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GB1268772A - NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME - Google Patents

NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME

Info

Publication number
GB1268772A
GB1268772A GB1273168A GB1273168A GB1268772A GB 1268772 A GB1268772 A GB 1268772A GB 1273168 A GB1273168 A GB 1273168A GB 1273168 A GB1273168 A GB 1273168A GB 1268772 A GB1268772 A GB 1268772A
Authority
GB
United Kingdom
Prior art keywords
compositions
substituted
carboline
araliphatic
lotions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1273168A
Inventor
Joseph Elks
Gordon Ian Gregory
John Derek Cocker
Leslie Stephenson
William Kingston Warburton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB1273168A priority Critical patent/GB1268772A/en
Priority to AT253169A priority patent/AT304533B/en
Priority to DE19691913119 priority patent/DE1913119A1/en
Priority to CH1876271A priority patent/CH536847A/en
Priority to CH1876371A priority patent/CH536848A/en
Priority to AT736471A priority patent/AT310155B/en
Priority to BE729855D priority patent/BE729855A/xx
Priority to CH389969A priority patent/CH553200A/en
Priority to IE33869A priority patent/IE32705B1/en
Priority to NL6903973A priority patent/NL6903973A/xx
Priority to FR6907280A priority patent/FR2003999A1/fr
Priority to CH1271771A priority patent/CH561206A5/xx
Publication of GB1268772A publication Critical patent/GB1268772A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1,268,772. Antiviral compositions. GLAXO LABORATORIES Ltd. 14 March, 1969 [15 March, 1968(2)], Nos. 12730/68 and 12731/68. Heading A5B. [Also in Division C2] Pharmaceutical or veterinary compositions having antiviral activity comprise, as active ingredient, at least one 2-substituted α-carboline of the general formula wherein R is a hydrogen atom or a substituted or unsubstituted aliphatic. araliphatic, aromatic or acyl group, X is a halogen atom or the residue of a nucleophile and wherein the nucleus is optionally additionally substituted by hydroxy, aliphatic, araliphatic, aromatic, carboxy, carboxylic acid ester, acylamino, amino, alkylamino, acyloxy, ether, nitro or sulphonic acid groups or halogen atoms, or physiologically compatible salt thereof, together with one or more pharmaceutical or veterinary carrier or excipient and/or other medicinal agents, e.g. anti-inflammatory agents such as steroids (e.g. betamethasone-21-phosphate) or antibiotics, such as tetracycline. The compositions may be administered orally, topically, rectally, intravaginally or parenterally in the form of tablets, capsules, lozenges, chewing gum, medicated sweets, solutions, suspensions, syrups, elixirs, emulsions, granules for constitution before use, liquid sprays, powder insufflations, nasal drops or ointments, throat paints, gargles, ophthalmic preparations and collyria, skin paints, lotions, creams, dusting powders, medicated dressings, eye drops and lotions, aerosols, suppositories, pessaries or injectable preparations. The compositions may also be formulated with a solid carrier or excipient or a sterile, pyrogen-free liquid or an aqueous oily liquid containing one or more suspending, dispersing, stabilising, preserving, solubilising, emulsifying or buffering agents. The compound 2-chloro-9-(3'-dimethylaminopiopyl) - α - carboline additionally shows neuroleptic activity.
GB1273168A 1968-03-15 1968-03-15 NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME Expired GB1268772A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB1273168A GB1268772A (en) 1968-03-15 1968-03-15 NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME
AT253169A AT304533B (en) 1968-03-15 1969-03-14 Process for the production of new α-carbolines and their salts
DE19691913119 DE1913119A1 (en) 1968-03-15 1969-03-14 Alpha carbolines and their method of manufacture
CH1876271A CH536847A (en) 1968-03-15 1969-03-14 2 substituted x-carbolines with antiviral activity and
CH1876371A CH536848A (en) 1968-03-15 1969-03-14 Process for the preparation of virostatically effective new α-carbolines
AT736471A AT310155B (en) 1968-03-15 1969-03-14 Process for the production of new α-carbolines and their salts
BE729855D BE729855A (en) 1968-03-15 1969-03-14
CH389969A CH553200A (en) 1968-03-15 1969-03-14 PROCESS FOR PRODUCING VIROSTATICALLY EFFECTIVE NEW (ALPHA) CARBOLINES.
IE33869A IE32705B1 (en) 1968-03-15 1969-03-14 Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same
NL6903973A NL6903973A (en) 1968-03-15 1969-03-14
FR6907280A FR2003999A1 (en) 1968-03-15 1969-03-14
CH1271771A CH561206A5 (en) 1968-03-15 1969-03-14

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1273068 1968-03-15
GB1273168A GB1268772A (en) 1968-03-15 1968-03-15 NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME

Publications (1)

Publication Number Publication Date
GB1268772A true GB1268772A (en) 1972-03-29

Family

ID=26249226

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1273168A Expired GB1268772A (en) 1968-03-15 1968-03-15 NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME

Country Status (8)

Country Link
AT (2) AT310155B (en)
BE (1) BE729855A (en)
CH (2) CH553200A (en)
DE (1) DE1913119A1 (en)
FR (1) FR2003999A1 (en)
GB (1) GB1268772A (en)
IE (1) IE32705B1 (en)
NL (1) NL6903973A (en)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000286A (en) 1975-05-28 1976-12-28 Merck & Co., Inc. 3-Phenyl,3H 1,2,3 triazolo[4,5-b]pyridines
EP0099614A3 (en) * 1982-07-02 1985-05-29 A.H. Robins Company, Incorporated Nitro, amino and aroylamino-n-phenylpyridinamines and their use in a process for preparing pyrido(1,4)benzodiazapines
WO1993020078A1 (en) * 1992-04-03 1993-10-14 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
US5502187A (en) * 1992-04-03 1996-03-26 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
WO1997005137A1 (en) * 1995-07-31 1997-02-13 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
US5696148A (en) * 1994-03-14 1997-12-09 Novo Nordisk A/S Indole compounds and their use in treating diseases of the central nervous system
US5783575A (en) * 1994-03-14 1998-07-21 Novo Nordisk A/S Antagonists, their preparation and use
CN1067061C (en) * 1993-04-28 2001-06-13 泽尼卡有限公司 Herbicidal substituted 1-phenyl or 1-pyridinyl-benzotriazoles
USRE37525E1 (en) 1991-05-01 2002-01-22 Henry M. Jackson Foundation Method for treating infectious respiratory diseases
WO2001051479A3 (en) * 2000-01-07 2002-02-14 Warner Lambert Co Tricyclic compounds with antiviral activity
US7064139B2 (en) * 2001-10-29 2006-06-20 Uniroyal Chemical Company, Inc. Method for treating retroviral infections
CZ299465B6 (en) * 2001-04-27 2008-08-06 Sanofi-Aventis Combination containing pyridoindolone derivative and anticancer agent
EP2161271A1 (en) * 2008-09-08 2010-03-10 Università Degli Studi Di Milano - Bicocca Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl
US7812165B2 (en) 2004-04-21 2010-10-12 Sanofi-Aventis 6-substituted pyridoindolone derivatives, production and therapeutic use thereof
US7816368B2 (en) 2002-10-23 2010-10-19 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
US8012991B2 (en) 2002-10-23 2011-09-06 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics
US8063061B2 (en) 2005-10-20 2011-11-22 Sanofi-Aventis 6-heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof
WO2015110263A1 (en) * 2014-01-21 2015-07-30 Ac Immune Sa Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyolid-like proteins
US10501457B2 (en) 2013-03-14 2019-12-10 Osteoqc Inc. Compounds for bone growth
US10947236B2 (en) 2018-08-14 2021-03-16 Osteoqc Inc. Pyrrolo-dipyridine compounds
US11903949B2 (en) 2018-08-14 2024-02-20 Ossifi Therapeutics Llc Fluoro beta-carboline compounds

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7605398L (en) * 1975-05-28 1976-11-29 Merck & Co Inc 3H-1,2,3-TRIZOLE (4,5-B) PYRIDINES
JPS5536401A (en) * 1978-06-09 1980-03-14 Japan Tobacco Inc Amino-alpha-carboline compound and mutagenic agent containing the same
FR2428642A1 (en) * 1978-06-15 1980-01-11 Sumitomo Chemical Co INDOLO-ISOQUINOLEIN DERIVATIVES
FR3109534B1 (en) 2020-04-22 2022-03-25 Soprema Installation and process for processing composite products based on thermoplastic materials

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000286A (en) 1975-05-28 1976-12-28 Merck & Co., Inc. 3-Phenyl,3H 1,2,3 triazolo[4,5-b]pyridines
EP0099614A3 (en) * 1982-07-02 1985-05-29 A.H. Robins Company, Incorporated Nitro, amino and aroylamino-n-phenylpyridinamines and their use in a process for preparing pyrido(1,4)benzodiazapines
USRE37525E1 (en) 1991-05-01 2002-01-22 Henry M. Jackson Foundation Method for treating infectious respiratory diseases
USRE38071E1 (en) 1991-05-01 2003-04-08 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Method for treating infectious respiratory diseases
AU675932B2 (en) * 1992-04-03 1997-02-27 Pharmacia & Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
US5502187A (en) * 1992-04-03 1996-03-26 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
WO1993020078A1 (en) * 1992-04-03 1993-10-14 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
CN1067061C (en) * 1993-04-28 2001-06-13 泽尼卡有限公司 Herbicidal substituted 1-phenyl or 1-pyridinyl-benzotriazoles
US5696148A (en) * 1994-03-14 1997-12-09 Novo Nordisk A/S Indole compounds and their use in treating diseases of the central nervous system
US5783575A (en) * 1994-03-14 1998-07-21 Novo Nordisk A/S Antagonists, their preparation and use
US5945417A (en) * 1995-07-31 1999-08-31 Novo Nordisk Heterocyclic compounds, their preparation and use
WO1997005137A1 (en) * 1995-07-31 1997-02-13 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
WO2001051479A3 (en) * 2000-01-07 2002-02-14 Warner Lambert Co Tricyclic compounds with antiviral activity
US6800656B2 (en) 2000-01-07 2004-10-05 Warner Lambert Company Tricyclic compounds and method of treating herpes virus
CZ299465B6 (en) * 2001-04-27 2008-08-06 Sanofi-Aventis Combination containing pyridoindolone derivative and anticancer agent
US7064139B2 (en) * 2001-10-29 2006-06-20 Uniroyal Chemical Company, Inc. Method for treating retroviral infections
US7816368B2 (en) 2002-10-23 2010-10-19 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
US8012991B2 (en) 2002-10-23 2011-09-06 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics
US7812165B2 (en) 2004-04-21 2010-10-12 Sanofi-Aventis 6-substituted pyridoindolone derivatives, production and therapeutic use thereof
US8063061B2 (en) 2005-10-20 2011-11-22 Sanofi-Aventis 6-heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof
EP2161271A1 (en) * 2008-09-08 2010-03-10 Università Degli Studi Di Milano - Bicocca Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl
JP2012501984A (en) * 2008-09-08 2012-01-26 ウニヴェルシダ’デリ ストゥディ ディ ミラノ−ビコッカ Α-carboline inhibitors of NPM-ALK, RET and BCR-ABL
US8895744B2 (en) 2008-09-08 2014-11-25 Universita' Degli Studi Di Milano-Bicocca Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl
US10501457B2 (en) 2013-03-14 2019-12-10 Osteoqc Inc. Compounds for bone growth
US11267814B2 (en) 2013-03-14 2022-03-08 OsteoQC, Inc. Compounds for bone growth
WO2015110263A1 (en) * 2014-01-21 2015-07-30 Ac Immune Sa Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyolid-like proteins
US10662193B2 (en) 2014-01-21 2020-05-26 Ac Immune Sa Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins
US10947236B2 (en) 2018-08-14 2021-03-16 Osteoqc Inc. Pyrrolo-dipyridine compounds
US11655250B2 (en) 2018-08-14 2023-05-23 Osteoqc Inc. Pyrrolo-dipyridine compounds
US11903949B2 (en) 2018-08-14 2024-02-20 Ossifi Therapeutics Llc Fluoro beta-carboline compounds
US12195461B2 (en) 2018-08-14 2025-01-14 Ossifi Therapeutics Llc Pyrrolo-dipyridine compounds
US12324809B2 (en) 2018-08-14 2025-06-10 Ossifi Therapeutics Llc Fluoro beta-carboline compounds

Also Published As

Publication number Publication date
AT304533B (en) 1973-01-10
IE32705L (en) 1969-09-15
IE32705B1 (en) 1973-10-31
NL6903973A (en) 1969-09-17
BE729855A (en) 1969-09-15
AT310155B (en) 1973-09-25
FR2003999A1 (en) 1969-11-14
DE1913119A1 (en) 1970-08-06
CH553200A (en) 1974-08-30
CH561206A5 (en) 1975-04-30

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