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GB1345327A - Hydroxocobalamin derivatives - Google Patents

Hydroxocobalamin derivatives

Info

Publication number
GB1345327A
GB1345327A GB5124270A GB1345327DA GB1345327A GB 1345327 A GB1345327 A GB 1345327A GB 5124270 A GB5124270 A GB 5124270A GB 1345327D A GB1345327D A GB 1345327DA GB 1345327 A GB1345327 A GB 1345327A
Authority
GB
United Kingdom
Prior art keywords
hydroxocobalamin
amino acid
derivative
derivatives
oct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5124270A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB1345327A publication Critical patent/GB1345327A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B43/00—Preparation of azo dyes from other azo compounds
    • C09B43/32—Preparation of azo dyes from other azo compounds by reacting carboxylic or sulfonic groups, or derivatives thereof, with amines; by reacting keto-groups with amines
    • C09B43/38—Preparation of azo dyes from other azo compounds by reacting carboxylic or sulfonic groups, or derivatives thereof, with amines; by reacting keto-groups with amines by reacting two or more ortho-hydroxy naphthoic acid dyes with polyamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1345327 Hydroxocobalamin derivatives J BOIGE 28 Oct 1971 [28 Oct 1970 13 May 1971] 51242/70 and 14784/71 Heading C2V A derivative of hydroxocobalamin comprises a complex in which the hydroxyl group of the hydroxocobalamin is blocked by the amino group of an amino acid of formula where n is 1 or 2 and when n is 1 then R is hydrogen, methyl, and when n is 2 then R is hydrogen. The derivative is prepared by reacting the hydroxocobalamin with the amino acid in aqueous solution at ambient temperature, the pH being maintained at between 6À2 and 8À6. When the reaction is complete, crystallization is induced by adding a water-miscible organic liquid which does not dissolve hydroxocobalamin, e.g. acetone. The amino acid may be glycine, alphaalanine, beta-alanine, aspartic acid or glutamic acid. Examples are given. A pharmaceutical composition comprises the above-described derivative together with suitable diluents or carriers.
GB5124270A 1970-10-28 1971-10-28 Hydroxocobalamin derivatives Expired GB1345327A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5124270 1970-10-28
GB1478471 1971-05-13

Publications (1)

Publication Number Publication Date
GB1345327A true GB1345327A (en) 1974-01-30

Family

ID=26250793

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5124270A Expired GB1345327A (en) 1970-10-28 1971-10-28 Hydroxocobalamin derivatives

Country Status (8)

Country Link
BE (1) BE774108A (en)
CH (1) CH535248A (en)
ES (1) ES396350A1 (en)
FR (1) FR2111895B1 (en)
GB (1) GB1345327A (en)
IE (1) IE35780B1 (en)
LU (1) LU64101A1 (en)
NL (1) NL7114810A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428023A (en) * 1985-10-10 1995-06-27 Biotechnology Australia Pty. Ltd. Oral delivery of biologically active substances bound to vitamin B12 or analogues thereof
WO1998011900A3 (en) * 1996-09-18 1998-04-30 William J Sarill Compositions containing cobalamin and amino acids
US6159502A (en) * 1991-04-02 2000-12-12 Biotech Australia Pty Ltd Oral delivery systems for microparticles

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807832A (en) * 1987-06-09 1998-09-15 Biotech Australia Pty Limited Oral delivery of biologically active substances bound to vitamin B12

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428023A (en) * 1985-10-10 1995-06-27 Biotechnology Australia Pty. Ltd. Oral delivery of biologically active substances bound to vitamin B12 or analogues thereof
US5589463A (en) * 1985-10-10 1996-12-31 Biotechnology Autralia Pty., Ltd. Oral delivery of biologically active substances bound to vitamin B12
US6159502A (en) * 1991-04-02 2000-12-12 Biotech Australia Pty Ltd Oral delivery systems for microparticles
WO1998011900A3 (en) * 1996-09-18 1998-04-30 William J Sarill Compositions containing cobalamin and amino acids

Also Published As

Publication number Publication date
BE774108A (en) 1972-04-18
ES396350A1 (en) 1974-05-01
CH535248A (en) 1973-03-31
IE35780B1 (en) 1976-05-26
FR2111895A1 (en) 1972-06-09
FR2111895B1 (en) 1975-10-10
NL7114810A (en) 1972-05-03
LU64101A1 (en) 1973-05-03
IE35780L (en) 1972-04-28

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees