GB1216945A - Novel imidazoline derivatives, the preparation thereof and compositions containing the same - Google Patents
Novel imidazoline derivatives, the preparation thereof and compositions containing the sameInfo
- Publication number
- GB1216945A GB1216945A GB31544/69A GB3154469A GB1216945A GB 1216945 A GB1216945 A GB 1216945A GB 31544/69 A GB31544/69 A GB 31544/69A GB 3154469 A GB3154469 A GB 3154469A GB 1216945 A GB1216945 A GB 1216945A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenylamino
- preparation
- same
- compositions containing
- imidazoline derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002462 imidazolines Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 title 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229910052801 chlorine Chemical group 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- JCOPITWIWLFFPC-UHFFFAOYSA-N n-phenyl-4,5-dihydro-1h-imidazol-2-amine Chemical class N1CCN=C1NC1=CC=CC=C1 JCOPITWIWLFFPC-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1,216,945. 2-Phenylamino-imidazolines-(2). BOEHRINGER INGELHEIM G.m.b.H. 23 June, 1969 [21 June, 1968], No. 31544/69. Heading C2C. [Also in Division A5] Novel 2 - phenylamino - imidazolines - (2) of the general formula wherein R is a fluorine or chlorine atom or a cyano, trifluoromethyl, C 1-4 alkyl or C 1-4 alkoxy group and X is a fluorine, chlorine or bromine atom, and physiologically acceptable acid addition salts thereof are prepared by bromination of a 2-phenylamino-imidazoline- (2) of the general formula optional conversion of the resulting hydrobromide salt to the corresponding free base and optional conversion of the said free base to a physiologically acceptable acid addition salt thereof other than the hydrobromide salt.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT598868A AT285599B (en) | 1968-06-21 | 1968-06-21 | Process for the preparation of new trisubstituted 2-arylaminoimidazolines and their salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1216945A true GB1216945A (en) | 1970-12-23 |
Family
ID=3581723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31544/69A Expired GB1216945A (en) | 1968-06-21 | 1969-06-23 | Novel imidazoline derivatives, the preparation thereof and compositions containing the same |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT285599B (en) |
| BE (1) | BE734954A (en) |
| CH (1) | CH511856A (en) |
| DE (1) | DE1929950A1 (en) |
| ES (1) | ES368497A1 (en) |
| FR (1) | FR2011408A1 (en) |
| GB (1) | GB1216945A (en) |
| IL (1) | IL32444A0 (en) |
| NL (1) | NL6909515A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0081924A1 (en) * | 1981-11-20 | 1983-06-22 | Alcon Laboratories, Inc. | Topical compostions for lowering intraocular pressure |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| EP0116768A1 (en) * | 1982-12-23 | 1984-08-29 | Smithkline Beckman Corporation | 2-(4-Tert.-butyl-2,6-dichlorophenylimino)imidazolidine |
| US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
| US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
| US4644007A (en) * | 1981-11-20 | 1987-02-17 | Alcon Laboratories, Inc. | 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods |
| RU2230061C2 (en) * | 1995-04-20 | 2004-06-10 | Берингер Ингельхайм КГ | DERIVATIVES OF PHENYLAMINOIMIDAZOLINE OR PHENYLIMINOIMIDAZOLIDINE ELICITIN G WITH PROPERTY OF AGONIST OF α1L-ADRENOCEPTORS AND PHARMACEUTICAL COMPOSI TION BASED ON THEREOF |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2806775A1 (en) * | 1978-02-17 | 1979-08-30 | Boehringer Sohn Ingelheim | NEW SUBSTITUTED 2-PHENYLIMINO IMIDAZOLIDINE THEIR ACID ADDITION SALTS, MEDICINAL PRODUCTS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF |
| DE2949287A1 (en) * | 1979-12-07 | 1981-06-11 | C.H. Boehringer Sohn, 6507 Ingelheim | NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF |
| EP0043659B1 (en) * | 1980-07-09 | 1985-02-06 | Beecham Group Plc | Clonidine derivatives useful in the treatment of diarrhoea |
| DE8708009U1 (en) * | 1987-06-05 | 1987-08-20 | LESCHA Maschinenfabrik GmbH, 8900 Augsburg | Device for feeding a mixer |
-
1968
- 1968-06-21 AT AT598868A patent/AT285599B/en not_active IP Right Cessation
-
1969
- 1969-06-12 DE DE19691929950 patent/DE1929950A1/en active Pending
- 1969-06-17 CH CH923769A patent/CH511856A/en not_active IP Right Cessation
- 1969-06-18 ES ES368497A patent/ES368497A1/en not_active Expired
- 1969-06-20 BE BE734954D patent/BE734954A/xx unknown
- 1969-06-20 IL IL32444A patent/IL32444A0/en unknown
- 1969-06-20 FR FR6920713A patent/FR2011408A1/fr not_active Withdrawn
- 1969-06-20 NL NL6909515A patent/NL6909515A/xx unknown
- 1969-06-23 GB GB31544/69A patent/GB1216945A/en not_active Expired
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0081924A1 (en) * | 1981-11-20 | 1983-06-22 | Alcon Laboratories, Inc. | Topical compostions for lowering intraocular pressure |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
| US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
| US4644007A (en) * | 1981-11-20 | 1987-02-17 | Alcon Laboratories, Inc. | 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods |
| EP0116768A1 (en) * | 1982-12-23 | 1984-08-29 | Smithkline Beckman Corporation | 2-(4-Tert.-butyl-2,6-dichlorophenylimino)imidazolidine |
| RU2230061C2 (en) * | 1995-04-20 | 2004-06-10 | Берингер Ингельхайм КГ | DERIVATIVES OF PHENYLAMINOIMIDAZOLINE OR PHENYLIMINOIMIDAZOLIDINE ELICITIN G WITH PROPERTY OF AGONIST OF α1L-ADRENOCEPTORS AND PHARMACEUTICAL COMPOSI TION BASED ON THEREOF |
| US6858594B2 (en) | 1995-04-20 | 2005-02-22 | Boehringer Ingelheim Pharma Gmbh & Co Kg. | Compounds and methods for treating urinary incontinence |
| US7019021B2 (en) | 1995-04-20 | 2006-03-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Compounds and methods for treating urinary incontinence |
Also Published As
| Publication number | Publication date |
|---|---|
| BE734954A (en) | 1969-12-22 |
| CH511856A (en) | 1971-08-31 |
| IL32444A0 (en) | 1969-08-27 |
| NL6909515A (en) | 1969-12-23 |
| ES368497A1 (en) | 1971-05-01 |
| FR2011408A1 (en) | 1970-02-27 |
| DE1929950A1 (en) | 1970-03-05 |
| AT285599B (en) | 1970-11-10 |
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