A (en) | 1970-08-17 | 1970-08-17 | Polypeptides |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1354871A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114081934A (en) * | 2022-01-20 | 2022-02-25 | 江西省中医药研究院 | Traditional Chinese medicine composition and quality detection method thereof |
-
1970
- 1970-08-17 GB GB3961570A patent/GB1354871A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114081934A (en) * | 2022-01-20 | 2022-02-25 | 江西省中医药研究院 | Traditional Chinese medicine composition and quality detection method thereof |
| CN114081934B (en) * | 2022-01-20 | 2022-04-12 | 江西省中医药研究院 | Traditional Chinese medicine composition and quality detection method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |